{"id":"https://openalex.org/W2394940540","doi":null,"title":"The ileum is the major site of absorption of vitamin B12 analogues.","display_name":"The ileum is the major site of absorption of vitamin B12 analogues.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2394940540","mag":"2394940540","pmid":"https://pubmed.ncbi.nlm.nih.gov/2912026"},"language":"en","primary_location":{"id":"pmid:2912026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2912026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111750231","display_name":"Sheryl Shaw","orcid":"https://orcid.org/0000-0003-0000-7993","observed_orcids":["https://orcid.org/0000-0003-0000-7993"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Shaw","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, New York","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089105819","display_name":"Elizabeth Jayatilleke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Jayatilleke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111151380","display_name":"S Meyers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Meyers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754661","display_name":"N Colman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Colman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071469921","display_name":"Barry C. Herzlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Herzlich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111477502","display_name":"Victor D. Herbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Herbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3745,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8043306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"84","issue":"1","first_page":"22","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12-analogues","display_name":"vitamin B12 analogues","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.6620000004768372},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pernicious-anemia","display_name":"pernicious anemia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ileal-resection","display_name":"ileal resection","score":0.9240000247955322},{"id":"https://openalex.org/keywords/crohn-s-colitis","display_name":"Crohn's colitis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9919999837875366},{"id":"https://openalex.org/keywords/colonic-bacteria","display_name":"colonic bacteria","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.8702539205551147},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7703929543495178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7598574757575989},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7080389261245728},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.6835587024688721},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6556428670883179},{"id":"https://openalex.org/C2780676250","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Cobalamin","level":3,"score":0.613344669342041},{"id":"https://openalex.org/C2777569460","wikidata":"https://www.wikidata.org/wiki/Q410153","display_name":"Intrinsic factor","level":3,"score":0.6024120450019836},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.5928431749343872},{"id":"https://openalex.org/C2775916456","wikidata":"https://www.wikidata.org/wiki/Q1346016","display_name":"pernicious anemia","level":3,"score":0.5618372559547424},{"id":"https://openalex.org/C2780439177","wikidata":"https://www.wikidata.org/wiki/Q1442923","display_name":"Malabsorption","level":2,"score":0.4409196376800537},{"id":"https://openalex.org/C2780941987","wikidata":"https://www.wikidata.org/wiki/Q3796380","display_name":"Ileitis","level":4,"score":0.4277505874633789},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.41547197103500366},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3426896929740906},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.320343554019928},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.27209728956222534},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000752","descriptor_name":"Anemia, Pernicious","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007079","descriptor_name":"Ileitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2912026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2912026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:2394940540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2912026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1683370326","https://openalex.org/W147517836","https://openalex.org/W2152346144","https://openalex.org/W2010673037","https://openalex.org/W7073900437","https://openalex.org/W2410148613","https://openalex.org/W2413220426","https://openalex.org/W1965988896","https://openalex.org/W2256741699","https://openalex.org/W2080409616"],"abstract_inverted_index":{"Non-cobalamin":[0],"vitamin":[1,42,141],"B12":[2,37,43,84,97,111,119,142],"analogues":[3,21,38,45,98,120],"constitute":[4],"a":[5,127],"significant":[6],"percentage":[7],"of":[8,18,20,32,36,83,130,140],"total":[9,94],"corrinoids":[10],"in":[11,46,99,123],"human":[12],"serum.":[13],"The":[14],"source":[15],"and":[16,22,34,44,63,93,112,133,137],"means":[17],"absorption":[19,35],"their":[23,148],"significance":[24],"are":[25,121],"largely":[26],"unknown.":[27],"We":[28],"studied":[29],"the":[30,100,124],"sites":[31],"production":[33],"by":[39,126],"measuring":[40],"serum":[41,118],"93":[47],"patients":[48],"with":[49,69,87,104],"various":[50],"gastrointestinal":[51],"diseases:":[52],"pernicious":[53],"anemia":[54],"(PA),":[55],"ileal":[56],"resections,":[57],"ileitis,":[58],"Crohn's":[59,89],"colitis,":[60,62,90,92],"ulcerative":[61,91],"irritable":[64],"bowel":[65],"syndrome":[66],"(IBS).":[67],"Patients":[68,86,103],"PA":[70],"had":[71,96,109],"normal":[72,101],"analogue":[73],"levels":[74],"that":[75,79,117,134],"were":[76],"unchanged":[77],"or":[78,106],"rose":[80],"during":[81],"cessation":[82],"administration.":[85],"IBS,":[88],"colectomies":[95],"range.":[102],"diseased":[105],"resected":[107],"ileums":[108],"low":[110],"analogues.":[113],"These":[114],"data":[115],"suggest":[116],"absorbed":[122],"ileum":[125],"mechanism":[128],"independent":[129],"intrinsic":[131],"factor,":[132],"colonic":[135],"bacteria":[136],"endogenous":[138],"metabolism":[139],"do":[143],"not":[144],"contribute":[145],"significantly":[146],"to":[147],"level.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}