{"id":"https://openalex.org/W2394084479","doi":"https://doi.org/10.1056/nejmoa0706728","title":"Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events","display_name":"Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events","publication_year":2008,"publication_date":"2008-03-19","ids":{"openalex":"https://openalex.org/W2394084479","doi":"https://doi.org/10.1056/nejmoa0706728","mag":"2394084479","pmid":"https://pubmed.ncbi.nlm.nih.gov/18354102"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa0706728","doi":"https://doi.org/10.1056/nejmoa0706728","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706728","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706728?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706728?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043655881","display_name":"Sekar Kathiresan","orcid":"https://orcid.org/0000-0002-6724-032X","observed_orcids":["https://orcid.org/0000-0002-6724-032X","https://orcid.org/0000-0002-3711-7101","https://orcid.org/0000-0002-6201-5334"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sekar Kathiresan","raw_affiliation_strings":["Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA. skathiresan@partners.org","Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","Cardiology Division, Massachusetts General Hospital","Departments of Medicine, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA. skathiresan@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Departments of Medicine, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086839394","display_name":"Olle Melander","orcid":"https://orcid.org/0000-0002-2581-484X","observed_orcids":["https://orcid.org/0000-0002-2581-484X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olle Melander","raw_affiliation_strings":["Departments of Clinical Sciences, Hypertension, and Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Sciences, Hypertension, and Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071075743","display_name":"Dragi Anevski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dragi Anevski","raw_affiliation_strings":["Diabetes and Endocrinology","University Hospital Malm\u00f6, Lund University, Malm\u00f6, and Chalmers University of Technology, G\u00f6teborg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology","institution_ids":[]},{"raw_affiliation_string":"University Hospital Malm\u00f6, Lund University, Malm\u00f6, and Chalmers University of Technology, G\u00f6teborg","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111905559","display_name":"Candace Guiducci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candace Guiducci","raw_affiliation_strings":["Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107862545","display_name":"No\u00ebl P. Burtt","orcid":"https://orcid.org/0009-0006-4893-7945","observed_orcids":["https://orcid.org/0009-0006-4893-7945"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"No\u00ebl P. Burtt","raw_affiliation_strings":["Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074610409","display_name":"Charlotta Roos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotta Roos","raw_affiliation_strings":["Diabetes and Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001552586","display_name":"Joel N. Hirschhorn","orcid":"https://orcid.org/0000-0002-1650-7901","observed_orcids":["https://orcid.org/0000-0002-1650-7901"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210162629","display_name":"Children's Hospital","ror":"https://ror.org/0511k4970","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210162629"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["TN","US"],"is_corresponding":false,"raw_author_name":"Joel N. Hirschhorn","raw_affiliation_strings":["Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","Division of Endocrinology and Genetics, Children's Hospital","Genetics, Harvard Medical School","Pediatrics, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Division of Endocrinology and Genetics, Children's Hospital","institution_ids":["https://openalex.org/I4210162629"]},{"raw_affiliation_string":"Genetics, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Pediatrics, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108495483","display_name":"Goran L. Berglund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00f6ran Berglund","raw_affiliation_strings":["Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004404785","display_name":"Bo Hedblad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Hedblad","raw_affiliation_strings":["Epidemiological Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiological Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074771810","display_name":"Leif Groop","orcid":"https://orcid.org/0000-0002-0187-3263","observed_orcids":["https://orcid.org/0000-0002-0187-3263"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Leif Groop","raw_affiliation_strings":["Diabetes and Endocrinology","Helsinki University Hospital, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology","institution_ids":[]},{"raw_affiliation_string":"Helsinki University Hospital, Helsinki","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340817","display_name":"David Altshuler","orcid":"https://orcid.org/0000-0002-7250-4107","observed_orcids":["https://orcid.org/0000-0002-7250-4107"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Altshuler","raw_affiliation_strings":["Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital","Departments of Medicine, Harvard Medical School","Genetics, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Departments of Medicine, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Genetics, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011797463","display_name":"Christopher Newton\u2010Cheh","orcid":"https://orcid.org/0000-0002-3001-9111","observed_orcids":["https://orcid.org/0000-0002-3001-9111"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Newton-Cheh","raw_affiliation_strings":["Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","Cardiology Division, Massachusetts General Hospital","Departments of Medicine, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Departments of Medicine, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077037910","display_name":"Marju Orho\u2010Melander","orcid":"https://orcid.org/0000-0002-3578-2503","observed_orcids":["https://orcid.org/0000-0002-3578-2503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marju Orho-Melander","raw_affiliation_strings":["Diabetes and Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":42.0594,"has_fulltext":false,"cited_by_count":696,"citation_normalized_percentile":{"value":0.99896745,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"358","issue":"12","first_page":"1240","last_page":"1249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.20319999754428864,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7519999742507935},{"id":"https://openalex.org/keywords/genotype-score","display_name":"genotype score","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.6299999952316284},{"id":"https://openalex.org/keywords/risk-reclassification","display_name":"risk