{"id":"https://openalex.org/W2394526285","doi":null,"title":"Treatment and prevention of enteric infections with toxin-binding probiotics.","display_name":"Treatment and prevention of enteric infections with toxin-binding probiotics.","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2394526285","mag":"2394526285","pmid":"https://pubmed.ncbi.nlm.nih.gov/17234126"},"language":"en","primary_location":{"id":"pmid:17234126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17234126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038494526","display_name":"Adrienne W. Paton","orcid":"https://orcid.org/0000-0002-2996-5733","observed_orcids":["https://orcid.org/0000-0002-2996-5733"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrienne W Paton","raw_affiliation_strings":["School of Molecular and Biomedical Science, University of Adelaide, S.A., 5005, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Biomedical Science, University of Adelaide, S.A., 5005, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023033615","display_name":"Renato Morona","orcid":"https://orcid.org/0000-0001-7009-7440","observed_orcids":["https://orcid.org/0000-0001-7009-7440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renato Morona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055597053","display_name":"James C. Paton","orcid":"https://orcid.org/0000-0001-9807-5278","observed_orcids":["https://orcid.org/0000-0001-9807-5278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C Paton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49913924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"31","first_page":"35","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gastrointestinal-infections","display_name":"gastrointestinal infections","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bacterial-toxins","display_name":"bacterial toxins","score":0.6970000267028809},{"id":"https://openalex.org/keywords/toxin-receptor","display_name":"toxin receptor","score":0.6840000152587891},{"id":"https://openalex.org/keywords/live-bacteria","display_name":"live bacteria","score":0.4259999990463257},{"id":"https://openalex.org/keywords/dead-bacteria","display_name":"dead bacteria","score":0.7519999742507935},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7739999890327454},{"id":"https://openalex.org/keywords/molecular-engineering","display_name":"molecular engineering","score":0.45899999141693115},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.6819999814033508},{"id":"https://openalex.org/keywords/infection-treatment","display_name":"infection treatment","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7183501720428467},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.7023779153823853},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6707538366317749},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.6261866688728333},{"id":"https://openalex.org/C2910153003","wikidata":"https://www.wikidata.org/wiki/Q5380200","display_name":"Enteric bacteria","level":4,"score":0.6260551810264587},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.540256917476654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4627971649169922},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.44495195150375366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3350852131843567},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.21165841817855835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0755932629108429},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05826231837272644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17234126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17234126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/34815","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/34815","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.discoverymedicine.com/ViewAbstract.php?rec=10409214446231373311193","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065620018","https://openalex.org/W2479039839","https://openalex.org/W4206177584","https://openalex.org/W2125839652","https://openalex.org/W4385152298","https://openalex.org/W3158221928","https://openalex.org/W4405925480","https://openalex.org/W7036022260","https://openalex.org/W1147765804","https://openalex.org/W2059964548"],"abstract_inverted_index":{"Nearly":[0],"all":[1],"antibiotics":[2],"aim":[3],"at":[4],"killing":[5],"the":[6,43,60],"bacteria,":[7],"which":[8],"eventually":[9],"develop":[10],"antibiotic":[11],"resistance":[12],"under":[13],"\"survival":[14],"pressure.\"":[15],"The":[16],"pathology":[17],"exerted":[18],"by":[19],"many":[20],"pathologic":[21],"bacteria":[22,31],"is":[23],"through":[24],"secreting":[25],"toxins.":[26],"Probiotics,":[27],"either":[28],"harmless":[29],"live":[30],"or":[32,58],"dead":[33],"ones,":[34],"can":[35],"be":[36],"molecularly":[37],"engineered":[38],"to":[39,52],"express":[40],"receptors":[41],"for":[42],"toxins":[44],"and":[45,47],"absorb":[46],"eliminate":[48],"them":[49],"from":[50],"binding":[51],"their":[53],"natural":[54],"receptors,":[55],"thus":[56],"reducing":[57],"eliminating":[59],"pathological":[61],"impact":[62],"of":[63],"bacterial":[64],"infection.":[65]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}