{"id":"https://openalex.org/W2393924609","doi":null,"title":"Serum cytokines in patients with multiple organ failure following open-heart-surgery","display_name":"Serum cytokines in patients with multiple organ failure following open-heart-surgery","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2393924609","mag":"2393924609"},"language":"en","primary_location":{"id":"mag:2393924609","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-DSJY200005029.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431658","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0001-7118-815X","observed_orcids":["https://orcid.org/0000-0001-7118-815X"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Yong, ZHU HengShan  Center of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong, ZHU HengShan  Center of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100431658"],"corresponding_institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36362205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.06939999759197235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9879999756813049},{"id":"https://openalex.org/keywords/open-heart-surgery","display_name":"open heart surgery","score":0.7950000166893005},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.7722369432449341},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.7120041847229004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6827892065048218},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6234344244003296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49904298782348633},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.47888869047164917},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4745018184185028},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4626608192920685},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.4325811266899109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3793925642967224},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3715756833553314}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393924609","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-DSJY200005029.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019119774","https://openalex.org/W2382898635","https://openalex.org/W2364813736","https://openalex.org/W2351011592","https://openalex.org/W2515085573","https://openalex.org/W2363870396","https://openalex.org/W2389134020","https://openalex.org/W1473224842","https://openalex.org/W51541575","https://openalex.org/W2382764559"],"abstract_inverted_index":{"AIM":[0],"To":[1],"evaluate":[2],"the":[3,7,95,113],"clinical":[4],"significance":[5],"of":[6,48,93,112,120],"changes":[8],"in":[9,98,105],"serum":[10],"tumor":[11],"necrosis":[12],"factor-\u03b1":[13],"(TNF-\u03b1),":[14],"interleukin-\u03b2":[15],"(IL-1\u03b2),":[16],"interleukin-6":[17],"(IL-6),":[18],"interleukin-8":[19],"(IL-8).":[20],"METHODS":[21],"Thirteen":[22],"patients":[23],"with":[24],"multiple":[25],"organ":[26],"failure":[27],"following":[28],"openheartsurgery":[29],"were":[30,38],"selected.":[31],"Serum":[32],"TNF\u03b1,":[33,106],"IL1\u03b2,":[34],"IL6,":[35,99],"IL8":[36,78,100],"levels":[37,47],"measured":[39],"by":[40],"enzymelinked":[41],"immunosorbent":[42],"assay":[43],"(ELISA).":[44],"RESULTS":[45],"The":[46,91,109],"plasma":[49],"TNF\u03b1":[50],"(0.61\u00b10.08),":[51],"(0.81\u00b10.09)":[52],"vs":[53,62,73,81],"(0.20\u00b10.05)":[54],"\u03bcg\u00b7L":[55,64,75,83],"-1":[56,65,76,84],"(p0.05,":[57],"0.01);":[58,67],"IL1\u03b2":[59],"(0.52\u00b10.09),":[60],"(0.69\u00b10.04)":[61],"(0.16\u00b10.03)":[63],"(P0.01,":[66],"IL6":[68],"(0.41\u00b1":[69],"0.08":[70],"),":[71],"(0.56\u00b10.07)":[72],"(0.17\u00b10.03)":[74],"(P0.05,0.05);":[77],"(3.70\u00b10.80),":[79],"(4.92\u00b10.78)":[80],"(1.6\u00b10.40)":[82],"(P0.05,":[85],"0.05)":[86],"rose":[87],"markedly":[88],"after":[89,122],"MOF.":[90],"time":[92],"reaching":[94],"peak":[96],"value":[97],"was":[101],"slower":[102],"than":[103],"that":[104],"IL1\u03b2.":[107],"CONCLUSION":[108],"abnormal":[110],"release":[111],"cellular":[114],"factors":[115],"is":[116],"an":[117],"important":[118],"cause":[119],"MOF":[121],"openheartsurgery.":[123],"TNF\u03b1,IL1\u03b2":[124],"are":[125],"triggling":[126],"factors.":[127]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}