{"id":"https://openalex.org/W2394722790","doi":null,"title":"Multiple forms of cytochrome P-450 from kidney cortex microsomes of rabbits treated with phenobarbital.","display_name":"Multiple forms of cytochrome P-450 from kidney cortex microsomes of rabbits treated with phenobarbital.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2394722790","mag":"2394722790","pmid":"https://pubmed.ncbi.nlm.nih.gov/6433923"},"language":"en","primary_location":{"id":"pmid:6433923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6433923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry international","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083134882","display_name":"Kiyokazu Ogita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ogita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043617225","display_name":"Emi Kusunose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Kusunose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004365170","display_name":"Syunsuke Yamamoto","orcid":"https://orcid.org/0000-0002-0257-1216","observed_orcids":["https://orcid.org/0000-0002-0257-1216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yamamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575542","display_name":"K Ichihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ichihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084109210","display_name":"Masahiko Kusunose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kusunose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5034,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77066356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"2","first_page":"191","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9459999799728394},{"id":"https://openalex.org/keywords/aminopyrine","display_name":"aminopyrine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/7-ethoxycoumarin","display_name":"7-ethoxycoumarin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p-nitroanisole","display_name":"p-nitroanisole","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2777606763","wikidata":"https://www.wikidata.org/wiki/Q3322838","display_name":"Benzphetamine","level":4,"score":0.7829246520996094},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7038743495941162},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6534543633460999},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6351258754730225},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.585591197013855},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.5538151860237122},{"id":"https://openalex.org/C2910561336","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Kidney cortex","level":3,"score":0.5280086398124695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.521884024143219},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4129173457622528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2824029326438904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.232294499874115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1806565523147583}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003573","descriptor_name":"Cytochrome b Group","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009251","descriptor_name":"NADPH-Ferrihemoprotein Reductase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015786","descriptor_name":"Cytochromes b5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6433923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6433923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry international","raw_type":"Journal Article"},{"id":"mag:2394722790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6433923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1860577051","https://openalex.org/W2410570379","https://openalex.org/W2140721195","https://openalex.org/W2096763509","https://openalex.org/W1426833344","https://openalex.org/W1909277103","https://openalex.org/W2410631037","https://openalex.org/W2094948961","https://openalex.org/W2402315061","https://openalex.org/W2437057387"],"abstract_inverted_index":{"Two":[0],"distinct":[1],"forms":[2],"of":[3,21,32,48,57,77,138],"cytochrome":[4,90],"P-450":[5],"(P-450),":[6],"referred":[7],"to":[8,94],"as":[9,120],"P-450a":[10,26,130],"and":[11,15,34,52,55,79,107,124,131,140],"P-450b,":[12],"were":[13],"separated":[14],"purified":[16],"from":[17],"kidney":[18,145],"cortex":[19,146],"microsomes":[20],"rabbits":[22],"treated":[23],"with":[24],"phenobarbital.":[25],"had":[27,72],"a":[28,73],"monomeric":[29,74],"molecular":[30,75],"weight":[31,76],"53,000,":[33],"its":[35,80],"CO-reduced":[36,81],"difference":[37,82],"spectral":[38,83],"peak":[39,84],"was":[40,61,85,91],"at":[41,86,97,109],"450":[42],"nm.":[43,88],"It":[44,99,126],"catalyzed":[45],"the":[46,53,68,110,136],"omega-hydroxylation":[47],"prostaglandin":[49],"A1":[50],"(PGA1),":[51],"omega-":[54],"(omega-1)-hydroxylation":[56],"myristate,":[58],"but":[59],"it":[60],"inactive":[62],"toward":[63],"exogenous":[64,117,141],"compounds":[65,118],"tested.":[66],"On":[67],"other":[69],"hand,":[70],"P-450b":[71,114,132],"49,000,":[78],"451":[87],"This":[89],"not":[92],"able":[93],"hydroxylate":[95],"PGA1":[96,139],"all.":[98],"hydroxylated":[100],"myristate":[101],"much":[102],"more":[103],"slowly":[104],"than":[105],"P-450a,":[106,113],"preferentially":[108],"(omega-1)-position.":[111],"Unlike":[112],"efficiently":[115],"metabolized":[116],"such":[119],"benzphetamine,":[121],"aminopyrine,":[122],"7-ethoxycoumarin":[123],"p-nitroanisole.":[125],"is":[127],"suggested":[128],"that":[129],"are":[133],"specialized":[134],"for":[135],"metabolism":[137],"compounds,":[142],"respectively,":[143],"in":[144],"microsomes.":[147]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}