{"id":"https://openalex.org/W2394911027","doi":null,"title":"[A new type of ANCA in sera of patients with ulcerative colitis: effects of therapy and disease severity on serum titer].","display_name":"[A new type of ANCA in sera of patients with ulcerative colitis: effects of therapy and disease severity on serum titer].","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W2394911027","mag":"2394911027","pmid":"https://pubmed.ncbi.nlm.nih.gov/1563754"},"language":"de","primary_location":{"id":"pmid:1563754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1563754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunitat und Infektion","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062699406","display_name":"J\u00f6rg A. Rump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J A Rump","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik Freiburg, Abteilung Rheumatologie und Klinische Immunologie, Universit\u00e4t L\u00fcbeck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik Freiburg, Abteilung Rheumatologie und Klinische Immunologie, Universit\u00e4t L\u00fcbeck","institution_ids":["https://openalex.org/I2801240073","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077426550","display_name":"Michael Roth","orcid":"https://orcid.org/0000-0002-8139-2821","observed_orcids":["https://orcid.org/0000-0002-8139-2821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027623509","display_name":"J Sch\u00f6lmerich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Sch\u00f6lmerich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018040201","display_name":"Renate Helfesrieder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Helfesrieder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019813616","display_name":"Jens L\u00fcdemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L\u00fcdemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770185","display_name":"Gross Wl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W L Gross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110304870","display_name":"Annegret Rautmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Rautmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112165106","display_name":"Peter Hh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H H Peter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.22273636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"1","first_page":"16","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anca","display_name":"ANCA","score":0.7260000109672546},{"id":"https://openalex.org/keywords/p-anca","display_name":"p-ANCA","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7630000114440918},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/granulomatosis-with-polyangiitis","display_name":"granulomatosis with polyangiitis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/colectomy","display_name":"colectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.6269999742507935},{"id":"https://openalex.org/keywords/proteinase-3","display_name":"proteinase 3","score":0.7059999704360962},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/anca-serology","display_name":"ANCA serology","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8312959671020508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7635490298271179},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6496610641479492},{"id":"https://openalex.org/C24040308","wikidata":"https://www.wikidata.org/wiki/Q574727","display_name":"Anti-neutrophil cytoplasmic antibody","level":4,"score":0.5896033048629761},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5739787817001343},{"id":"https://openalex.org/C21194631","wikidata":"https://www.wikidata.org/wiki/Q2113501","display_name":"Proteinase 3","level":4,"score":0.5341405272483826},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.5337299704551697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5266896486282349},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4894172251224518},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42284393310546875},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4162021577358246},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.35909414291381836},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35531383752822876},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.3528210520744324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3033517599105835}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1563754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1563754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunitat und Infektion","raw_type":"English Abstract"},{"id":"mag:2394911027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1563754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W173656396","https://openalex.org/W2048714549","https://openalex.org/W2321334020","https://openalex.org/W7044566708","https://openalex.org/W2013933308","https://openalex.org/W2007715568","https://openalex.org/W2011504371","https://openalex.org/W2149408285","https://openalex.org/W2041077832","https://openalex.org/W2059341107"],"abstract_inverted_index":{"Sera":[0],"of":[1,30,70,81,91,128,163],"108":[2],"patients":[3,35,75,137],"with":[4,36,76,138],"chronic":[5],"inflammatory":[6],"bowel":[7],"disease":[8,78,140,171],"(IBD)":[9],"and":[10,44,56,79,101,150,168,173],"13":[11],"control":[12,83],"sera":[13,32,73,84,95,132],"were":[14,120,134],"screened":[15],"for":[16,98,115],"antibodies":[17],"against":[18,118],"neutrophil":[19],"cytoplasmic":[20,58],"antigens":[21],"(ANCA)":[22],"by":[23],"an":[24],"indirect":[25],"immunofluorescence":[26],"test.":[27],"37":[28,130],"out":[29,127],"64":[31,93],"(58%)":[33],"from":[34,52,74,136],"ulcerative":[37],"colitis":[38],"(UC)":[39],"produced":[40],"a":[41,105],"fine":[42],"granular":[43,57],"perinuclear":[45],"ANCA":[46,59,159],"staining":[47],"pattern":[48],"(p-ANCA)":[49],"clearly":[50],"different":[51],"the":[53,71,82,92,109,123,129],"typically":[54],"diffuse":[55],"fluorescence":[60],"(c-ANCA)":[61],"seen":[62],"in":[63,108,122,165,169,176],"active":[64],"Wegener's":[65],"granulomatosis":[66],"(WG).":[67],"Only":[68,89],"1":[69,90],"44":[72],"Crohn's":[77],"none":[80],"showed":[85,104],"positive":[86,97,106],"p-ANCA":[87,142],"reactions.":[88],"CU":[94,124],"was":[96],"antinuclear":[99],"antibodies,":[100],"another":[102],"one":[103],"reaction":[107],"anti-proteinase-3":[110],"ELISA":[111],"which":[112],"is":[113],"specific":[114],"WG.":[116],"Antibodies":[117],"myeloperoxidase":[119],"negative":[121,145],"sera.":[125],"31":[126],"p-ANCA-positive":[131],"(84%)":[133],"obtained":[135],"high":[139],"activity.":[141],"titers":[143],"became":[144],"after":[146,151],"long-term":[147],"steroid":[148],"therapy":[149],"complete":[152],"colectomy.":[153],"These":[154],"preliminary":[155],"data":[156],"suggest":[157],"that":[158],"screening":[160],"may":[161],"be":[162],"value":[164],"differentiating":[166],"IBD":[167],"monitoring":[170],"activity":[172],"drug":[174],"effects":[175],"UC":[177],"patients.":[178]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
