{"id":"https://openalex.org/W2394884517","doi":null,"title":"Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.","display_name":"Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2394884517","mag":"2394884517","pmid":"https://pubmed.ncbi.nlm.nih.gov/27186434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859887"},"language":"en","primary_location":{"id":"pmid:27186434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4859887/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089455074","display_name":"Mei\u2010Kuang Chen","orcid":"https://orcid.org/0000-0001-8027-8990","observed_orcids":["https://orcid.org/0000-0001-8027-8990"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei-Kuang Chen","raw_affiliation_strings":["Graduate School of Biomedical Science, The University of Texas Health Science Center at HoustonHouston, Texas 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Science, The University of Texas Health Science Center at HoustonHouston, Texas 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076834432","display_name":"Mien\u2010Chie Hung","orcid":"https://orcid.org/0000-0003-4317-4740","observed_orcids":["https://orcid.org/0000-0003-4317-4740"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Mien-Chie Hung","raw_affiliation_strings":["Graduate School of Biomedical Science, The University of Texas Health Science Center at HoustonHouston, Texas 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas, 77030, USA; Center of Molecular Medicine and Graduate Institute of Cancer Biology, China Medical UniversityTaichung 404, Taiwan; Department of Biotechnology, Asia UniversityTaichung 413, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Science, The University of Texas Health Science Center at HoustonHouston, Texas 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas, 77030, USA; Center of Molecular Medicine and Graduate Institute of Cancer Biology, China Medical UniversityTaichung 404, Taiwan; Department of Biotechnology, Asia UniversityTaichung 413, Taiwan","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I143578492","https://openalex.org/I184693016","https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2803,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78583778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"4","first_page":"827","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8960000276565552},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibitors","display_name":"receptor tyrosine kinase inhibitors","score":0.6589999794960022},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.765999972820282},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6620000004768372},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.7806068062782288},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7270379066467285},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.685147225856781},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5551681518554688},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5313877463340759},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48230981826782227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4746564030647278},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47268182039260864},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4697454571723938},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.456832617521286},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4510398209095001},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4319779872894287},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2341565191745758},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20087102055549622},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13096359372138977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07413896918296814}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:27186434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4859887","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4859887/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:2394884517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4859887","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4859887/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3893293991","display_name":"Tumor Progression of Nuclear EGFR in Breast Cancer","funder_award_id":"R01CA109311","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7043661956","display_name":"Growth Factor Receptor in Breast Cancer Progression and Metabolic Regulation","funder_award_id":"P01CA099031","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W136863196","https://openalex.org/W967487999","https://openalex.org/W1490790087","https://openalex.org/W1513083741","https://openalex.org/W1567221268","https://openalex.org/W1695826798","https://openalex.org/W1752089945","https://openalex.org/W1755658704","https://openalex.org/W1781111633","https://openalex.org/W1816896904","https://openalex.org/W1877328105","https://openalex.org/W1894612901","https://openalex.org/W1908561757","https://openalex.org/W1963528972","https://openalex.org/W1963972004","https://openalex.org/W1964071325","https://openalex.org/W1964957202","https://openalex.org/W1965057195","https://openalex.org/W1965710516","https://openalex.org/W1966834115","https://openalex.org/W1967457266","https://openalex.org/W1967494335","https://openalex.org/W1968366677","https://openalex.org/W1969527608","https://openalex.org/W1970925815","https://openalex.org/W1973323865","https://openalex.org/W1979361881","https://openalex.org/W1979691996","https://openalex.org/W1983499602","https://openalex.org/W1984266465","https://openalex.org/W1984919526","https://openalex.org/W1985580777","https://openalex.org/W1987281549","https://openalex.org/W1988680523","https://openalex.org/W1988684866","https://openalex.org/W1988716393","https://openalex.org/W1989