{"id":"https://openalex.org/W2394861855","doi":null,"title":"In vitro profiling against ion channels beyond hERG as an early indicator of cardiac risk.","display_name":"In vitro profiling against ion channels beyond hERG as an early indicator of cardiac risk.","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2394861855","mag":"2394861855","pmid":"https://pubmed.ncbi.nlm.nih.gov/19479660"},"language":"en","primary_location":{"id":"pmid:19479660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19479660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019127391","display_name":"Mao Xiang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mao Xiang Chen","raw_affiliation_strings":["GlaxoSmithKline plc, Biological Reagents & Assay Development, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline plc, Biological Reagents & Assay Development, Hertfordshire, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030040108","display_name":"R. M. Helliwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ray M Helliwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082846","display_name":"Jeff J. Clare","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff J Clare","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0785,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81559819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"11","issue":"3","first_page":"269","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acquired-long-qt-syndrome","display_name":"acquired long QT syndrome","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.7170000076293945},{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.9160000085830688},{"id":"https://openalex.org/keywords/automated-patch-clamp","display_name":"automated patch clamp","score":0.9290000200271606},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cardiac-risk-prediction","display_name":"cardiac risk prediction","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.9648360013961792},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.6965246200561523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5154743790626526},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5050294995307922},{"id":"https://openalex.org/C2776190711","wikidata":"https://www.wikidata.org/wiki/Q7398663","display_name":"Safety pharmacology","level":3,"score":0.48837417364120483},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.46283507347106934},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3830997943878174},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3465685248374939},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33945953845977783},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.26557493209838867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2400003969669342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18604609370231628},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.18044644594192505},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08495447039604187},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:19479660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19479660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W560133699","https://openalex.org/W2427197905","https://openalex.org/W1992549522","https://openalex.org/W2204300761","https://openalex.org/W2050678123","https://openalex.org/W1484110055","https://openalex.org/W1979395612","https://openalex.org/W2150275204","https://openalex.org/W2065682273","https://openalex.org/W1599693565"],"abstract_inverted_index":{"Acquired":[0],"long":[1],"QT":[2],"syndrome":[3],"is":[4,82],"a":[5],"major":[6],"cause":[7],"of":[8,14,43,64,78,86,115,137,144,152],"drug":[9],"withdrawals":[10],"and":[11,28,30,71,108,155],"the":[12,44,60,92,112,131,134,160],"failure":[13],"compounds":[15,88,110],"during":[16],"development.":[17,116],"Traditionally,":[18],"in":[19,49,149,159],"vitro":[20,150],"cardiac":[21,119,138,153],"liability":[22,62],"screens":[23],"have":[24,31,58],"been":[25,123],"low":[26],"throughput":[27,70],"expensive,":[29],"used":[32],"primary":[33,76],"animal":[34],"cells":[35],"or":[36],"tissues":[37],"that":[38],"are":[39],"not":[40],"necessarily":[41],"predictive":[42],"human":[45],"heart.":[46],"Recent":[47],"advances":[48],"ion":[50,66],"channel":[51],"assay":[52],"technologies,":[53],"particularly":[54],"automated":[55],"patch":[56],"clamp,":[57],"enabled":[59],"early":[61,135],"screening":[63,81,93,121,136],"individual":[65],"channels":[67,139],"at":[68],"medium-to-high":[69],"with":[72],"acceptable":[73],"fidelity.":[74],"The":[75],"aim":[77],"this":[79],"first-tier":[80],"to":[83,100,104],"aid":[84],"prioritization":[85],"early-stage":[87],"for":[89,133,148],"progression":[90],"along":[91],"cascade.":[94],"Potential":[95],"liabilities":[96],"can":[97],"be":[98,105],"flagged":[99],"enable":[101],"follow-up":[102],"studies":[103],"initiated":[106],"if":[107],"when":[109],"approach":[111],"costlier":[113],"stages":[114],"To":[117],"date,":[118],"safety":[120],"has":[122],"focused":[124],"on":[125],"hERG":[126,141],"channel.":[127],"This":[128],"article":[129],"examines":[130],"rationale":[132],"beyond":[140],"as":[142],"part":[143],"an":[145],"integrated":[146],"strategy":[147],"evaluation":[151],"risk,":[154],"reviews":[156],"recent":[157],"developments":[158],"relevant":[161],"technologies.":[162]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}