{"id":"https://openalex.org/W2394029453","doi":null,"title":"Expression and Function of TLR2 in Leucocytes from Patients with Type 2 Diabetes","display_name":"Expression and Function of TLR2 in Leucocytes from Patients with Type 2 Diabetes","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2394029453","mag":"2394029453"},"language":"en","primary_location":{"id":"mag:2394029453","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYFX201009006.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhejiang Journal of Preventive Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007002719","display_name":"Qifen Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qifen Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007002719"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32073338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.753000020980835},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":1.0},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tnf-alpha-secretion","display_name":"TNF-alpha secretion","score":0.847000002861023},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4909999966621399},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.8830431699752808},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7264934182167053},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6046271324157715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5977156758308411},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5943537354469299},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5844562649726868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5717756748199463},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5455935597419739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48222100734710693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36710119247436523},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3227521479129791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2798425257205963},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2140079140663147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06740549206733704}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2394029453","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYFX201009006.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhejiang Journal of Preventive Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2362871068","https://openalex.org/W2763751155","https://openalex.org/W2155734075","https://openalex.org/W178629481","https://openalex.org/W266930304","https://openalex.org/W2742941924","https://openalex.org/W2619848908","https://openalex.org/W2082811090","https://openalex.org/W4226332851","https://openalex.org/W2733061790"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,62,84,173],"TLR2-mediated":[4,174],"immune":[5,175],"function":[6,176],"in":[7,23,27,54,73,79,83,95,105,112,129,132,142,146,152,159,165,170],"peripheral":[8,28],"blood":[9,29],"mononuclear":[10],"cells":[11,167],"of":[12,20,59,64,71,93,121,150],"patients":[13,40],"with":[14,126,139],"type":[15,37],"2":[16,38],"diabetes.Methods":[17],"The":[18,69,162],"expression":[19,58,70,92,104,120,164],"TLR2":[21,60,72,94,103,163],"protein":[22],"lymphocytes,monocytes":[24],"and":[25,41,56,61,75,98],"granulocytes":[26],"were":[30,101,107],"detected":[31],"by":[32,49,90,118],"flow":[33],"cytometry":[34],"among":[35],"35":[36],"diabetes":[39,85,99,113,133,147,160,171],"30":[42],"controls.The":[43],"single":[44],"nucleus":[45],"cell":[46],"was":[47,66],"activated":[48,89,117,125,138],"HKLM":[50,127],"after":[51,115,123],"being":[52,88,116,124],"isolated":[53],"vitro":[55],"cultured.The":[57],"secretion":[63,149],"TNF-\u03b1":[65,122,151],"also":[67],"tested.Results":[68],"lymphocytes":[74],"monocytes":[76],"were(1.75\u00b10.50)%":[77],"and(28.38\u00b113.92)%":[78],"controls,lower":[80],"than":[81,110,136],"those":[82,137],"group((2.12\u00b10.84)%":[86],"and(35.09\u00b112.69)%),respectively(P0.05).After":[87],"HKLM,the":[91],"both":[96],"controls":[97,106,130,143,153],"groups":[100],"increased.The":[102],"significantly":[108,154],"higher":[109,135],"that":[111,158],"group":[114],"HKLM(P0.05).The":[119],"were(83.67\u00b140.87)pg/mL":[128],"and(40.82\u00b132.52)pg/mL":[131],"group,markedly":[134],"PBS((14.32\u00b19.87)":[140],"pg/mL":[141,145],"and(18.36\u00b111.27)":[144],"group)(P0.05).The":[148],"increased":[155,169],"comparing":[156],"to":[157],"group.Conclusion":[161],"nuclear":[166],"is":[168,177],"patients,but":[172],"damaged.":[178]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
