{"id":"https://openalex.org/W2394815976","doi":"https://doi.org/10.4155/bio-2015-0036","title":"Simultaneous Determination of Levonorgestrel and Two Endogenous Sex Hormones in Human Plasma Based on LC\u2013MS/MS","display_name":"Simultaneous Determination of Levonorgestrel and Two Endogenous Sex Hormones in Human Plasma Based on LC\u2013MS/MS","publication_year":2016,"publication_date":"2016-05-23","ids":{"openalex":"https://openalex.org/W2394815976","doi":"https://doi.org/10.4155/bio-2015-0036","mag":"2394815976","pmid":"https://pubmed.ncbi.nlm.nih.gov/27211854"},"language":"en","primary_location":{"id":"doi:10.4155/bio-2015-0036","doi":"https://doi.org/10.4155/bio-2015-0036","is_oa":false,"landing_page_url":"https://doi.org/10.4155/bio-2015-0036","pdf_url":null,"source":{"id":"https://openalex.org/S159955403","display_name":"Bioanalysis","issn_l":"1757-6180","issn":["1757-6180","1757-6199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008712174","display_name":"Rulin Wang","orcid":"https://orcid.org/0009-0005-3509-4291","observed_orcids":["https://orcid.org/0009-0005-3509-4291"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rulin Wang","raw_affiliation_strings":["Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027143310","display_name":"Yuan Tian","orcid":"https://orcid.org/0000-0001-7174-3299","observed_orcids":["https://orcid.org/0000-0001-7174-3299"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Tian","raw_affiliation_strings":["Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101592007","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0001-6524-328X","observed_orcids":["https://orcid.org/0000-0001-6524-328X"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035230736","display_name":"Zunjian Zhang","orcid":"https://orcid.org/0000-0001-9446-9237","observed_orcids":["https://orcid.org/0000-0001-9446-9237"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zunjian Zhang","raw_affiliation_strings":["Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China","State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing210009, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing210009, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9127,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67780738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"8","issue":"11","first_page":"1133","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levonorgestrel","display_name":"levonorgestrel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":1.0},{"id":"https://openalex.org/keywords/endogenous-sex-hormones","display_name":"endogenous sex hormones","score":0.953000009059906},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.7289999723434448},{"id":"https://openalex.org/keywords/emergency-contraception","display_name":"emergency contraception","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2780186607","wikidata":"https://www.wikidata.org/wiki/Q416950","display_name":"Levonorgestrel","level":5,"score":0.9336645603179932},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6426657438278198},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5606229305267334},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.5092974901199341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49584564566612244},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48889556527137756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4612383544445038},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4296623468399048},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.19369477033615112},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.1051206886768341},{"id":"https://openalex.org/C2779076696","wikidata":"https://www.wikidata.org/wiki/Q1280670","display_name":"Family planning","level":4,"score":0.08374986052513123},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.0828828513622284},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016912","descriptor_name":"Levonorgestrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016912","descriptor_name":"Levonorgestrel","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4155/bio-2015-0036","doi":"https://doi.org/10.4155/bio-2015-0036","is_oa":false,"landing_page_url":"https://doi.org/10.4155/bio-2015-0036","pdf_url":null,"source":{"id":"https://openalex.org/S159955403","display_name":"Bioanalysis","issn_l":"1757-6180","issn":["1757-6180","1757-6199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"journal-article"},{"id":"pmid:27211854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27211854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1513596312","https://openalex.org/W1542566870","https://openalex.org/W1985688418","https://openalex.org/W1993163033","https://openalex.org/W1996170975","https://openalex.org/W2016200212","https://openalex.org/W2018452033","https://openalex.org/W2030555662","https://openalex.org/W2032479107","https://openalex.org/W2033358864","https://openalex.org/W2037629853","https://openalex.org/W2038669670","https://openalex.org/W2048899801","https://openalex.org/W2051777328","https://openalex.org/W2076702065","https://openalex.org/W2090837632","https://openalex.org/W2091463060","https://openalex.org/W2135574948","https://openalex.org/W2142037633","https://openalex.org/W2145886183","https://openalex.org/W2149966304","https://openalex.org/W2151009640","https://openalex.org/W2151996036","https://openalex.org/W2152465522","https://openalex.org/W2156305259","https://openalex.org/W2328694593","https://openalex.org/W2409434575"],"related_works":["https://openalex.org/W2360833088","https://openalex.org/W2791452316","https://openalex.org/W2319307815","https://openalex.org/W2189034578","https://openalex.org/W2000177525","https://openalex.org/W2150629314","https://openalex.org/W2555150566","https://openalex.org/W336332476","https://openalex.org/W2348527565","https://openalex.org/W7201850149"],"abstract_inverted_index":{"BACKGROUND:":[0],"Levonorgestrel":[1],"(LNG)":[2],"is":[3],"a":[4,28],"commonly":[5],"used":[6],"emergency":[7],"contraceptive":[8],"which":[9],"can":[10],"effect":[11],"sex":[12,37,104],"hormone":[13,38,105],"levels":[14,39,106,129,136],"in":[15,43,74,107,137],"female":[16,44,110],"blood.":[17],"The":[18,53,92],"objective":[19],"of":[20,48,77,103,116],"this":[21],"study":[22],"was":[23,55],"to":[24,61,98],"develop":[25],"and":[26,30,41,58,89,127,132],"validate":[27],"specific":[29],"sensitive":[31],"LC-MS/MS":[32],"method":[33,54,93],"for":[34,80,87],"monitoring":[35],"endogenous":[36],"(17\u03b2-estradiol":[40],"progesterone)":[42],"plasma":[45,112],"after":[46,113],"administration":[47,115],"LNG.":[49],"Results":[50],"&":[51],"methodology:":[52],"developed,":[56],"optimized":[57],"validated":[59],"according":[60],"the":[62,69,75,100,138],"EMA":[63],"guideline.":[64],"Assay":[65],"validation":[66],"met":[67],"all":[68],"criteria,":[70],"including":[71],"good":[72],"linearity":[73],"range":[76],"0.1-20":[78],"ng/ml":[79,86],"17\u03b2-estradiol,":[81],"as":[82,84],"well":[83],"0.2-30":[85],"LNG":[88,119,122],"progesterone.":[90],"CONCLUSION:":[91],"has":[94],"been":[95],"preliminarily":[96],"applied":[97],"explore":[99],"variation":[101],"trend":[102],"healthy":[108],"Chinese":[109],"volunteers'":[111],"oral":[114],"1.5":[117],"mg":[118],"tablet.":[120],"With":[121],"absorption":[123],"into":[124],"plasma,":[125],"progesterone":[126],"estradiol":[128],"descended":[130],"rapidly,":[131],"maintained":[133],"at":[134],"low":[135],"onset":[139],"time.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
