{"id":"https://openalex.org/W2394770824","doi":null,"title":"Can we influence fibrosis in Crohn's disease?","display_name":"Can we influence fibrosis in Crohn's disease?","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2394770824","mag":"2394770824","pmid":"https://pubmed.ncbi.nlm.nih.gov/11475134"},"language":"en","primary_location":{"id":"pmid:11475134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11475134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045465014","display_name":"Gert Van Assche","orcid":"https://orcid.org/0000-0003-0401-4664","observed_orcids":["https://orcid.org/0000-0003-0401-4664"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"G V Assche","raw_affiliation_strings":["Department of Gastroenterology, University Hospital Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University Hospital Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045465014"],"corresponding_institution_ids":["https://openalex.org/I2800231306"],"apc_list":null,"apc_paid":null,"fwci":1.1543,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81782918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64","issue":"2","first_page":"193","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intestinal-fibrosis","display_name":"intestinal fibrosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fibrostenosis","display_name":"fibrostenosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.9900000095367432},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"smooth muscle","score":0.7009999752044678},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9440000057220459},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9950000047683716},{"id":"https://openalex.org/keywords/restenosis-prevention","display_name":"restenosis prevention","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fibrosis-treatment","display_name":"fibrosis treatment","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8375422954559326},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6974549889564514},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.6943453550338745},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6184550523757935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5524767637252808},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5304616689682007},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4962201714515686},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4538026452064514},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43942829966545105},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4165571928024292},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40253981947898865},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3659365177154541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32902297377586365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3082978129386902},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2442883551120758},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21139469742774963}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007415","descriptor_name":"Intestinal Obstruction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007415","descriptor_name":"Intestinal Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007415","descriptor_name":"Intestinal Obstruction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11475134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11475134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},{"id":"mag:2394770824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11475134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2922895641","https://openalex.org/W2124929831","https://openalex.org/W4210762283","https://openalex.org/W4206706982","https://openalex.org/W1997413662","https://openalex.org/W4400914366","https://openalex.org/W2730947161","https://openalex.org/W2315121194","https://openalex.org/W193090981","https://openalex.org/W4404553467"],"abstract_inverted_index":{"Despite":[0],"recent":[1],"advances":[2],"in":[3,33,52,60,87,131,168,174,191],"the":[4,17,29,49,82,88,94,132,157,169,192],"therapy":[5],"of":[6,16,21,28,48,96,106,139,160,171,194],"active":[7],"Crohn's":[8,195],"disease":[9,196],"(CD)":[10],"fibrostenosis":[11],"remains":[12],"a":[13],"challenging":[14],"complication":[15],"disease.":[18],"Transmural":[19],"inflammation":[20,108],"CD":[22,53],"is":[23,148],"associated":[24],"with":[25,109,156],"phenotypic":[26,158],"switch":[27,159],"mesenchymal":[30,129,161],"cells":[31,47,51,162],"resulting":[32],"proliferation":[34,130],"and":[35,41,70,73,146,176],"collagen":[36],"deposition.":[37],"Both":[38],"resident":[39],"myofibroblasts":[40],"smooth":[42],"muscle":[43],"are":[44,185],"candidate":[45],"progenitor":[46],"fibrogenic":[50],"stenoses.":[54],"The":[55,136],"principal":[56],"growth":[57],"factors":[58],"involved":[59],"intestinal":[61,134],"fibrosis":[62,86,111],"have":[63,112],"not":[64],"been":[65,91,113],"identified":[66],"although":[67],"TGF-beta":[68],"1":[69],"2,":[71],"PDGF":[72],"IL-1":[74],"may":[75,126,163],"be":[76],"involved.":[77],"Research":[78],"aimed":[79],"at":[80],"elucidating":[81],"basic":[83],"mechanisms":[84],"underlying":[85],"gut":[89],"has":[90,118],"hindered":[92],"by":[93],"lack":[95],"an":[97,149],"adequate":[98],"animal":[99,177],"model.":[100],"Recently,":[101],"however,":[102],"new":[103,165],"rodent":[104],"models":[105],"chronic":[107],"distinct":[110],"described.":[114],"Cell":[115],"culture":[116],"research":[117],"provided":[119],"more":[120],"information":[121],"about":[122],"possible":[123],"pathways":[124],"that":[125],"limit":[127],"uncontrolled":[128],"inflamed":[133],"wall.":[135],"modulator":[137],"role":[138],"neurotransmitters":[140],"such":[141],"as":[142,179,181],"VIP,":[143],"nitric":[144],"oxide":[145],"prostaglandines":[147],"important":[150],"target":[151],"for":[152],"therapeutic":[153,166],"intervention.":[154],"Interfering":[155],"offer":[164],"perspectives":[167],"prevention":[170,183,193],"fibrostenosis.":[172,197],"Further":[173],"vitro":[175],"studies":[178,184],"well":[180],"restenosis":[182],"needed":[186],"to":[187],"develop":[188],"pharmacological":[189],"tools":[190]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
