{"id":"https://openalex.org/W2394906764","doi":"https://doi.org/10.1158/1557-3125.advbc15-a02","title":"Abstract A02: Stat3 plays a critical role in the establishment of immunosuppressive tumor microenvironment: Implications for tumor immunsurviellance and metastatic progression","display_name":"Abstract A02: Stat3 plays a critical role in the establishment of immunosuppressive tumor microenvironment: Implications for tumor immunsurviellance and metastatic progression","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2394906764","doi":"https://doi.org/10.1158/1557-3125.advbc15-a02","mag":"2394906764"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.advbc15-a02","doi":"https://doi.org/10.1158/1557-3125.advbc15-a02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc15-a02","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102705047","display_name":"Laura Jones","orcid":"https://orcid.org/0000-0003-4754-0349","observed_orcids":["https://orcid.org/0000-0003-4754-0349"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura M. Jones","raw_affiliation_strings":["1McGill, Montreal, QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1McGill, Montreal, QC, Canada,","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030263157","display_name":"Miranda L. Broz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda Broz","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109381507","display_name":"Jill J. Ranger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jill Ranger","raw_affiliation_strings":["1McGill, Montreal, QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1McGill, Montreal, QC, Canada,","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050189275","display_name":"Josie Ursini\u2010Siegel","orcid":"https://orcid.org/0000-0003-3242-3617","observed_orcids":["https://orcid.org/0000-0003-3242-3617"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Josie Ursini-Siegel","raw_affiliation_strings":["1McGill, Montreal, QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1McGill, Montreal, QC, Canada,","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018179968","display_name":"Matthew F. Krummel","orcid":"https://orcid.org/0000-0001-7915-3533","observed_orcids":["https://orcid.org/0000-0001-7915-3533"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Krummel","raw_affiliation_strings":["2UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027061409","display_name":"William J. Muller","orcid":"https://orcid.org/0000-0002-7293-4166","observed_orcids":["https://orcid.org/0000-0002-7293-4166"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William J. Muller","raw_affiliation_strings":["1McGill, Montreal, QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1McGill, Montreal, QC, Canada,","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"2_Supplement","first_page":"A02","last_page":"A02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0778999999165535,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7260000109672546},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6430000066757202},{"id":"https://openalex.org/keywords/mammary-tumor-progression","display_name":"mammary tumor progression","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-epithelium","display_name":"tumor epithelium","score":0.6480000019073486},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8360000252723694},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6480000019073486},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7628708481788635},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7547815442085266},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.6304320693016052},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5972328782081604},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5575950145721436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5420030951499939},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.5235202312469482},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.4552553594112396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4157545566558838},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3471667766571045},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2999788522720337},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.21770358085632324},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1509198248386383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.06719008088111877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.advbc15-a02","doi":"https://doi.org/10.1158/1557-3125.advbc15-a02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc15-a02","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2265030930","https://openalex.org/W6990752238","https://openalex.org/W2316498590","https://openalex.org/W1967663251","https://openalex.org/W2906736987","https://openalex.org/W7058143400","https://openalex.org/W2965118073","https://openalex.org/W1967923698","https://openalex.org/W3203080716","https://openalex.org/W1505531771"],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"surveillance":[2,33,197],"is":[3,79],"thought":[4],"to":[5,30,130],"play":[6],"a":[7,175,199,204,220,258],"critical":[8,221,259],"role":[9,90,222,260],"in":[10,75,81,93,101,165,203,223,261,285],"promoting":[11,82,224],"the":[12,28,49,54,71,76,89,95,102,142,160,166,207,238,262,279],"elimination":[13],"of":[14,20,37,51,70,91,105,111,119,162,168,178,206,217,264,278],"developing":[15],"malignant":[16],"lesions":[17,136,155],"through":[18],"activation":[19],"immune":[21,32,38,52,61,196,226],"response.":[22],"However,":[23,151],"cancer":[24],"cells":[25],"eventually":[26],"acquire":[27],"ability":[29],"escape":[31,59],"by":[34],"favoring":[35],"recruitment":[36],"cell":[39],"types":[40],"that":[41,57,68,123,213],"exert":[42],"an":[43,83,106,225],"inflammatory":[44],"and":[45,116,133,181,272],"immunosuppressive":[46,84,265],"state.":[47],"Despite":[48],"importance":[50],"surveillance,":[53],"molecular":[55],"mechanisms":[56],"promote":[58],"from":[60],"remains":[62],"poorly":[63],"defined.":[64],"Here":[65],"we":[66,98],"demonstrate":[67],"expression":[69,216],"Stat3":[72,92,100,124,186,191,218,256],"transcription":[73],"factor":[74],"tumor":[77,85,96,103,113,120,214,228,266,270],"epithelial":[78,149,215],"involved":[80],"microenvironment.":[86],"To":[87],"investigate":[88],"modulating":[94],"immune-microenvironment,":[97],"ablated":[99],"epithelia":[104],"inducible":[107],"PyV":[108],"mT":[109],"model":[110],"mammary":[112,163,193],"progression.":[114,274],"Molecular":[115],"pathological":[117],"analyses":[118],"progression":[121],"revealed":[122],"deficient":[125,187,192],"tumors":[126,164,194],"were":[127],"initially":[128],"able":[129],"form":[131],"hyperplastic":[132],"early":[134,153],"adenoma\u2013like":[135],"with":[137,174],"no":[138],"obvious":[139],"impact":[140],"on":[141,147,283],"proliferative":[143],"or":[144],"apoptotic":[145],"status":[146],"these":[148,152],"lesions.":[150,188],"premalignant":[154],"completely":[156],"regressed,":[157],"thereby":[158],"preventing":[159],"emergence":[161],"majority":[167],"animals.":[169,209],"Tumor":[170],"regression":[171],"was":[172,234],"correlated":[173],"massive":[176],"infiltration":[177],"T":[179],"lymphocytes":[180],"F4/80":[182],"positive":[183],"macrophages":[184],"into":[185],"However":[189],"focal":[190],"escaped":[195],"after":[198],"long":[200],"latency":[201],"period":[202],"minority":[205],"affected":[208],"Our":[210],"data":[211],"argue":[212],"plays":[219,257],"suppressive":[227],"microenvironment":[229],".":[230],"Note:":[231],"This":[232],"abstract":[233],"not":[235],"presented":[236],"at":[237],"conference.":[239],"Citation":[240],"Format:":[241],"Laura":[242],"M.":[243],"Jones,":[244],"Miranda":[245],"Broz,":[246],"Jill":[247],"Ranger,":[248],"Josie":[249],"Ursini-Siegel,":[250],"Matthew":[251],"Krummel,":[252],"William":[253],"J.":[254],"Muller.":[255],"establishment":[263],"microenvironment:":[267],"Implications":[268],"for":[269],"immunsurviellance":[271],"metastatic":[273],"[abstract].":[275],"In:":[276],"Proceedings":[277],"AACR":[280],"Special":[281],"Conference":[282],"Advances":[284],"Breast":[286],"Cancer":[287,298],"Research;":[288],"Oct":[289],"17-20,":[290],"2015;":[291],"Bellevue,":[292],"WA.":[293],"Philadelphia":[294],"(PA):":[295],"AACR;":[296],"Mol":[297],"Res":[299],"2016;14(2_Suppl):Abstract":[300],"nr":[301],"A02.":[302]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}