223905","https://openalex.org/W1992139451","https://openalex.org/W1995134244","https://openalex.org/W1995577291","https://openalex.org/W1996457137","https://openalex.org/W1997927846","https://openalex.org/W1998203489","https://openalex.org/W2000980666","https://openalex.org/W2003565881","https://openalex.org/W2004368310","https://openalex.org/W2007000115","https://openalex.org/W2007150397","https://openalex.org/W2008046307","https://openalex.org/W2009214383","https://openalex.org/W2010022150","https://openalex.org/W2011963129","https://openalex.org/W2012790791","https://openalex.org/W2013858874","https://openalex.org/W2020944344","https://openalex.org/W2021373965","https://openalex.org/W2029935304","https://openalex.org/W2033344009","https://openalex.org/W2036342252","https://openalex.org/W2039195763","https://openalex.org/W2039525991","https://openalex.org/W2041058556","https://openalex.org/W2043346845","https://openalex.org/W2043980090","https://openalex.org/W2044570206","https://openalex.org/W2045153367","https://openalex.org/W2045897464","https://openalex.org/W2050295457","https://openalex.org/W2051570504","https://openalex.org/W2056498488","https://openalex.org/W2056778664","https://openalex.org/W2057706543","https://openalex.org/W2061001563","https://openalex.org/W2061139019","https://openalex.org/W2064778055","https://openalex.org/W2070732456","https://openalex.org/W2073127457","https://openalex.org/W2075917608","https://openalex.org/W2077109689","https://openalex.org/W2077813812","https://openalex.org/W2082163215","https://openalex.org/W2087032518","https://openalex.org/W2088388419","https://openalex.org/W2090800692","https://openalex.org/W2091827806","https://openalex.org/W2095264331","https://openalex.org/W2096136751","https://openalex.org/W2096386297","https://openalex.org/W2097091656","https://openalex.org/W2099952417","https://openalex.org/W2100647031","https://openalex.org/W2102003117","https://openalex.org/W2106951948","https://openalex.org/W2107112594","https://openalex.org/W2109399507","https://openalex.org/W2110017381","https://openalex.org/W2111624138","https://openalex.org/W2111693820","https://openalex.org/W2112964045","https://openalex.org/W2113382133","https://openalex.org/W2116012295","https://openalex.org/W2118113452","https://openalex.org/W2118211359","https://openalex.org/W2121419775","https://openalex.org/W2121828618","https://openalex.org/W2124195241","https://openalex.org/W2124215787","https://openalex.org/W2127147625","https://openalex.org/W2127808743","https://openalex.org/W2140345256","https://openalex.org/W2140777225","https://openalex.org/W2145200068","https://openalex.org/W2146331622","https://openalex.org/W2147338625","https://openalex.org/W2149865900","https://openalex.org/W2152780905","https://openalex.org/W2154111088","https://openalex.org/W2154889628","https://openalex.org/W2157624835","https://openalex.org/W2158819778","https://openalex.org/W2160595349","https://openalex.org/W2161340431","https://openalex.org/W2164995160","https://openalex.org/W2166775075","https://openalex.org/W2167356883","https://openalex.org/W2170298709","https://openalex.org/W2176781343","https://openalex.org/W2270704840","https://openalex.org/W2335220422","https://openalex.org/W4239885211"],"related_works":["https://openalex.org/W3164370300","https://openalex.org/W7134125189","https://openalex.org/W3011469361","https://openalex.org/W1974142660","https://openalex.org/W2613182316","https://openalex.org/W4401593620","https://openalex.org/W74486590","https://openalex.org/W7171397491","https://openalex.org/W4353015074","https://openalex.org/W6996125845"],"abstract_inverted_index":{"In":[0,154,174],"response":[1,12],"to":[2,7,17,43,65,69,143,150,168],"DNA":[3,10,34,90,134],"damage":[4,11,91],"lesions":[5],"due":[6],"cellular":[8],"stress,":[9],"(DDR)":[13],"pathways":[14,93,187],"are":[15,122],"activated":[16],"promote":[18],"cell":[19,27,46,50,86,96],"survival":[20,87],"and":[21,40,48,94,116,137,160,188],"genetic":[22],"stability":[23],"or":[24],"unrepaired":[25],"lesion-induced":[26],"death.":[28],"Current":[29],"cancer":[30,45,61,78,131],"treatments":[31],"predominantly":[32],"utilize":[33],"damaging":[35,135],"agents,":[36],"such":[37],"as":[38,166],"irradiation":[39],"chemotherapy":[41],"drugs,":[42],"inhibit":[44],"proliferation":[47],"induce":[49],"death":[51],"through":[52],"the":[53,100,127,145,151,179,185,189],"activation":[54],"of":[55,60,104,113,147,157,182],"DDR.":[56],"However,":[57],"a":[58],"portion":[59],"patients":[62,170],"is":[63,80,109,141],"reported":[64,110],"develop":[66],"therapeutic":[67],"resistance":[68,75],"these":[70],"DDR-inducing":[71],"agents.":[72],"One":[73],"significant":[74],"mechanism":[76],"in":[77,111,124,130],"cells":[79],"oncogenic":[81,101],"kinase":[82],"overexpression,":[83],"which":[84],"promotes":[85],"by":[88],"enhancing":[89],"repair":[92],"evading":[95],"cycle":[97],"arrest.":[98],"Among":[99],"kinases,":[102],"overexpression":[103],"receptor":[105],"tyrosine":[106],"kinases":[107],"(RTKs)":[108],"many":[112],"solid":[114],"tumors,":[115],"numerous":[117],"clinical":[118],"trials":[119],"targeting":[120],"RTKs":[121,148,183],"currently":[123],"progress.":[125],"As":[126],"emerging":[128,190],"trend":[129],"treatment":[132],"combines":[133],"agents":[136],"RTK":[138,158],"inhibitors,":[139],"it":[140],"important":[142],"understand":[144],"substrates":[146,163],"relative":[149],"DDR":[152,186],"pathways.":[153],"addition,":[155],"alteration":[156],"expression":[159],"their":[161],"phosphorylated":[162],"can":[164],"serve":[165],"biomarkers":[167,191],"stratify":[169],"for":[171,192],"combination":[172],"therapies.":[173],"this":[175],"review,":[176],"we":[177],"summarize":[178],"deleterious":[180],"effects":[181],"on":[184],"personalized":[193],"therapy.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
