{"id":"https://openalex.org/W2394870648","doi":null,"title":"[Protective functions of recombinant protein targeted at RANKL against hepatic ischemia/reperfusion injury transfected by retrovirus in mice].","display_name":"[Protective functions of recombinant protein targeted at RANKL against hepatic ischemia/reperfusion injury transfected by retrovirus in mice].","publication_year":2011,"publication_date":"2011-10-18","ids":{"openalex":"https://openalex.org/W2394870648","mag":"2394870648","pmid":"https://pubmed.ncbi.nlm.nih.gov/22321985"},"language":"zh","primary_location":{"id":"pmid:22321985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22321985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100754566","display_name":"Jian Shi","orcid":"https://orcid.org/0000-0003-3255-8263","observed_orcids":["https://orcid.org/0000-0003-3255-8263"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Shi","raw_affiliation_strings":["Affiliated Hospital, Binzhou Medical College, Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital, Binzhou Medical College, Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434120","display_name":"Xiaohua Li","orcid":"https://orcid.org/0000-0002-8051-2617","observed_orcids":["https://orcid.org/0000-0002-8051-2617"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-hua Li","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014017713","display_name":"Beicheng Sun","orcid":"https://orcid.org/0000-0002-8657-7024","observed_orcids":["https://orcid.org/0000-0002-8657-7024","https://orcid.org/0000-0001-7696-703X"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bei-cheng Sun","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042285491","display_name":"Xutao Lin","orcid":"https://orcid.org/0000-0002-7110-3459","observed_orcids":["https://orcid.org/0000-0002-7110-3459"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu-tao Lin","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630664","display_name":"Xingyuan Zhang","orcid":"https://orcid.org/0009-0004-3866-8863","observed_orcids":["https://orcid.org/0009-0004-3866-8863"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-yuan Zhang","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403517","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0002-8813-2627","observed_orcids":["https://orcid.org/0000-0002-8813-2627"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112130336","display_name":"Kun Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Ou","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103188016","display_name":"Qiangpu Chen","orcid":"https://orcid.org/0000-0002-5963-9584","observed_orcids":["https://orcid.org/0000-0002-5963-9584"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]},{"id":"https://openalex.org/I4210092954","display_name":"Binzhou Medical College Hospital","ror":"https://ror.org/00gn3nj37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang-pu Chen","raw_affiliation_strings":["Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affliated Hospital, Binzhou Medical College,Shandong Province, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294","https://openalex.org/I4210092954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3269,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70472533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"91","issue":"38","first_page":"2719","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8270000219345093},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hydrodynamic-transfection","display_name":"hydrodynamic transfection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/jnk-phosphorylation","display_name":"JNK phosphorylation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8949999809265137},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7139999866485596},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.3970000147819519},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6722682118415833},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6240129470825195},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.54903644323349},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.5486099720001221},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.517890453338623},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5119917988777161},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48587435483932495},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4632495641708374},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.44795501232147217},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4193590581417084},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4186163544654846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37557047605514526},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3742983043193817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35125112533569336},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.34126022458076477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3365367352962494},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3233