{"id":"https://openalex.org/W239477527","doi":"https://doi.org/10.21236/ada453097","title":"Effects of Ammonium Perchlorate Exposure in Pregnant Rats: A Morphometric Analysis of the Thyroid Gland of Rat Pups","display_name":"Effects of Ammonium Perchlorate Exposure in Pregnant Rats: A Morphometric Analysis of the Thyroid Gland of Rat Pups","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W239477527","doi":"https://doi.org/10.21236/ada453097","mag":"239477527"},"language":"en","primary_location":{"id":"doi:10.21236/ada453097","doi":"https://doi.org/10.21236/ada453097","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada453097","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Air Force","raw_type":"report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"William H. Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William H. Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009267295","display_name":"David R. Mattie","orcid":"https://orcid.org/0000-0003-3032-9280","observed_orcids":["https://orcid.org/0000-0003-3032-9280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Mattie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002844014","display_name":"Kathleen L. MacMahon","orcid":"https://orcid.org/0000-0003-0257-3630","observed_orcids":["https://orcid.org/0000-0003-0257-3630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen L. MacMahon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13563","display_name":"Chemical Analysis and Environmental Impact","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13563","display_name":"Chemical Analysis and Environmental Impact","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonium-perchlorate","display_name":"ammonium perchlorate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/perchlorate-toxicity","display_name":"perchlorate toxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/thyroid","display_name":"thyroid gland","score":0.6629999876022339},{"id":"https://openalex.org/keywords/thyroid-morphology","display_name":"thyroid morphology","score":0.6919999718666077},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.7480000257492065},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.6769999861717224},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5929999947547913},{"id":"https://openalex.org/keywords/reference-dose","display_name":"reference dose","score":0.8109999895095825},{"id":"https://openalex.org/keywords/groundwater-contamination","display_name":"groundwater contamination","score":0.7599999904632568},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.8310590982437134},{"id":"https://openalex.org/C2776704483","wikidata":"https://www.wikidata.org/wiki/Q410203","display_name":"Ammonium perchlorate","level":3,"score":0.796225905418396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5403099656105042},{"id":"https://openalex.org/C2780709120","wikidata":"https://www.wikidata.org/wiki/Q407189","display_name":"Perchlorate","level":3,"score":0.5391703844070435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4611208140850067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43701571226119995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2784993648529053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2403111755847931},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1313014030456543},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada453097","doi":"https://doi.org/10.21236/ada453097","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada453097","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Air Force","raw_type":"report"},{"id":"pmh:ADA453097","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA453097","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045850619","https://openalex.org/W2058352487","https://openalex.org/W4390191639","https://openalex.org/W2013650249","https://openalex.org/W2149514293","https://openalex.org/W2030251964","https://openalex.org/W2059848881","https://openalex.org/W1985038936","https://openalex.org/W4224239408","https://openalex.org/W2026008623"],"abstract_inverted_index":{"Characterization":[0],"of":[1,8,15,30,38,40,53,133,172,199],"potential":[2],"risks":[3],"posed":[4],"by":[5,11,27,120],"perchlorate":[6,55,80],"contamination":[7],"ground":[9],"water":[10],"the":[12,28,47,51,63,173,176,197],"partnered":[13],"efforts":[14],"industry":[16],"representative":[17],"and":[18,20,60,84,97,101,111,124,128,138,158,162,185],"federal":[19],"state":[21],"regulatory":[22],"agencies":[23],"has":[24],"been":[25],"hindered":[26],"paucity":[29],"reliable":[31],"toxicology":[32],"data.":[33],"Our":[34],"study,":[35],"a":[36,143,200,210],"byproduct":[37],"one":[39],"eight":[41],"new":[42],"studies":[43],"recommended":[44],"to":[45,86,169],"fill":[46],"data":[48,192],"gaps,":[49],"addresses":[50],"effect":[52],"ammonium":[54,79],"on":[56,204],"thyroid":[57],"gland":[58],"morphology":[59],"function":[61],"in":[62,103,146,156,165,209],"developing":[64],"fetus.":[65],"Female":[66],"rats":[67],"were":[68,93,118],"dosed":[69],"orally":[70],"with":[71,126,150],"10,":[72,160],"3,":[73,161],"1,":[74],"0.1,":[75],"or":[76],"0":[77],"mg/kg":[78,155,164],"daily":[81],"during":[82],"pregnancy":[83],"out":[85],"10":[87,109,112,154],"days":[88,99],"postpartum.":[89],"Thyroids":[90,171],"from":[91],"offspring":[92],"collected":[94],"at":[95,153,159],"5":[96],"81":[98],"postpartum":[100],"fixed":[102],"10%":[104],"buffered":[105],"formalin.":[106],"Randomly":[107],"selected":[108],"male":[110],"female":[113,139],"samples":[114],"per":[115],"dose":[116,183,202,207],"group":[117],"processed":[119],"routine":[121],"histologic":[122],"techniques":[123],"stained":[125],"hematoxylin":[127],"eosin":[129],"for":[130,187,196],"morphometric":[131],"assessment":[132],"follicular":[134,147],"lumen":[135,148],"areas.":[136],"Male":[137],"5-day-old":[140],"pups":[141],"displayed":[142],"dose-related":[144],"reduction":[145],"areas":[149],"significant":[151],"differences":[152,181],"females":[157],"0.1":[163],"males":[166],"when":[167],"compared":[168],"controls.":[170],"recovery":[174],"cohort,":[175],"81-day-old":[177],"rats,":[178],"demonstrated":[179],"no":[180],"between":[182],"groups":[184],"controls":[186],"either":[188],"sex.":[189],"The":[190],"above":[191],"will":[193],"contribute":[194],"information":[195],"generation":[198],"reference":[201],"based":[203],"relatively":[205],"low":[206],"levels":[208],"sensitive":[211],"subpopulation.":[212]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}