{"id":"https://openalex.org/W2394096037","doi":null,"title":"Studies on apoptosis in human retinoblastoma","display_name":"Studies on apoptosis in human retinoblastoma","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2394096037","mag":"2394096037"},"language":"en","primary_location":{"id":"mag:2394096037","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XKJZ200004004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764888772","display_name":"Yanke xinjinzhan","issn_l":"1003-5141","issn":["1003-5141"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323850678","host_organization_name":"Editorial Team of Recent Advances in Ophthalmology","host_organization_lineage":["https://openalex.org/P4323850678"],"host_organization_lineage_names":["Editorial Team of Recent Advances in Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yanke xinjinzhan","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100396391","display_name":"Wen Wang","orcid":"https://orcid.org/0000-0003-3215-3020","observed_orcids":["https://orcid.org/0000-0003-3215-3020","https://orcid.org/0009-0004-7837-507X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wen Wang","raw_affiliation_strings":["Ji, XU Ge  Zhi, MA Xiao  Kui"],"raw_orcid":"https://orcid.org/0000-0003-3215-3020","affiliations":[{"raw_affiliation_string":"Ji, XU Ge  Zhi, MA Xiao  Kui","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100396391"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26894647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma","display_name":"retinoblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spontaneous-regression","display_name":"spontaneous regression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.9297666549682617},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.9159067869186401},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.9130580425262451},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5096836090087891},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.44357335567474365},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4419293701648712},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4235963523387909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40550553798675537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3860609233379364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.335425466299057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33044588565826416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10574322938919067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09019488096237183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04214617609977722}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2394096037","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XKJZ200004004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764888772","display_name":"Yanke xinjinzhan","issn_l":"1003-5141","issn":["1003-5141"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323850678","host_organization_name":"Editorial Team of Recent Advances in Ophthalmology","host_organization_lineage":["https://openalex.org/P4323850678"],"host_organization_lineage_names":["Editorial Team of Recent Advances in Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yanke xinjinzhan","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2440800267","https://openalex.org/W2027648419","https://openalex.org/W4210960064","https://openalex.org/W2159176485","https://openalex.org/W2051863115","https://openalex.org/W2385142766","https://openalex.org/W2065829633","https://openalex.org/W7634902","https://openalex.org/W7017455553","https://openalex.org/W2192921745"],"abstract_inverted_index":{"Objective":[0],"To":[1],"determine":[2],"the":[3,10,15,43,85,99,103],"frequency":[4],"of":[5,12,19,63,89,105,108],"apoptosis":[6,13,83,101],"and":[7,17,32,52,82],"to":[8],"investigate":[9],"effect":[11],"on":[14],"generating":[16],"developing":[18],"RB.Methods":[20],"Seventeen":[21],"human":[22,65],"RB":[23,78,90],"specimens":[24,67],"were":[25,40,59,72],"selected,":[26],"including":[27],"7":[28],"undifferentiated,":[29],"8":[30],"differentiated,":[31],"2":[33,75],"spontaneous":[34,76,106],"regression":[35,77,107],"tumor":[36],"specimens.":[37,79],"Apoptotic":[38],"cells":[39,58,71],"identified":[41],"with":[42],"transferase(TDT)":[44],"mediated":[45],"duTP":[46],"biotin":[47],"nick":[48],"end":[49],"labeling(TUNEL)":[50],"method":[51],"electron":[53],"microscopy.Results":[54],"A":[55],"few":[56],"apoptotic":[57,70],"found":[60],"in":[61,74],"9":[62],"15":[64],"retinoblastoma":[66],"but":[68],"no":[69,95],"detected":[73],"Conclusion":[80],"Necrosis":[81],"are":[84],"two":[86],"major":[87],"ways":[88],"cell":[91,100],"dying.":[92],"There":[93],"is":[94,102],"sufficient":[96],"evidence":[97],"that":[98],"mechanism":[104],"RB.":[109]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}