{"id":"https://openalex.org/W2394686291","doi":null,"title":"The management of anti-tuberculosis drug-induced hepatotoxicity.","display_name":"The management of anti-tuberculosis drug-induced hepatotoxicity.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2394686291","mag":"2394686291","pmid":"https://pubmed.ncbi.nlm.nih.gov/11263519"},"language":"en","primary_location":{"id":"pmid:11263519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11263519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043606554","display_name":"Kemal Tahao\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tahao\u011flu","raw_affiliation_strings":["S\u00fcreyyapa\u015fa Center for Chest Disease and Thoracic Surgery, Istanbul, Turkey. kemaltaha@hotmail.com","S\u00fcreyyapa\u015fa Center for Chest Disease and Thoracic Surgery, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00fcreyyapa\u015fa Center for Chest Disease and Thoracic Surgery, Istanbul, Turkey. kemaltaha@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"S\u00fcreyyapa\u015fa Center for Chest Disease and Thoracic Surgery, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111830133","display_name":"G Ata\u00e7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Ata\u00e7","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053950791","display_name":"T\u00fclin Sevim","orcid":"https://orcid.org/0000-0003-4989-8168","observed_orcids":["https://orcid.org/0000-0003-4989-8168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sevim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T T\u00e4r\u00fcn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T T\u00e4r\u00fcn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036971860","display_name":"\u00d6zlem Mo\u00e7in Yaz\u0131c\u0131o\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Yazicio\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031767624","display_name":"G\u00fclbanu Horzum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Horzum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065415566","display_name":"I Gemci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Gemci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074486496","display_name":"A Ongel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ongel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087422033","display_name":"Nil\u00fcfer Kapakl\u0131","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Kapakli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074935800","display_name":"Emine Aksoy","orcid":"https://orcid.org/0000-0002-5962-8332","observed_orcids":["https://orcid.org/0000-0002-5962-8332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Aksoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4726,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.80867759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"65","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8090000152587891},{"id":"https://openalex.org/keywords/retreatment-tuberculosis","display_name":"retreatment tuberculosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":0.9010000228881836},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/ethambutol","display_name":"ethambutol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/streptomycin","display_name":"streptomycin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.9826374053955078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9658765196800232},{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.9516626000404358},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.8670529127120972},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.7777241468429565},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.768628716468811},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7422360181808472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4797014892101288},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4703871011734009},{"id":"https://openalex.org/C2775843808","wikidata":"https://www.wikidata.org/wiki/Q192717","display_name":"Streptomycin","level":3,"score":0.42037487030029297},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3298163414001465},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1856878101825714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06518909335136414},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11263519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11263519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Clinical Trial"},{"id":"mag:2394686291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11263519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029597598","https://openalex.org/W2158075503","https://openalex.org/W2094286165","https://openalex.org/W2548672095","https://openalex.org/W2165859651","https://openalex.org/W7095639214","https://openalex.org/W7151952435","https://openalex.org/W2128087140","https://openalex.org/W2171320840","https://openalex.org/W2324678685"],"abstract_inverted_index":{"SETTING:":[0],"A":[1],"tuberculosis":[2,24,36,158],"ward":[3],"in":[4,23,43,74,91,99,106,154,161],"a":[5,28,52,165,178],"chest":[6],"disease":[7],"teaching":[8],"hospital.":[9],"OBJECTIVE:":[10],"To":[11],"compare":[12],"the":[13,66,71,83,92,115,132,140,155,162],"efficacy":[14],"of":[15,56,70,120,142,152,157,164,177],"two":[16],"different":[17],"retreatment":[18,134,156],"protocols":[19],"on":[20],"hepatotoxicity":[21,38,153,173],"recurrence":[22,119,150],"treatment.":[25,41],"DESIGN:":[26],"In":[27],"prospective,":[29],"randomised":[30],"study,":[31],"45":[32],"patients":[33,105,117,145],"with":[34,51,82,118],"new":[35],"developed":[37],"after":[39],"anti-tuberculosis":[40],"Patients":[42,73],"Group":[44,75,137],"I":[45,108],"(n":[46,77],"=":[47,78,112],"20)":[48],"were":[49,80,146],"retreated":[50,81],"drug":[53],"regimen":[54,85,167,179],"consisting":[55],"isoniazid,":[57],"rifampicin,":[58,87],"ethambutol":[59],"and":[60,68,89,102,109],"streptomycin":[61],"administered":[62],"by":[63],"gradually":[64],"increasing":[65],"number":[67],"dosage":[69],"drugs.":[72],"II":[76,110],"25)":[79],"same":[84,93,133],"(isoniazid,":[86],"pyrazinamide":[88],"ethambutol)":[90],"dosages":[94],"throughout.":[95],"RESULTS:":[96],"Hepatotoxicity":[97],"recurred":[98],"respectively":[100],"zero":[101],"six":[103,116],"(24%)":[104],"Groups":[107],"(P":[111],"0.021).":[113],"Of":[114],"hepatitis,":[121],"one":[122],"could":[123],"not":[124],"be":[125],"followed":[126],"up.":[127],"The":[128,149],"other":[129],"five":[130],"received":[131],"protocol":[135],"as":[136],"I.":[138],"By":[139],"end":[141],"retreatment,":[143],"all":[144],"cured.":[147],"CONCLUSION:":[148],"rate":[151],"is":[159],"higher":[160],"reintroduction":[163,176],"full-dose":[166],"including":[168],"pyrazinamide,":[169],"which":[170],"causes":[171],"more":[172],"than":[174],"gradual":[175],"without":[180],"pyrazinamide.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