552873134613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2200208604335785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12475922703742981},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12453827261924744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07659313082695007}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22321985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22321985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},{"id":"mag:2394870648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22321985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1801410338","https://openalex.org/W1991588322","https://openalex.org/W1608015476","https://openalex.org/W2354217411","https://openalex.org/W2387931252","https://openalex.org/W7097996588","https://openalex.org/W2998177886","https://openalex.org/W2148337958","https://openalex.org/W2589388448","https://openalex.org/W2007932315"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,71,98,102,136,156,208,231,266,293,319,353],"protective":[4,337],"functions":[5,264,338],"of":[6,73,88,104,138,158,163,178,189,295,321,355],"recombinant":[7],"protein":[8],"RANK-Fc":[9,91,142,245,260,335],"against":[10,339],"hepatic":[11,75,159,340],"ischemia/reperfusion":[12,76,341],"injury":[13,342],"and":[14,44,92,108,120,150,173,194,246,305,325,358],"clarify":[15],"its":[16],"possible":[17],"mechanism.":[18],"METHODS:":[19],"Sixty":[20],"male":[21],"Balb/c":[22],"mice":[23,51],"were":[24,52,111,153,197,228,248,315],"randomly":[25],"divided":[26],"into":[27],"3":[28,69],"groups":[29,223],"according":[30],"to":[31],"different":[32,86,114],"treatments:":[33],"serum-free":[34],"medium":[35],"control":[36],"(Sham)":[37],"group,":[38,259],"target":[39],"gene":[40],"retrovirus":[41,47],"(RANK-Fc)":[42],"group":[43,96],"empty":[45],"vector":[46],"(eGFP)":[48],"group.":[49,333],"All":[50],"injected":[53],"with":[54,257,352],"2.5":[55],"ml":[56],"solution":[57],"(with":[58],"or":[59],"without":[60,101],"retrovirus)":[61],"within":[62],"6":[63,119],"seconds":[64],"via":[65],"tail":[66],"vein.":[67],"After":[68],"days,":[70],"model":[72],"70%":[74],"was":[77,133,143,168,180,205,238],"induced":[78],"under":[79],"warm":[80],"conditions":[81],"for":[82,135,155,236],"90":[83],"minutes":[84],"after":[85,253],"periods":[87],"reperfusion":[89],"in":[90,126,165,251,331,343],"eGFP":[93,139,247,258],"groups;":[94],"Sham":[95],"underwent":[97],"same":[99,267],"procedure":[100],"occlusion":[103],"blood":[105],"supply.":[106],"Blood":[107],"liver":[109,166,252,263],"samples":[110],"obtained":[112],"at":[113,224,265,348],"time":[115,226,268],"points":[116],"(1,":[117],"3,":[118],"24":[121],"h;":[122],"n":[123],"=":[124,278,286,300,308],"5":[125],"each).":[127],"Reverse":[128],"transcription-polymerase":[129],"chain":[130],"reaction":[131],"(RT-PCR)":[132],"used":[134,154],"evaluation":[137,157],"mRNA":[140],"expression.":[141],"assessed":[144,182],"by":[145,170,183,199,207,230,240],"Western":[146,171,184],"blot.":[147,185],"Liver":[148,186],"transaminases":[149],"histopathological":[151],"changes":[152],"injury.":[160],"The":[161,175,218],"activity":[162],"NF-\u03baB":[164,274,357],"nucleus":[167],"analyzed":[169],"blot":[172],"immunohistochemistry.":[174],"activation":[176],"level":[177],"JNK":[179,283,360],"also":[181],"homogenate":[187],"levels":[188],"tumor":[190],"necrosis":[191],"factor":[192],"(TNF)-\u03b1":[193],"interleukin":[195],"(IL)-6":[196],"detected":[198,229],"enzyme-linked":[200],"immunosorbent":[201],"assay":[202],"(ELISA).":[203],"Apoptosis":[204],"identified":[206],"terminal":[209],"deoxynucleotidyl":[210],"transferase":[211],"dUTP":[212],"nick":[213],"end":[214],"labeling":[215],"(TUNEL)":[216],"analysis.":[217],"differences":[219],"between":[220],"three":[221],"treatment":[222],"each":[225],"point":[227,269],"one-way":[232],"ANOVA.":[233],"Statistical":[234],"analysis":[235],"inter-comparison":[237],"performed":[239],"Student's":[241],"t":[242],"test.":[243],"RESULTS:":[244],"successfully":[249],"expressed":[250],"hydrodynamics-based":[254],"transfection.":[255],"Compared":[256],"significantly":[261],"improved":[262],"(P":[270],"<":[271,281,289,303,311],"0.01),":[272],"decreased":[273,330],"nuclear":[275],"translocation":[276],"(t":[277,285,299,307],"6.726,":[279],"P":[280,288,302,310],"0.01)and":[282,290],"phosphorylation":[284],"6.713,":[287],"obviously":[291],"suppressed":[292],"release":[294],"pro-inflammatory":[296],"cytokine":[297],"TNF-\u03b1":[298],"4.779,":[301],"0.01)":[304],"IL-6":[306],"5.482,":[309],"0.01).":[312],"Morphological":[313],"injuries":[314],"markedly":[316],"alleviated":[317],"while":[318],"expressions":[320],"immunohistochemical":[322],"positive":[323,328],"cells":[324,329],"TUNEL":[326],"staining":[327],"RANF-Fc":[332],"CONCLUSION:":[334],"has":[336],"mice.":[344],"Its":[345],"mechanism":[346],"is":[347],"least":[349],"partially":[350],"related":[351],"suppressions":[354],"proinflammatory":[356],"proapoptotic":[359],"signaling":[361],"pathways.":[362]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}