{"id":"https://openalex.org/W2394534026","doi":null,"title":"[Effects on myointimal proliferation of an antisense oligonucleotide directed against c-myb: specificity of action and consequences on vasoreactivity].","display_name":"[Effects on myointimal proliferation of an antisense oligonucleotide directed against c-myb: specificity of action and consequences on vasoreactivity].","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2394534026","mag":"2394534026","pmid":"https://pubmed.ncbi.nlm.nih.gov/9501552"},"language":"fr","primary_location":{"id":"pmid:9501552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9501552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirurgie; memoires de l'Academie de chirurgie","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083875385","display_name":"Yves Castier","orcid":"https://orcid.org/0009-0007-0170-1668","observed_orcids":["https://orcid.org/0009-0007-0170-1668"]},"institutions":[{"id":"https://openalex.org/I4210166329","display_name":"H\u00f4pital Broussais","ror":"https://ror.org/05h8pvh61","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y Castier","raw_affiliation_strings":["H\u00f4pital Broussais, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Broussais, Paris","institution_ids":["https://openalex.org/I4210166329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111110814","display_name":"E. Chemla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Chemla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055690147","display_name":"Catherine Chardigny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Chardigny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032276342","display_name":"J Nierat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Nierat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001367243","display_name":"D Eudes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Eudes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082827231","display_name":"Vasseur Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Vasseur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028555797","display_name":"Patrick Bruneval","orcid":"https://orcid.org/0000-0002-2350-2914","observed_orcids":["https://orcid.org/0000-0002-2350-2914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Bruneval","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078956589","display_name":"Alain Carpentier","orcid":"https://orcid.org/0000-0003-2926-0060","observed_orcids":["https://orcid.org/0000-0003-2926-0060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Carpentier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113697298","display_name":"Jean\u2010No\u00ebl Fabiani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J N Fabiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25853202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"4","first_page":"260","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.26489999890327454,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1462000012397766,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8820000290870667},{"id":"https://openalex.org/keywords/c-myb","display_name":"MYB","score":0.984000027179718},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/abdominal-aorta","display_name":"abdominal aorta","score":0.8339999914169312},{"id":"https://openalex.org/keywords/vasoreactivity","display_name":"vasoreactivity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/acetylcholine-response","display_name":"acetylcholine response","score":0.7940000295639038},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6124993562698364},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5755894184112549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5311701893806458},{"id":"https://openalex.org/C62794011","wikidata":"https://www.wikidata.org/wiki/Q18029694","display_name":"MYB","level":4,"score":0.5070559978485107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40830695629119873},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39973339438438416},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3894478976726532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2883340120315552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2714206576347351},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15582367777824402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12437108159065247}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9501552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9501552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirurgie; memoires de l'Academie de chirurgie","raw_type":"English Abstract"},{"id":"mag:2394534026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9501552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2174300504","https://openalex.org/W2415387360","https://openalex.org/W2078769477","https://openalex.org/W2049597118","https://openalex.org/W2461398443","https://openalex.org/W2040216156","https://openalex.org/W2034487226","https://openalex.org/W1977135493","https://openalex.org/W2146354013","https://openalex.org/W2031979289"],"abstract_inverted_index":{"Several":[0],"reports":[1],"have":[2],"shown":[3],"that":[4],"an":[5,79,157],"antisense":[6,75,90,229],"oligonucleotide":[7],"directed":[8,76],"against":[9,77],"c-myb":[10,33,45,231],"(AS":[11],"18)":[12],"inhibits":[13,251],"the":[14,28,57,68,98,103,110,123,151,165,172,180,191,238,245,263],"proliferation":[15],"of":[16,22,30,49,56,67,109,118,133,139,171,190,202,224,226,230,240],"smooth":[17],"muscle":[18],"cell.":[19],"The":[20,160,206,222],"aims":[21],"this":[23,249,259],"study":[24,208],"were":[25,51,114,120,163,174],"to":[26,36,195,237],"confirm":[27],"specificity":[29],"a":[31,44,87],"new":[32],"antisens":[34],"and":[35,105,112,137,154,167,182,215,220,254],"evaluate":[37],"changes":[38],"in":[39,156,179,186,197,244,258],"vasoreactivity":[40],"following":[41,69,161],"treatment":[42],"with":[43,248],"antisense.":[46],"Five":[47],"groups":[48,117,213],"rats":[50,119],"constituted.":[52],"All":[53],"underwent":[54],"desendothelialisation":[55,128,130],"abdominal":[58],"aorta.":[59,99],"A":[60,214],"solution":[61],"containing":[62,83],"pluronic":[63],"gel,":[64],"or":[65,217],"one":[66],"oligonucleotides:":[70],"AS":[71,134,140,183,227],"18,":[72],"15":[73,88],"mere":[74,89],"c-myb,":[78],"aleatory":[80],"4G":[81,181],"sequence":[82,250],"4":[84,241],"consecutive":[85,242],"guanosines,":[86],"mismatch":[91],"(n":[92],"=":[93],"11),":[94],"was":[95,148],"applied":[96],"around":[97],"After":[100],"21":[101],"days,":[102],"thickness":[104,166],"mean":[106],"surface":[107,169],"areas":[108,170],"media":[111],"intima":[113,173],"calculated.":[115],"Four":[116],"constituted":[121],"for":[122],"reactivity":[124],"study:":[125],"control":[126],"(A),":[127],"(B),":[129],"+":[131],"application":[132,138],"18":[135,141,184,228],"(C),":[136],"alone":[142],"(D).":[143],"One":[144],"ring":[145],"per":[146],"aorta":[147],"sampled":[149],"at":[150],"21st":[152],"day":[153],"analysed":[155],"organ":[158],"chamber.":[159],"results":[162],"obtained:":[164],"average":[168],"smaller":[175],"(p":[176],"<":[177],"0.05)":[178],"groups;":[185],"group":[187,198],"B,":[188],"none":[189],"8":[192,203],"segments":[193,204],"responded":[194],"acetylcholine;":[196],"C,":[199],"6":[200],"out":[201],"responded.":[205],"contraction":[207],"showed":[209],"no":[210],"difference":[211],"between":[212,218],"D":[216],"B":[219],"C.":[221],"mode":[223],"action":[225],"is":[232],"non":[233],"specific":[234],"but":[235],"due":[236],"presence":[239],"guanosines":[243],"oligonucleotide.":[246],"Oligonucleotide":[247],"myo-intimal":[252],"hyperplasia":[253],"improves":[255],"endothelium-dependent":[256],"relaxation":[257],"model":[260],"without":[261],"affecting":[262],"contraction.":[264]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}