reclassification","score":0.8859999775886536},{"id":"https://openalex.org/keywords/malmo-diet-and-cancer-study","display_name":"Malm\u00f6 Diet and Cancer Study","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7821515202522278},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7707107067108154},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7170314192771912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.665703296661377},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6219062805175781},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4782258868217468},{"id":"https://openalex.org/C2776258521","wikidata":"https://www.wikidata.org/wiki/Q4117942","display_name":"Diet and cancer","level":3,"score":0.42377611994743347},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.4199938476085663},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.40496331453323364},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3682246506214142},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2661275863647461},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1581866443157196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14765119552612305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05707848072052002}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejmoa0706728","doi":"https://doi.org/10.1056/nejmoa0706728","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706728","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706728?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:18354102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18354102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:research.chalmers.se:100584","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/100584","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1056/nejmoa0706728","doi":"https://doi.org/10.1056/nejmoa0706728","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa0706728","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa0706728?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1724197636","display_name":"Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the Community","funder_award_id":"K23HL083102","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4795894112","display_name":"Genetic determinants of cardiac repolarization","funder_award_id":"K23HL080025","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2394084479.pdf"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W171150731","https://openalex.org/W1499959019","https://openalex.org/W1528479054","https://openalex.org/W1556944648","https://openalex.org/W1966714873","https://openalex.org/W1972614730","https://openalex.org/W1986550414","https://openalex.org/W1991541318","https://openalex.org/W1995751421","https://openalex.org/W1997297210","https://openalex.org/W2036198235","https://openalex.org/W2042140336","https://openalex.org/W2043993231","https://openalex.org/W2045697402","https://openalex.org/W2045868752","https://openalex.org/W2048036880","https://openalex.org/W2048755332","https://openalex.org/W2067539811","https://openalex.org/W2081632741","https://openalex.org/W2090443364","https://openalex.org/W2090568158","https://openalex.org/W2095908267","https://openalex.org/W2097587917","https://openalex.org/W2110124859","https://openalex.org/W2112316706","https://openalex.org/W2120451046","https://openalex.org/W2140079333","https://openalex.org/W2142769596","https://openalex.org/W2145126338","https://openalex.org/W2146750742","https://openalex.org/W2148635162","https://openalex.org/W2152664025","https://openalex.org/W2157995113","https://openalex.org/W2303043072","https://openalex.org/W4238251256"],"related_works":["https://openalex.org/W7070762608","https://openalex.org/W2159219444","https://openalex.org/W2604231946","https://openalex.org/W2530498238","https://openalex.org/W4238353441","https://openalex.org/W2137249087","https://openalex.org/W2135313485","https://openalex.org/W2553476028","https://openalex.org/W1778245107","https://openalex.org/W2104557985"],"abstract_inverted_index":{"BACKGROUND:":[0],"Common":[1],"single-nucleotide":[2],"polymorphisms":[3],"(SNPs)":[4],"that":[5,26,231,240,255],"are":[6,256],"associated":[7,183,257],"with":[8,117,184,226,238,258],"blood":[9],"low-density":[10],"lipoprotein":[11,15],"(LDL)":[12],"or":[13,70,122,264],"high-density":[14],"(HDL)":[16],"cholesterol":[17,72,133,151,266],"modestly":[18,285],"affect":[19],"lipid":[20,195],"levels.":[21],"We":[22,40,60,88],"tested":[23],"the":[24,34,50,54,63,80,83,95,98,105,129,201,207,214,227,233,244],"hypothesis":[25],"a":[27,76,175,220],"combination":[28],"of":[29,36,53,82,85,114,119,131,200,229,251,262],"such":[30],"SNPs":[31,42,66,111,254],"contributes":[32],"to":[33,93,97,104,138,144,156,162],"risk":[35,209,224,270,281,288],"cardiovascular":[37,51,100,177,186,274],"disease.":[38,275],"METHODS:":[39],"studied":[41],"at":[43],"nine":[44,110,252],"loci":[45],"in":[46,102,188,223,260],"5414":[47],"subjects":[48,173,292],"from":[49,135,153],"cohort":[52],"Malm\u00f6":[55],"Diet":[56],"and":[57,67,73],"Cancer":[58],"Study.":[59],"first":[61,99,176],"validated":[62,253],"association":[64,116],"between":[65],"either":[68,120],"LDL":[69,121,132,263],"HDL":[71,123,150,265],"subsequently":[74],"created":[75],"genotype":[77,106,127,180,202,234,245,249],"score":[78,181,203,250,277],"on":[79],"basis":[81],"number":[84],"unfavorable":[86],"alleles.":[87],"used":[89],"Cox":[90],"proportional-hazards":[91],"models":[92,189,230],"determine":[94],"time":[96],"event":[101],"relation":[103],"score.":[107,246],"RESULTS:":[108],"All":[109],"showed":[112],"replication":[113],"an":[115,268],"levels":[118,196,261],"cholesterol.":[124],"With":[125],"increasing":[126],"scores,":[128],"level":[130],"increased":[134],"152":[136],"mg":[137,140,155,158],"171":[139],"per":[141,147,159,165],"deciliter":[142,160],"(3.9":[143],"4.4":[145],"mmol":[146,164],"liter),":[148],"whereas":[149],"decreased":[152],"60":[154],"51":[157],"(1.6":[161],"1.3":[163],"liter).":[166],"During":[167],"follow-up":[168],"(median,":[169],"10.6":[170],"years),":[171],"238":[172],"had":[174],"event.":[178],"The":[179,198,276],"was":[182,219,267],"incident":[185,273],"disease":[187],"adjusted":[190],"for":[191,272,290],"covariates":[192],"including":[193],"baseline":[194],"(P<0.001).":[197],"use":[199,228],"did":[204,241,278,284],"not":[205,242,279],"improve":[206,280,286],"clinical":[208,287,295],"prediction,":[210],"as":[211,236],"assessed":[212],"by":[213],"C":[215],"statistic.":[216],"However,":[217],"there":[218],"significant":[221],"improvement":[222],"classification":[225],"included":[232],"score,":[235],"compared":[237],"those":[239],"include":[243],"CONCLUSIONS:":[247],"A":[248],"modulation":[259],"independent":[269],"factor":[271],"discrimination":[282],"but":[283],"reclassification":[289],"individual":[291],"beyond":[293],"standard":[294],"factors.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":45},{"year":2012,"cited_by_count":58}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
