{"id":"https://openalex.org/W2394625623","doi":null,"title":"Comparative study of symptoms and neuroendocrine-immune network mediator levels between rheumatoid arthritis patients and healthy subjects.","display_name":"Comparative study of symptoms and neuroendocrine-immune network mediator levels between rheumatoid arthritis patients and healthy subjects.","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2394625623","mag":"2394625623","pmid":"https://pubmed.ncbi.nlm.nih.gov/11072598"},"language":"en","primary_location":{"id":"pmid:11072598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11072598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077189588","display_name":"E Mukai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Mukai","raw_affiliation_strings":["Department of Joint Disease and Rheumatism, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Disease and Rheumatism, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111742299","display_name":"Mikio NAGASHIMA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nagashima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001496903","display_name":"D Hirano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Hirano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108194264","display_name":"S Yoshino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yoshino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3127,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80418574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"5","first_page":"585","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.07829999923706055,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neuroendocrine-immune-network","display_name":"neuroendocrine-immune network","score":0.9800000190734863},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.921999990940094},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cd57","display_name":"CD57","score":0.8370000123977661},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.675000011920929},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mood","display_name":"mood","score":0.8569999933242798},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9001715183258057},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.694392740726471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6818314790725708},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.564663290977478},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5411893129348755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5384831428527832},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5189002156257629},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.45080631971359253},{"id":"https://openalex.org/C38042653","wikidata":"https://www.wikidata.org/wiki/Q1500332","display_name":"Psychoneuroimmunology","level":3,"score":0.43008914589881897},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.4117429554462433},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30315089225769043},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.12750503420829773}],"mesh":[{"descriptor_ui":"D000339","descriptor_name":"Affect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006306","descriptor_name":"Health Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11072598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11072598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2394625623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11072598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064613672","https://openalex.org/W2159244636","https://openalex.org/W2002954143","https://openalex.org/W2086036770","https://openalex.org/W1919458374","https://openalex.org/W2349933377","https://openalex.org/W2089583674","https://openalex.org/W3084786599","https://openalex.org/W2281842187","https://openalex.org/W2753902959"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1,198,277],"order":[2],"to":[3,36,85,125,271,291],"understand":[4],"the":[5,8,12,30,38,79,87,116,139,156,168,173,177,180,195,207,212,218,222,229,231,233,241,245,253,257,264,269,272,280],"disturbances":[6],"in":[7,20,29,43,49,78,138,167,172,240,248,256,294],"neurophysiological,":[9],"endocrine":[10],"(including":[11],"hypothalamic-pituitary-adrenal":[13,281],"axis),":[14],"and":[15,19,24,48,76,95,104,115,128,150,161,188,211,216,221,237,286],"immune":[16],"systems":[17],"objectively":[18],"detail,":[21],"we":[22],"measured":[23,94,132,254],"compared":[25,96],"various":[26],"test":[27],"items":[28,255],"peripheral":[31,80,242,258],"blood":[32,259],"which":[33,82],"were":[34,93,123,131,153,165,190,260],"considered":[35,84],"reflect":[37,86],"state":[39],"of":[40,55,89,146,158,183,252],"these":[41],"systems,":[42],"patients":[44,99,200,279],"with":[45,100,263],"rheumatoid":[46,101],"arthritis":[47,102],"control":[50,107,174],"subjects.":[51,108,175],"METHODS:":[52],"The":[53,109,143,226],"levels":[54,145,157,182],"beta-endorphin,":[56],"methionine-enkephalin,":[57],"epinephrin,":[58,185],"norepinephrin":[59],"(NE),":[60],"dopamine,":[61,148],"corticotropin":[62],"releasing":[63],"factor":[64],"(CRF),":[65],"adrenocoricotropic":[66],"hormone":[67],"(ACTH),":[68],"cortisol,":[69],"CD4/CD8":[70,151],"ratio,":[71],"CD57,":[72],"NK":[73,162,234],"cell":[74,163,235],"activity":[75,88,164,236],"IL-6":[77,149,224,238],"blood,":[81],"are":[83],"this":[90,287],"neuroendocrine-immune":[91],"network,":[92],"between":[97,194,206,217],"49":[98],"(RA)":[103],"54":[105],"healthy":[106,249],"face":[110,208,265],"scale":[111,137,209,266],"(to":[112],"measure":[113],"mood)":[114],"Cornell":[117],"medical":[118],"index":[119],"(CMI)":[120],"health":[121,274],"questionnaire":[122],"administered":[124],"both":[126],"groups,":[127],"pain":[129,219],"scores":[130],"using":[133],"a":[134,201,292],"visual":[135],"analog":[136],"RA":[140,169,199,278],"group.":[141],"RESULTS:":[142],"serum":[144,181,213,223],"NE,":[147],"ratio":[152],"higher,":[154],"whereas":[155],"beta-endorphine,":[159],"ACTH":[160],"lower":[166],"subjects":[170],"than":[171],"On":[176,244],"other":[178,246],"hand,":[179,247],"Met-enk,":[184],"CRF,":[186],"cortisol":[187,214],"CD57":[189],"not":[191],"significantly":[192,261],"different":[193],"two":[196],"groups.":[197],"positive":[202],"correlation":[203],"was":[204],"observed":[205],"score":[210,220],"level":[215],"level.":[225],"more":[227],"severe":[228],"pain,":[230],"higher":[232],"concentrations":[239],"blood.":[243],"females":[250],"none":[251],"correlated":[262,290],"results":[267],"or":[268],"responses":[270],"CMI":[273],"questionnaire.":[275],"CONCLUSION:":[276],"(HPA)":[282],"axis":[283],"is":[284,289],"altered":[285],"condition":[288],"deterioration":[293],"symptoms.":[295]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
