{"id":"https://openalex.org/W2394963940","doi":null,"title":"Tissue factor and the extrinsic pathway of coagulation during infection and vascular inflammation.","display_name":"Tissue factor and the extrinsic pathway of coagulation during infection and vascular inflammation.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2394963940","mag":"2394963940","pmid":"https://pubmed.ncbi.nlm.nih.gov/8131798"},"language":"en","primary_location":{"id":"pmid:8131798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8131798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011133615","display_name":"Steven D. Carson","orcid":"https://orcid.org/0000-0001-9586-1951","observed_orcids":["https://orcid.org/0000-0001-9586-1951"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S D Carson","raw_affiliation_strings":["University of Nebraska Medical Center, Department of Pathology and Microbiology, Omaha 68198-6495"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center, Department of Pathology and Microbiology, Omaha 68198-6495","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059501633","display_name":"Deborah R. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Johnson","raw_affiliation_strings":["Pathology & Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology & Microbiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107772571","display_name":"Steven Tracy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Tracy","raw_affiliation_strings":["Pathology & Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology & Microbiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9559,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.72052574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"14 Suppl K","issue":null,"first_page":"98","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":1.0},{"id":"https://openalex.org/keywords/extrinsic-coagulation-pathway","display_name":"extrinsic coagulation pathway","score":0.9679999947547913},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.6290000081062317},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8740000128746033},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/anticoagulant-mechanism","display_name":"anticoagulant mechanism","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.946538507938385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7198156118392944},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6990710496902466},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.6457552313804626},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6418900489807129},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.5716239213943481},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5520423650741577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5498181581497192},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4852740466594696},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.42725038528442383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35706382989883423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17272508144378662},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1705332100391388}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8131798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8131798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"},{"id":"mag:2394963940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8131798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7762241166","display_name":"CONTROL OF TISSUE FACTOR ACTIVITY","funder_award_id":"K04HL002072","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089545220","https://openalex.org/W2148648687","https://openalex.org/W2443307141","https://openalex.org/W1959238183","https://openalex.org/W2267226449","https://openalex.org/W2415553152","https://openalex.org/W2072617501","https://openalex.org/W2071212417","https://openalex.org/W1603217813","https://openalex.org/W2054730423"],"abstract_inverted_index":{"Tissue":[0],"factor":[1,60,84,104,134],"is":[2],"a":[3],"potent":[4],"initiator":[5],"of":[6,37,58,65,92,99,132],"blood":[7,35],"coagulation.":[8],"In":[9],"tissue":[10,59,83,103,133],"sections,":[11],"it":[12],"has":[13,29],"been":[14,30],"immunologically":[15],"demonstrated":[16,32],"in":[17,21,33,52,106],"cells":[18,49],"normally":[19],"not":[20],"contact":[22],"with":[23,47,111,126],"circulating":[24],"blood,":[25],"and":[26,50,101,108,146],"elevated":[27,128],"activity":[28,85,116,135],"repeatedly":[31],"peripheral":[34],"monocytes":[36,51],"patients":[38],"considered":[39],"to":[40,150],"be":[41,151],"at":[42,136],"risk":[43],"for":[44],"thrombosis.":[45],"Studies":[46],"endothelial":[48],"culture":[53],"have":[54],"documented":[55],"the":[56,66,82,89,93,112],"induction":[57],"synthesis":[61],"by":[62,75,142],"biochemical":[63],"mediators":[64],"inflammatory":[67,124],"process.":[68],"Lytic":[69],"processes,":[70],"such":[71],"as":[72],"those":[73],"caused":[74],"complement":[76],"activation":[77],"or":[78],"viral":[79],"infections,":[80],"increase":[81],"several":[86],"fold":[87],"over":[88],"basal":[90],"level":[91],"affected":[94],"cells.":[95],"Diminished":[96],"anti-thrombotic":[97],"properties":[98],"endothelium,":[100],"induced":[102],"expression":[105],"endothelium":[107],"monocytes/macrophages,":[109],"combined":[110],"increased":[113],"specific":[114],"procoagulant":[115,129,138],"resulting":[117],"from":[118],"cell":[119],"membrane":[120],"damage,":[121],"may":[122],"endow":[123],"foci":[125],"dramatically":[127],"activity.":[130],"Levels":[131],"which":[137],"mechanisms":[139,145],"escape":[140],"regulation":[141],"natural":[143],"anticoagulant":[144],"produce":[147],"thrombosis":[148],"remain":[149],"determined.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}