{"id":"https://openalex.org/W2393821995","doi":null,"title":"[Clinical significance and relationship of expression of matrix metalloproteinase-2 mRNA with breast cancer metastasis].","display_name":"[Clinical significance and relationship of expression of matrix metalloproteinase-2 mRNA with breast cancer metastasis].","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2393821995","mag":"2393821995","pmid":"https://pubmed.ncbi.nlm.nih.gov/15938935"},"language":"zh","primary_location":{"id":"pmid:15938935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15938935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wai ke za zhi [Chinese journal of surgery]","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108579036","display_name":"Chun Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Hua Xiao","raw_affiliation_strings":["Department of Breast, Tianjin Medical University Cancer Hospital, Tianjin 300060, China. Email: llxxqq80@163.com","Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast, Tianjin Medical University Cancer Hospital, Tianjin 300060, China. Email: llxxqq80@163.com","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744698","display_name":"Yu Feng","orcid":"https://orcid.org/0000-0003-4935-5366","observed_orcids":["https://orcid.org/0000-0003-4935-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Mei Feng","raw_affiliation_strings":["Biochemistry and Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113951110","display_name":"Xiao Qing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Qing Li","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110413263","display_name":"Xi Shan Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi-Shan Hao","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1157,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48093111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"9","first_page":"599","last_page":"604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mmp-2-mrna-expression","display_name":"MMP-2 mRNA expression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7889999747276306},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7345684766769409},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7139513492584229},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6797058582305908},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6696615219116211},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.6662686467170715},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6496341824531555},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5963153839111328},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5318365097045898},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48304468393325806},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3780284821987152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3623533248901367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30886510014533997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1459915041923523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10728493332862854},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15938935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15938935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wai ke za zhi [Chinese journal of surgery]","raw_type":"English Abstract"},{"id":"mag:2393821995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15938935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2372168188","https://openalex.org/W2382944615","https://openalex.org/W2373164735","https://openalex.org/W3031998357","https://openalex.org/W2978576771","https://openalex.org/W2033334122","https://openalex.org/W2363353774","https://openalex.org/W4248435845","https://openalex.org/W1998202850","https://openalex.org/W2896170684"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"discuss":[2],"the":[3,12,44,186],"clinical":[4,35],"significance":[5],"of":[6,14,27,46,78,122,188],"matrix":[7],"metalloproteinase-2":[8],"(MMP-2)":[9],"mRNA":[10,16,25,48,56,76,101,120,147,162,181],"and":[11,33,42,158,174],"relationship":[13],"MMP-2":[15,24,47,55,79,100,123,146,161,180],"expression":[17,26,49,57,77,102,121,148,163,182],"with":[18,50,151,177,185],"breast":[19,29,36,67,189],"cancer":[20,37,68],"metastasis.":[21],"METHOD:":[22],"Detect":[23],"30":[28,59],"cancer,":[30],"metastatic":[31,60,171],"lymphnode":[32,61,134,170],"116":[34],"samples":[38],"by":[39],"flurence-quantitative":[40],"RT-PCR":[41],"analysis":[43],"relativity":[45],"clinical,":[51],"pathology":[52],"factors.":[53],"RESULTS:":[54],"in":[58,65,80,88,103,110,124,133,166],"is":[62,85,107,130,149,164,183],"lower":[63,86,108,131],"than":[64,87,109,126,132],"primary":[66],"(t":[69,93,113,139],"=":[70,94,114,140],"-3.293,":[71],"P":[72,96,116,142],"<":[73,97,117,143],"0.05).":[74,98,118,144],"The":[75,99,119,145],"tumor":[81,89,178],">":[82],"2":[83,91],"cm":[84,92],"</=":[90],"1.936,":[95],"stage":[104,111],"II,":[105],"III":[106],"I":[112],"2.466,":[115],"more":[125],"4":[127],"lymphnodes":[128],"positive":[129,138],"1":[135],"-":[136],"3":[137],"3.202,":[141],"irrelated":[150],"tissue":[152],"grade,":[153],"pathologic":[154],"type,":[155],"ER,":[156],"PR":[157],"Her-2.":[159],"CONCLUSIONS:":[160],"up-regulated":[165],"early":[167,172],"clinic":[168],"stage,":[169,173],"down":[175],"regulated":[176],"progressing.":[179],"related":[184],"metastasis":[187],"cancer.":[190]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}