{"id":"https://openalex.org/W2394945112","doi":null,"title":"Cell-based quantitative evaluation of the MTT assay.","display_name":"Cell-based quantitative evaluation of the MTT assay.","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2394945112","mag":"2394945112","pmid":"https://pubmed.ncbi.nlm.nih.gov/14603722"},"language":"en","primary_location":{"id":"pmid:14603722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14603722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and quantitative cytology and histology","raw_type":"Evaluation Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110169472","display_name":"Beatriz L. Molinari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I9340077","display_name":"Comisi\u00f3n Nacional de Energ\u00eda At\u00f3mica","ror":"https://ror.org/01xz39a70","country_code":"AR","type":"government","lineage":["https://openalex.org/I9340077"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Beatriz L Molinari","raw_affiliation_strings":["National Research Council and Radiobiology Department, National Laboratories of Research and Service-Conicet, National Atomic Energy Commission, Avda. Gral. Paz 1499, (1650) San Mart\u00edn, Pcia Buenos Aires, Argentina. beamolin@cnea.gov.ar","National Research Council and Radiobiology Department, National Laboratories of Research and Service-Conicet, National Atomic Energy Commission, Avda. Gral. Paz 1499, (1650) San Mart\u00edn, Pcia Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council and Radiobiology Department, National Laboratories of Research and Service-Conicet, National Atomic Energy Commission, Avda. Gral. Paz 1499, (1650) San Mart\u00edn, Pcia Buenos Aires, Argentina. beamolin@cnea.gov.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I9340077"]},{"raw_affiliation_string":"National Research Council and Radiobiology Department, National Laboratories of Research and Service-Conicet, National Atomic Energy Commission, Avda. Gral. Paz 1499, (1650) San Mart\u00edn, Pcia Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I9340077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007096758","display_name":"Deborah R. Tasat","orcid":"https://orcid.org/0000-0002-8087-7579","observed_orcids":["https://orcid.org/0000-0002-8087-7579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D\u00e9bora R Tasat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027228051","display_name":"M\u00f3nica A. Palmieri","orcid":"https://orcid.org/0000-0002-3652-3589","observed_orcids":["https://orcid.org/0000-0002-3652-3589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00f3nica A Palmieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034523589","display_name":"Silvia O'Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia E O'Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015880259","display_name":"Romulo Luis Cabrini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R\u00f3mulo L Cabrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.875,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.74312956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"5","first_page":"254","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.3644999861717224,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtt-assay","display_name":"MTT assay","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-size","display_name":"cell size","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-size-heterogeneity","display_name":"cell size heterogeneity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/v79-cells","display_name":"V79 cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9340000152587891},{"id":"https://openalex.org/keywords/serum-levels","display_name":"serum concentration","score":0.4749999940395355},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.593999981880188},{"id":"https://openalex.org/keywords/cell-viability-assay","display_name":"cell viability assay","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2776892249","wikidata":"https://www.wikidata.org/wiki/Q2324668","display_name":"Formazan","level":2,"score":0.9592797160148621},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.8616547584533691},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6115217804908752},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5575698018074036},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.556048572063446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5019965171813965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4428642690181732},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3686618208885193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.299494206905365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29843348264694214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003239","descriptor_name":"Connective Tissue Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003239","descriptor_name":"Connective Tissue Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003239","descriptor_name":"Connective Tissue Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003581","descriptor_name":"Cytodiagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14603722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14603722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and quantitative cytology and histology","raw_type":"Evaluation Study"},{"id":"mag:2394945112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14603722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153380231","https://openalex.org/W2418775906","https://openalex.org/W1968823236","https://openalex.org/W1819048918","https://openalex.org/W7214725113","https://openalex.org/W3216591159","https://openalex.org/W4309026335","https://openalex.org/W2807183240","https://openalex.org/W2182126825","https://openalex.org/W2341769195"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"analyze":[2],"the":[3,75,89,95,137,144,148],"bioreduction":[4,116],"of":[5,21,24,42,55,61,91,98,107,114,139],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[6],"bromide":[7],"(MTT)":[8],"on":[9],"a":[10,19,112],"per":[11,101,109],"cell":[12,25,36,87,93,110,123],"basis":[13],"and":[14,38,45,133],"evaluate":[15],"its":[16],"modulation":[17],"as":[18,111],"function":[20],"different":[22,62],"stages":[23],"metabolism.":[26],"STUDY":[27],"DESIGN:":[28],"Following":[29],"MTT":[30,115,145],"bioreduction,":[31],"total":[32,96],"optical":[33],"density":[34],"(TOD),":[35],"area":[37],"specific":[39],"activity":[40,77,128],"(TOD/area)":[41],"V79":[43],"cells":[44,52,81],"cultured":[46],"macrophages":[47],"were":[48],"recorded":[49],"for":[50],"individual":[51],"by":[53],"means":[54],"digital":[56],"image":[57],"analysis.":[58],"The":[59,105],"effect":[60],"serum":[63],"(0-10%":[64],"vol/vol)":[65],"or":[66],"genistein":[67],"(0-100":[68],"microM)":[69],"concentrations":[70],"was":[71,117,129],"used":[72],"to":[73,94,119,122],"modulate":[74],"MTT-specific":[76],"response.":[78],"RESULTS:":[79],"As":[80],"in":[82,86,131,142],"culture":[83],"are":[84],"heterogeneous":[85],"size,":[88],"contribution":[90],"each":[92],"amount":[97],"formazan":[99,108],"formed":[100],"dish":[102],"is":[103],"variable.":[104],"production":[106],"result":[113],"found":[118],"be":[120],"proportional":[121],"size.":[124],"CONCLUSION:":[125],"Specific":[126],"MTT-reducing":[127],"analyzed":[130],"phagocytes":[132],"nonphagocyte":[134],"cells,":[135],"revealing":[136],"utility":[138],"this":[140],"variable":[141],"evaluating":[143],"assay":[146],"at":[147],"single-cell":[149],"level.":[150]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
