{"id":"https://openalex.org/W2394915045","doi":null,"title":"Chromothripsis-like patterns are recurring, but heterogeneously distributed features in cancer: A survey of 22, 347 genomic copy number profiles.","display_name":"Chromothripsis-like patterns are recurring, but heterogeneously distributed features in cancer: A survey of 22, 347 genomic copy number profiles.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2394915045","mag":"2394915045"},"language":"en","primary_location":{"id":"mag:2394915045","doi":null,"is_oa":false,"landing_page_url":"http://iwbbio.ugr.es/papers/iwbbio_007.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306514693","display_name":"IWBBIO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"IWBBIO","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090189228","display_name":"Haoyang Cai","orcid":"https://orcid.org/0000-0001-8552-8565","observed_orcids":["https://orcid.org/0000-0001-8552-8565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haoyang Cai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8552-8565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009061545","display_name":"Nitin Kumar","orcid":"https://orcid.org/0000-0001-7466-3171","observed_orcids":["https://orcid.org/0000-0001-7466-3171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nitin Kumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7466-3171","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002035722","display_name":"Homayoun C. Bagheri","orcid":"https://orcid.org/0000-0002-2495-7785","observed_orcids":["https://orcid.org/0000-0002-2495-7785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Homayoun C. Bagheri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2495-7785","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000334281","display_name":"Christian von Mering","orcid":"https://orcid.org/0000-0001-7734-9102","observed_orcids":["https://orcid.org/0000-0001-7734-9102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian von Mering","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7734-9102","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029455059","display_name":"Mark D. Robinson","orcid":"https://orcid.org/0000-0002-3048-5518","observed_orcids":["https://orcid.org/0000-0002-3048-5518","https://orcid.org/0000-0001-5677-3078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark D. Robinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3048-5518","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023290722","display_name":"Michael Baudis","orcid":"https://orcid.org/0000-0002-9903-4248","observed_orcids":["https://orcid.org/0000-0002-9903-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Baudis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9903-4248","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24752061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"49","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1005999967455864,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromothripsis","display_name":"chromothripsis","score":0.925000011920929},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8379999995231628},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.8339999914169312},{"id":"https://openalex.org/keywords/breakage-fusion-bridge-cycles","display_name":"breakage-fusion-bridge cycles","score":0.8159999847412109},{"id":"https://openalex.org/keywords/soft-tissue-tumors","display_name":"soft tissue tumor","score":0.7860000133514404},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.9435437917709351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6338915824890137},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5865417718887329},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5644054412841797},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46553531289100647},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.46416619420051575},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44543200731277466},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4410814046859741},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.4336746037006378},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4253471791744232},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.41460925340652466},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.4103092551231384},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3768320679664612},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3216133415699005},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.31302157044410706},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21307820081710815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19992080330848694},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.12707579135894775},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.08135655522346497},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2394915045","doi":null,"is_oa":false,"landing_page_url":"http://iwbbio.ugr.es/papers/iwbbio_007.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306514693","display_name":"IWBBIO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"IWBBIO","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2139266962","https://openalex.org/W2109948920","https://openalex.org/W3022927847","https://openalex.org/W2790201836","https://openalex.org/W2885933450","https://openalex.org/W3005469082","https://openalex.org/W1505909540","https://openalex.org/W2885358263","https://openalex.org/W2311924792","https://openalex.org/W2045762186"],"abstract_inverted_index":{"Chromothripsis":[0],"is":[1],"a":[2,25,46,75,140],"newly":[3],"discovered":[4],"type":[5],"of":[6,42,77,143,157],"genomic":[7,43],"rearrangement,":[8],"characterized":[9],"by":[10],"locally":[11],"clustered":[12],"copy":[13,128],"number":[14,129],"aberrations.":[15],"It":[16,30],"has":[17],"been":[18],"proposed":[19],"that":[20,118,166],"it":[21],"may":[22,170],"arise":[23],"during":[24],"single":[26],"genome":[27,68],"shattering":[28],"event.":[29,49],"provides":[31],"an":[32],"alternative":[33],"paradigm":[34],"in":[35,71,123],"cancer":[36,85,104],"development,":[37],"replacing":[38],"the":[39,51,102,135,158],"gradual":[40],"accumulation":[41],"changes":[44],"with":[45,173],"one-off":[47],"catastrophic":[48,168],"However,":[50],"underlying":[52,160],"mechanisms":[53],"and":[54,99,146,177],"its":[55],"specific":[56],"impact":[57],"on":[58,94],"tumorigenesis":[59],"are":[60],"still":[61],"poorly":[62],"understood.":[63],"Here,":[64],"we":[65],"identified":[66],"chromothripsis-like":[67],"patterns":[69],"(CTLP)":[70],"918":[72],"cases,":[73],"from":[74],"dataset":[76],"more":[78],"than":[79],"22,000":[80],"oncogenomic":[81],"arrays":[82],"including":[83],"132":[84],"types.":[86],"Fragmentation":[87],"hotspots":[88],"were":[89],"found":[90],"to":[91],"be":[92,171],"located":[93],"chromosome":[95],"8,":[96],"11,":[97],"12":[98],"17.":[100],"Among":[101],"various":[103],"types,":[105],"soft":[106],"tissue":[107],"tumors":[108],"exhibited":[109],"particularly":[110],"high":[111],"CTLP":[112,119],"frequencies.":[113],"Genomic":[114],"context":[115],"analysis":[116],"revealed":[117],"rearrangements":[120],"frequently":[121],"occurred":[122],"genomes":[124],"harboring":[125],"multiple":[126],"additional":[127],"aberrations":[130],"(CNAs).":[131],"An":[132],"investigation":[133],"into":[134],"affected":[136],"chromosomal":[137],"regions":[138],"showed":[139],"large":[141],"proportion":[142],"arm-level":[144],"pulverization":[145],"telomere":[147],"related":[148],"events,":[149],"which":[150],"would":[151],"support":[152],"breakage-fusion-bridge":[153],"cycles":[154],"as":[155],"one":[156],"potential":[159],"mechanisms.":[161],"We":[162],"also":[163],"report":[164],"evidence":[165],"this":[167],"event":[169],"correlated":[172],"patient":[174],"age,":[175],"stage":[176],"survival":[178],"rate.":[179]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}