{"id":"https://openalex.org/W2394738164","doi":null,"title":"[Two cases of non-small cell lung cancer which developed central nervous system metastases during gefitinib treatment, improving after changing to erlotinib treatment].","display_name":"[Two cases of non-small cell lung cancer which developed central nervous system metastases during gefitinib treatment, improving after changing to erlotinib treatment].","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2394738164","mag":"2394738164","pmid":"https://pubmed.ncbi.nlm.nih.gov/20184251"},"language":"ja","primary_location":{"id":"pmid:20184251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20184251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071084888","display_name":"Kei Kunimasa","orcid":"https://orcid.org/0000-0002-5241-3486","observed_orcids":["https://orcid.org/0000-0002-5241-3486"]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Kunimasa","raw_affiliation_strings":["Department of Respiratory Medicine, Kurashiki Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Kurashiki Central Hospital","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034733511","display_name":"Hiroshige Yoshioka","orcid":"https://orcid.org/0000-0001-7724-0481","observed_orcids":["https://orcid.org/0000-0001-7724-0481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshige Yoshioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080717730","display_name":"Masahiro Iwasaku","orcid":"https://orcid.org/0000-0001-7269-5129","observed_orcids":["https://orcid.org/0000-0001-7269-5129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiro Iwasaku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011349417","display_name":"Akihiro Nishiyama","orcid":"https://orcid.org/0000-0002-4805-9787","observed_orcids":["https://orcid.org/0000-0002-4805-9787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiro Nishiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007840193","display_name":"Satoshi Ubukata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Ubukata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091096026","display_name":"Tadashi Ishida","orcid":"https://orcid.org/0000-0001-9628-9125","observed_orcids":["https://orcid.org/0000-0001-9628-9125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadashi Ishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4969,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73878535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"48","issue":"2","first_page":"166","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/central-nervous-system-metastases","display_name":"central nervous system metastasis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8360000252723694},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":1.0},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/third-line-therapy","display_name":"third-line therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-drug-concentration","display_name":"cerebrospinal fluid drug concentration","score":0.7879999876022339},{"id":"https://openalex.org/keywords/comparative-efficacy","display_name":"drug efficacy comparison","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.981075644493103},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9687527418136597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9052676558494568},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7050541639328003},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5404354929924011},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5292987823486328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5158988237380981},{"id":"https://openalex.org/C3017976582","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"First line treatment","level":3,"score":0.42055219411849976},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.36338740587234497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30286288261413574},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.25057506561279297}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20184251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20184251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993061513","https://openalex.org/W2055886672","https://openalex.org/W2022086732","https://openalex.org/W2938495237","https://openalex.org/W2768219214","https://openalex.org/W2396986876","https://openalex.org/W2405489781","https://openalex.org/W2082148749","https://openalex.org/W2604383642","https://openalex.org/W2589940128"],"abstract_inverted_index":{"We":[0],"report":[1],"two":[2],"cases":[3],"of":[4,81],"central":[5,119],"nervous":[6,120],"system":[7,121],"metastases":[8,62],"from":[9],"non-small":[10],"cell":[11],"lung":[12,43],"cancer":[13],"in":[14,103,112,118],"patients":[15],"being":[16],"administered":[17],"gefitinib,":[18,96],"which":[19],"improved":[20,48],"after":[21,40],"changing":[22,50,69],"treatment":[23,37,51,65,71],"to":[24,52,72],"erlotinib.":[25,53],"Case":[26,54],"1:":[27],"A":[28,56],"57-year-old":[29],"man":[30],"developed":[31,59],"carcinomatous":[32],"meningitis":[33],"while":[34],"receiving":[35],"third-line":[36,64],"with":[38,66],"gefitinib":[39,115],"surgery":[41],"for":[42],"cancer.":[44],"His":[45],"symptoms":[46],"markedly":[47],"upon":[49],"2:":[55],"54-year-old":[57],"woman":[58],"multiple":[60],"brain":[61,82],"during":[63],"gefitinib.":[67],"After":[68],"her":[70],"erlotinib,":[73],"enhanced":[74],"head":[75],"MRI":[76],"showed":[77,91],"that":[78],"the":[79,87,110],"size":[80],"lesions":[83],"had":[84],"decreased.":[85],"At":[86],"recommended":[88],"dosage,":[89],"erlotinib":[90,117],"higher":[92,102],"blood":[93],"concentrations":[94],"than":[95],"and":[97,116],"may":[98,108],"also":[99],"have":[100],"been":[101],"cerebral":[104],"spinal":[105],"fluid.":[106],"This":[107],"explain":[109],"difference":[111],"efficacy":[113],"between":[114],"metastases.":[122]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
