{"id":"https://openalex.org/W2394660465","doi":"https://doi.org/10.1080/00034983.1987.11812098","title":"Plasma concentrations and toxicity of chloroquine after slow intravenous infusion in patients with falciparum malaria","display_name":"Plasma concentrations and toxicity of chloroquine after slow intravenous infusion in patients with falciparum malaria","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2394660465","doi":"https://doi.org/10.1080/00034983.1987.11812098","mag":"2394660465","pmid":"https://pubmed.ncbi.nlm.nih.gov/3318731"},"language":"en","primary_location":{"id":"doi:10.1080/00034983.1987.11812098","doi":"https://doi.org/10.1080/00034983.1987.11812098","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00034983.1987.11812098","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061252066","display_name":"Geoffrey Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"other","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Edwards","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, U.K","Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, U.K. and Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, U.K","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, U.K. and Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, U.K","institution_ids":["https://openalex.org/I146655781","https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003918662","display_name":"Andrea Davies","orcid":"https://orcid.org/0000-0001-5445-8525","observed_orcids":["https://orcid.org/0000-0001-5445-8525"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. J. Davies","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, U.K","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113711736","display_name":"R E Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"other","lineage":["https://openalex.org/I194839184"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"R. E. Phillips","raw_affiliation_strings":["Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5AQ U.K. and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5AQ U.K. and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I194839184","https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107849101","display_name":"S. Looareesuwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"S. Looareesuwan","raw_affiliation_strings":["Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045836221","display_name":"Juntra Karbwang","orcid":"https://orcid.org/0000-0003-2107-7173","observed_orcids":["https://orcid.org/0000-0003-2107-7173"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"J. Karbwang","raw_affiliation_strings":["Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084217335","display_name":"Nicholas John White","orcid":"https://orcid.org/0000-0002-1897-1978","observed_orcids":["https://orcid.org/0000-0002-1897-1978","https://orcid.org/0000-0003-2309-1171","https://orcid.org/0000-0001-5038-8865"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"other","lineage":["https://openalex.org/I194839184"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210091134","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/00fdbgx35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210091134"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"N. J. White","raw_affiliation_strings":["Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K., Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, and Nuffield Department of Clinical Medicine, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K., Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, and Nuffield Department of Clinical Medicine, University of Oxford, U.K","institution_ids":["https://openalex.org/I194839184","https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210091134","https://openalex.org/I4405277806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109160704","display_name":"D A Warrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"other","lineage":["https://openalex.org/I194839184"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210091134","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/00fdbgx35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210091134"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"D. A. Warrell","raw_affiliation_strings":["Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K., Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, and Nuffield Department of Clinical Medicine, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA, U.K., Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, and Nuffield Department of Clinical Medicine, University of Oxford, U.K","institution_ids":["https://openalex.org/I194839184","https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210091134","https://openalex.org/I4405277806"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.711,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.89099143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"81","issue":"2","first_page":"79","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.8429999947547913},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.9900000095367432},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.9039999842643738},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.9570000171661377},{"id":"https://openalex.org/keywords/malaria-treatment","display_name":"malaria treatment","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.9372302293777466},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8272871971130371},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7719419002532959},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7001147270202637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6126333475112915},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.5063518285751343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4393761456012726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3511096239089966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28251564502716064},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2055613100528717}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00034983.1987.11812098","doi":"https://doi.org/10.1080/00034983.1987.11812098","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00034983.1987.11812098","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"},{"id":"pmid:3318731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3318731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of tropical medicine and parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W67841380","https://openalex.org/W580952738","https://openalex.org/W1818269711","https://openalex.org/W1964528848","https://openalex.org/W1973443840","https://openalex.org/W1980331499","https://openalex.org/W1987615154","https://openalex.org/W1998654809","https://openalex.org/W2009491078","https://openalex.org/W2019958206","https://openalex.org/W2038649469","https://openalex.org/W2045579882","https://openalex.org/W2055877540","https://openalex.org/W2060168550","https://openalex.org/W2069229064","https://openalex.org/W2079500426","https://openalex.org/W2086721048","https://openalex.org/W2126883684","https://openalex.org/W2237046202","https://openalex.org/W2306953861","https://openalex.org/W2343640722","https://openalex.org/W2347786798","https://openalex.org/W2424051795","https://openalex.org/W4234450170","https://openalex.org/W4242365880","https://openalex.org/W4244971233"],"related_works":["https://openalex.org/W2126883684","https://openalex.org/W2024569750","https://openalex.org/W1978308576","https://openalex.org/W1966806224","https://openalex.org/W2341818975","https://openalex.org/W2038649469","https://openalex.org/W2998317607","https://openalex.org/W2059974010","https://openalex.org/W67841380","https://openalex.org/W1977017089"],"abstract_inverted_index":{"Five":[0],"male":[1],"patients":[2],"with":[3,13,107],"acute":[4],"Plasmodium":[5,8],"falciparum":[6,76],"or":[7],"vivax":[9],"infections":[10],"were":[11,30,42,78,92],"infused":[12],"chloroquine":[14,25,40,64],"diphosphate":[15,26],"(15":[16],"mg":[17,28],"kg-1)":[18,29],"over":[19],"four":[20,46,81],"hours.":[21,38],"Further":[22,86],"does":[23],"of":[24,73,83],"(5":[27],"given":[31],"at":[32],"12,":[33],"24,":[34],"36":[35],"and":[36,45,51,62],"60":[37],"Plasma":[39],"concentrations":[41,65,90],"determined":[43],"before":[44],"hours":[47,82],"after":[48],"each":[49],"dose":[50],"then":[52],"daily":[53],"until":[54],"discharge.":[55],"No":[56],"serious":[57],"cardiovascular":[58],"toxicity":[59],"was":[60],"observed,":[61],"plasma":[63,89],"exceeding":[66],"the":[67,95,104],"putative":[68,96],"minimum":[69],"inhibitory":[70],"concentration":[71],"(MIC)":[72],"sensitive":[74],"P.":[75],"strains":[77],"reached":[79],"within":[80],"starting":[84],"treatment.":[85],"doses":[87],"produced":[88],"which":[91],"sustained":[93],"above":[94],"MIC,":[97],"but":[98],"showed":[99],"no":[100],"rapid":[101],"increase":[102],"into":[103],"range":[105],"associated":[106],"toxicity.":[108]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
