{"id":"https://openalex.org/W2394636349","doi":null,"title":"Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.","display_name":"Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2394636349","mag":"2394636349","pmid":"https://pubmed.ncbi.nlm.nih.gov/2113597"},"language":"en","primary_location":{"id":"pmid:2113597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2113597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004166000","display_name":"Fabrizio Tagliavini","orcid":"https://orcid.org/0000-0003-1039-7315","observed_orcids":["https://orcid.org/0000-0003-1039-7315"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Tagliavini","raw_affiliation_strings":["Department of Pathology, New York University, Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University, Medical Center, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081547926","display_name":"Jorge A. Ghiso","orcid":"https://orcid.org/0000-0002-0870-0437","observed_orcids":["https://orcid.org/0000-0002-0870-0437"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Ghiso","raw_affiliation_strings":["New York University<sup>**</sup>"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University<sup>**</sup>","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036874983","display_name":"Willem Frederik Timmers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W F Timmers","raw_affiliation_strings":["New York University<sup>**</sup>"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University<sup>**</sup>","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025292977","display_name":"Giorgio Giaccone","orcid":"https://orcid.org/0000-0002-4803-0802","observed_orcids":["https://orcid.org/0000-0002-4803-0802"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Giaccone","raw_affiliation_strings":["Fondazione IRCCS Istituto Neurologico C. Besta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS Istituto Neurologico C. Besta","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040498388","display_name":"Orso Bugiani","orcid":"https://orcid.org/0000-0002-0999-4756","observed_orcids":["https://orcid.org/0000-0002-0999-4756"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Bugiani","raw_affiliation_strings":["New York University<sup>**</sup>"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University<sup>**</sup>","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041419276","display_name":"Blas Frangione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Frangione","raw_affiliation_strings":["New York University<sup>**</sup>"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University<sup>**</sup>","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.207,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.97905801,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"6","first_page":"761","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cerebral-amyloid-angiopathy","display_name":"cerebral amyloid angiopathy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type","display_name":"hereditary cerebral hemorrhage with amyloidosis-Dutch type","score":0.9039999842643738},{"id":"https://openalex.org/keywords/leptomeningeal-vessels","display_name":"leptomeningeal vessels","score":0.7490000128746033},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8389999866485596},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.8519999980926514},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.609000027179718},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.7294416427612305},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6595070958137512},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.6187439560890198},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5775784254074097},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5485367774963379},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.5331795811653137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5306868553161621},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.5285462737083435},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.49288225173950195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3334975242614746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32323241233825684},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18527787923812866}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2113597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2113597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},{"id":"mag:2394636349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2113597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3539107380","display_name":"CELL/PROTEIN INTERACTIONS IN CONNECTIVE TISSUE DISEASES","funder_award_id":"P01AR001431","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7046550140","https://openalex.org/W1866663684","https://openalex.org/W291256045","https://openalex.org/W1980580004","https://openalex.org/W1978134798","https://openalex.org/W1985348492","https://openalex.org/W1996155206","https://openalex.org/W1968912921","https://openalex.org/W2031654879","https://openalex.org/W1997103682"],"abstract_inverted_index":{"Polyclonal":[0],"antibodies":[1],"to":[2,6,26,106],"synthetic":[3],"peptides":[4],"homologous":[5],"amino":[7],"acid":[8],"residues":[9],"45-62,":[10],"597-624,":[11],"and":[12,34,39,46,64,76,90,121,129,132,179,190],"676-695":[13],"of":[14,18,30,32,61,85,88,99,104,112,149,177,183],"the":[15,28,35,91,137,171,181],"predicted":[16],"sequence":[17],"Alzheimer's":[19,43],"amyloid":[20,40,133,161],"precursor":[21],"protein":[22,41],"(APP)":[23],"were":[24,80],"used":[25],"investigate":[27],"site":[29],"origin":[31],"APP,":[33],"relationship":[36],"between":[37],"APP":[38,93,115,131,141,178,184],"in":[42,119,136,145,152,159,163,188,195],"disease":[44],"(AD)":[45],"hereditary":[47],"cerebral":[48],"hemorrhage":[49],"with":[50,70,74,101,127,147,165],"amyloidosis,":[51],"Dutch":[52],"type":[53],"(HCHWA-D).":[54],"Cortical":[55],"sections":[56,111],"as":[57,59,96],"well":[58],"homogenates":[60],"isolated":[62],"leptomeningeal":[63,120],"cortical":[65,110,122],"microvessels":[66],"from":[67],"three":[68],"patients":[69,73,89,126,164],"AD,":[71],"two":[72,77],"HCHWA-D,":[75,130],"nondemented":[78],"controls":[79],"probed.":[81],"In":[82,109,125],"vessel":[83,123],"extracts":[84],"both":[86],"groups":[87],"controls,":[92],"was":[94,117,143,156],"detected":[95],"a":[97,175],"set":[98],"proteins":[100],"electrophoretic":[102],"mobility":[103],"105":[105],"135":[107],"kilodaltons.":[108],"all":[113],"subjects,":[114],"immunoreactivity":[116,142],"found":[118,144],"walls.":[124],"AD":[128,153,189],"fibrils":[134,187],"coexisted":[135],"same":[138],"vessels.":[139],"Moreover,":[140],"association":[146],"50%":[148],"senile":[150],"plaques":[151],"brains,":[154],"but":[155],"not":[157],"evidenced":[158],"parenchymal":[160],"deposits":[162],"HCHWA-D.":[166],"These":[167],"data":[168],"suggest":[169],"that":[170,180],"vascular":[172],"system":[173],"is":[174],"source":[176],"processing":[182],"into":[185],"insoluble":[186],"HCHWA-D":[191],"may":[192],"take":[193],"place":[194],"situ.":[196]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
