{"id":"https://openalex.org/W2394792546","doi":null,"title":"[Sulfuric acid submicron aerosols induce morphological changes in the central airways in the guinea pig].","display_name":"[Sulfuric acid submicron aerosols induce morphological changes in the central airways in the guinea pig].","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2394792546","mag":"2394792546","pmid":"https://pubmed.ncbi.nlm.nih.gov/1753535"},"language":"ja","primary_location":{"id":"pmid:1753535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1753535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyobu Shikkan Gakkai zasshi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102806617","display_name":"Atsushi Nagai","orcid":"https://orcid.org/0000-0002-9280-8044","observed_orcids":["https://orcid.org/0000-0002-9280-8044"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Nagai","raw_affiliation_strings":["First Department of Medicine, Tokyo Women's Medical College. 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Tokyo Women's Medical College. 2","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089114723","display_name":"Kyoichi Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Sakamoto","raw_affiliation_strings":["First Department of Medicine, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078480750","display_name":"Takao Takizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Takizawa","raw_affiliation_strings":["First Department of Medicine, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Morinobu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Morinobu","raw_affiliation_strings":["Department of Hygiene and Public Health, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067548585","display_name":"Yuko Yamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yamano","raw_affiliation_strings":["Department of Hygiene and Public Health, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030334322","display_name":"Noriki Nagao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Nagao","raw_affiliation_strings":["Department of Hygiene and Public Health, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062162291","display_name":"Yoko Ishihara","orcid":"https://orcid.org/0000-0003-3269-0803","observed_orcids":["https://orcid.org/0000-0003-3269-0803"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Ishihara","raw_affiliation_strings":["Department of Hygiene and Public Health, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110029667","display_name":"Jun Kagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Kagawa","raw_affiliation_strings":["Department of Hygiene and Public Health, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210136522"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.25138217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"29","issue":"8","first_page":"993","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10075","display_name":"Atmospheric chemistry and aerosols","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1902","display_name":"Atmospheric Science"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfuric-acid-aerosol","display_name":"sulfuric acid aerosol","score":0.9169999957084656},{"id":"https://openalex.org/keywords/submicron-particles","display_name":"submicron particles","score":0.9580000042915344},{"id":"https://openalex.org/keywords/airway-injury","display_name":"airway injury","score":0.8790000081062317},{"id":"https://openalex.org/keywords/central-airways","display_name":"central airways","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cilia-loss","display_name":"cilia loss","score":0.7360000014305115},{"id":"https://openalex.org/keywords/epithelial-injury","display_name":"epithelial damage","score":0.9160000085830688},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6729999780654907},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5059999823570251},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2778199549","wikidata":"https://www.wikidata.org/wiki/Q4118","display_name":"Sulfuric acid","level":2,"score":0.8743288516998291},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.784076452255249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7569020986557007},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4934298098087311},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.45040756464004517},{"id":"https://openalex.org/C2911164631","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma attack","level":3,"score":0.44535285234451294},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34760719537734985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29971253871917725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28357386589050293},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27059975266456604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11865681409835815},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.07245159149169922}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013464","descriptor_name":"Sulfuric Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1753535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1753535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyobu Shikkan Gakkai zasshi","raw_type":"English Abstract"},{"id":"mag:2394792546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1753535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1728050100","https://openalex.org/W1973353475","https://openalex.org/W2004658321","https://openalex.org/W2018442333","https://openalex.org/W2088862863","https://openalex.org/W2339225148"],"related_works":["https://openalex.org/W58543514","https://openalex.org/W198859269","https://openalex.org/W2441932658","https://openalex.org/W2053210781","https://openalex.org/W149447448","https://openalex.org/W7096023619","https://openalex.org/W2473138111","https://openalex.org/W1995523774","https://openalex.org/W2076022778","https://openalex.org/W1970226539"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,6,67,73,76,96,104],"airway":[3],"injury":[4,60,77],"of":[5,49,64,75,89,106],"guinea":[7],"pig":[8],"exposed":[9,20],"to":[10,21,27],"sulfuric":[11,29,90],"acid":[12,30,50,91],"submicron":[13],"aerosols":[14,31],"(1":[15],"mg/m3).":[16],"The":[17],"animals":[18],"were":[19],"filtered":[22],"air":[23],"(sham":[24],"control)":[25],"or":[26],"submicrometer-sized":[28],"for":[32],"4":[33,40,47],"hr/day,":[34],"6":[35],"days/week,":[36],"with":[37,79],"sacrifices":[38],"after":[39],"hours,":[41],"3":[42],"days,":[43],"1,":[44],"2,":[45],"and":[46,53,72,99],"weeks":[48],"exposure.":[51],"Light":[52],"electron":[54],"microscopic":[55],"examinations":[56],"revealed":[57],"that":[58,86],"epithelial":[59],"such":[61],"as":[62],"disappearance":[63],"cilia":[65],"in":[66,95,103],"central":[68,97],"airways":[69,98],"was":[70],"observed":[71],"severity":[74],"increased":[78],"exposure":[80],"duration.":[81],"This":[82],"experimental":[83],"study":[84],"shows":[85],"submicrometer":[87],"particles":[88],"induces":[92],"significant":[93],"alterations":[94],"may":[100],"be":[101],"involved":[102],"incidence":[105],"asthma":[107],"attack.":[108]},"counts_by_year":[{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
