{"id":"https://openalex.org/W2394811827","doi":null,"title":"Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model?","display_name":"Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model?","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2394811827","mag":"2394811827","pmid":"https://pubmed.ncbi.nlm.nih.gov/2267673"},"language":"en","primary_location":{"id":"pmid:2267673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2267673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101971228","display_name":"Ajay Kumar Verma","orcid":"https://orcid.org/0000-0002-0772-105X","observed_orcids":["https://orcid.org/0000-0002-0772-105X"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Verma","raw_affiliation_strings":["Islet cell Transplantation Study Group, All India Institute of Medical Sciences, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islet cell Transplantation Study Group, All India Institute of Medical Sciences, New Delhi","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040811919","display_name":"Amit Kumar Dinda","orcid":"https://orcid.org/0000-0002-0681-1635","observed_orcids":["https://orcid.org/0000-0002-0681-1635"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Dinda","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064979397","display_name":"Chitra Sarkar","orcid":"https://orcid.org/0000-0002-4315-9316","observed_orcids":["https://orcid.org/0000-0002-4315-9316"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C Sarkar","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072477025","display_name":"Rashmi Fotedar","orcid":"https://orcid.org/0000-0003-3983-3643","observed_orcids":["https://orcid.org/0000-0003-3983-3643"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R Fotedar","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043694406","display_name":"I K Dhawan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"I K Dhawan","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L K Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"L K Sharma","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018440972","display_name":"K Khetarpal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K Khetarpal","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032502482","display_name":"Arun Fotedar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Fotedar","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022508556","display_name":"Sathyanarayana Srikanta","orcid":"https://orcid.org/0000-0002-8774-8673","observed_orcids":["https://orcid.org/0000-0002-8774-8673"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Srikanta","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067261699","display_name":"N Kochupillai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N Kochupillai","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi,","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63739035"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27991291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"3","first_page":"148","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/polyacrylamide-hydrogel","display_name":"polyacrylamide hydrogel","score":0.8050000071525574},{"id":"https://openalex.org/keywords/necrotizing-pancreatitis","display_name":"necrotizing pancreatitis","score":0.890999972820282},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3019999861717224},{"id":"https://openalex.org/keywords/islet-isolation","display_name":"islet isolation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/graft-site","display_name":"graft site","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6511228680610657},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6189596652984619},{"id":"https://openalex.org/C2778881546","wikidata":"https://www.wikidata.org/wiki/Q1752136","display_name":"Renal capsule","level":3,"score":0.6127105355262756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5926405787467957},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5717563033103943},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5152652263641357},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5017130374908447},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.488311767578125},{"id":"https://openalex.org/C2779223914","wikidata":"https://www.wikidata.org/wiki/Q5997960","display_name":"Iliac fossa","level":2,"score":0.45559242367744446},{"id":"https://openalex.org/C2780696933","wikidata":"https://www.wikidata.org/wiki/Q183330","display_name":"Fossa","level":2,"score":0.4481085538864136},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.42531758546829224},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.4108280837535858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31444597244262695},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3125779628753662},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2990752160549164},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24553841352462769},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.23371678590774536}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003135","descriptor_name":"Common Bile Duct","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2267673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2267673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","raw_type":"Journal Article"},{"id":"mag:2394811827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2267673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075180453","https://openalex.org/W2414620628","https://openalex.org/W278753676","https://openalex.org/W2954428254","https://openalex.org/W2037000450","https://openalex.org/W2083341297","https://openalex.org/W357387985","https://openalex.org/W2011684592","https://openalex.org/W1600024857","https://openalex.org/W223633722"],"abstract_inverted_index":{"Introduction":[0],"of":[1,39,53,59,81,99,104,119,142,161,173],"'silent'":[2],"exocrine":[3,143],"atrophy":[4],"(and":[5],"endocrine":[6,145],"'enrichment')":[7],"in":[8,18,36,89,122],"pancreatic":[9,32],"grafts":[10,107],"following":[11],"ductular":[12,178],"blockade":[13],"may":[14],"have":[15],"a":[16],"role":[17],"human":[19],"diabetes":[20],"by":[21],"circumventing":[22],"currently":[23],"elusive":[24],"islet":[25],"isolation/purification":[26],"protocols.":[27],"To":[28],"explore":[29],"this":[30],"potential,":[31],"isografts":[33],"were":[34,87],"performed":[35,47],"12":[37],"pairs":[38],"inbred":[40],"Wistar":[41],"NIN":[42],"rats.":[43],"Donor":[44],"pancreatectomy":[45],"was":[46],"after":[48],"distal":[49],"clamping":[50],"and":[51,57,95,110,116,131,137,144,151,159,171],"canulation":[52],"common":[54],"bile":[55],"duct":[56],"injection":[58],"0.5":[60],"ml.":[61],"polyacrylamide":[62],"gel":[63],"(blocked":[64],"n":[65,72],"=":[66,73],"7)":[67],"or":[68],"normal":[69],"saline":[70],"(un-blocked":[71],"5)":[74],"respectively.":[75],"One":[76],"to":[77,90],"2":[78,91],"m.m.":[79],"fragments":[80],"the":[82,105,124,128,174],"resulting":[83],"mildly":[84],"distended":[85],"pancreases":[86],"transplanted":[88,106],"sites":[92,129,165],"(renal":[93],"capsule":[94],"iliac":[96,111],"fossa":[97,112],"subcutaneously)":[98],"cach":[100],"recipient.":[101],"Post-operative":[102],"biopsies":[103],"(unilateral":[108],"nephrectomy":[109],"biopsies)":[113],"revealed":[114],"macroscopic":[115],"microscopic":[117],"evidence":[118],"necrotizing":[120],"pancreatitis":[121],"both":[123,127],"groups":[125],"at":[126],"(histiocytic":[130],"giant":[132],"cell":[133],"infiltration,":[134],"fat":[135],"necrosis":[136],"focal":[138],"calcification":[139],"with":[140],"destruction":[141],"cells)":[146],"as":[147,149],"early":[148],"1":[150],"3":[152],"weeks.":[153],"Possible":[154],"detrimental":[155],"factors":[156],"include:":[157],"volume":[158],"pressure":[160],"ductal":[162],"injection,":[163],"graft":[164],"(confined":[166],"spaces),":[167],"post-operative":[168],"wound":[169],"infection":[170],"bio-compatibility":[172],"material":[175],"used":[176],"for":[177],"blockade.":[179]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}