{"id":"https://openalex.org/W2394815906","doi":null,"title":"Efficacy and tolerability of azelastine nasal spray in patients with allergic rhinitis compared to placebo and budesonide.","display_name":"Efficacy and tolerability of azelastine nasal spray in patients with allergic rhinitis compared to placebo and budesonide.","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W2394815906","mag":"2394815906","pmid":"https://pubmed.ncbi.nlm.nih.gov/8105785"},"language":"en","primary_location":{"id":"pmid:8105785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8105785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038028827","display_name":"P Dorow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Dorow","raw_affiliation_strings":["German Red Cross Hospital Mark-Brandenburg, Berlin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Red Cross Hospital Mark-Brandenburg, Berlin","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009043561","display_name":"Rudolf Aurich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Aurich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016688209","display_name":"Ursula Petzold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Petzold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4658,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.60723237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"43","issue":"8","first_page":"909","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azelastine","display_name":"azelastine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/budesonide","display_name":"budesonide","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.6669999957084656},{"id":"https://openalex.org/keywords/sneezing","display_name":"sneezing","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nasal-itching","display_name":"nasal itching","score":0.9409999847412109},{"id":"https://openalex.org/keywords/rhinorrhea","display_name":"rhinorrhea","score":0.925000011920929},{"id":"https://openalex.org/keywords/nasal-obstruction","display_name":"nasal obstruction","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ocular-symptoms","display_name":"ocular symptoms","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C2780113039","wikidata":"https://www.wikidata.org/wiki/Q419820","display_name":"Azelastine","level":2,"score":0.9751984477043152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9098570942878723},{"id":"https://openalex.org/C2776136866","wikidata":"https://www.wikidata.org/wiki/Q422212","display_name":"Budesonide","level":3,"score":0.804240345954895},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7811638712882996},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.744411289691925},{"id":"https://openalex.org/C2780973058","wikidata":"https://www.wikidata.org/wiki/Q1755275","display_name":"Nasal spray","level":3,"score":0.668148398399353},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6306747198104858},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5833473205566406},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4977007210254669},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.43886059522628784},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4017043113708496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3830317258834839},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22057780623435974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13540804386138916},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.1058928370475769},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019819","descriptor_name":"Budesonide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8105785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8105785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},{"id":"mag:2394815906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8105785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996276635","https://openalex.org/W2062061217","https://openalex.org/W36745666","https://openalex.org/W2084304346","https://openalex.org/W1862920033","https://openalex.org/W2414039205","https://openalex.org/W122106923","https://openalex.org/W2337335142","https://openalex.org/W1964793566","https://openalex.org/W180119566"],"abstract_inverted_index":{"The":[0],"efficacy":[1],"and":[2,30,48,53,98,212],"safety":[3],"of":[4,16,45,50,58,80,91,111,122,160,167,174,215],"a":[5,23,70,144],"new":[6],"antiallergic":[7],"drug,":[8],"intranasal":[9,149],"azelastine":[10,75,150,207],"(CAS":[11,38],"58581-89-8),":[12],"in":[13,22,43,77,103,164],"the":[14,56,64,92,106,120,123,141],"treatment":[15,73,147,211],"seasonal":[17],"allergic":[18,51],"rhinitis":[19,52,168],"was":[20,41,151],"investigated":[21],"16":[24],"patient":[25,33],"double-blind":[26],"comparison":[27,35],"with":[28,36,74,148,197],"placebo":[29,69,132,210],"another":[31],"36":[32],"open":[34],"budesonide":[37,158],"51333-22-3).":[39],"Efficacy":[40],"assessed":[42],"terms":[44],"13":[46],"signs":[47,166],"symptoms":[49,108,195],"tolerability":[54],"on":[55],"basis":[57],"spontaneously":[59],"reported":[60],"adverse":[61],"events.":[62],"In":[63,140],"first":[65],"study,":[66],"compared":[67],"to":[68,115,119,135,154,218],"one":[71,170],"week's":[72,171],"resulted":[76],"substantial":[78],"relief":[79],"sneezing":[81],"(p":[82,87,95,100,137],"=":[83,88,96,101,138],"0.009),":[84,89],"nasal":[85,93,179],"itching":[86],"swelling":[90],"mucosa":[94],"0.067)":[97],"rhinorrhoea":[99],"0.262)":[102],"patients":[104,128,161],"having":[105],"above":[107],"at":[109,112],"baseline":[110],"least":[113],"moderate":[114],"severe":[116],"intensity.":[117],"According":[118],"judgement":[121],"supervising":[124],"physician,":[125],"7/8":[126],"azelastine-treated":[127],"but":[129,189],"none":[130],"receiving":[131],"responded":[133],"well":[134],"therapy":[136,172],"0.001).":[139],"second":[142],"study":[143],"two":[145],"weeks'":[146],"found":[152],"not":[153,190,202],"differ":[155],"significantly":[156],"from":[157],"67%":[159],"showed":[162],"improvement":[163],"principal":[165],"after":[169],"irrespective":[173],"treatment.":[175,219],"Nasal":[176],"symptoms,":[177],"including":[178],"obstruction,":[180],"were":[181,213],"most":[182],"markedly":[183],"improved":[184],"by":[185],"both":[186],"treatments.":[187],"Azelastine,":[188],"budesonide,":[191],"also":[192],"relieved":[193],"ocular":[194],"associated":[196],"rhinitis.":[198],"Adverse":[199],"events":[200],"did":[201],"occur":[203],"more":[204],"frequently":[205],"under":[206,209],"than":[208],"often":[214],"uncertain":[216],"relationship":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
