{"id":"https://openalex.org/W2393749834","doi":null,"title":"Comparison of latanoprost and timolol in patients with primary open-angle glaucoma and ocular hypertension","display_name":"Comparison of latanoprost and timolol in patients with primary open-angle glaucoma and ocular hypertension","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2393749834","mag":"2393749834"},"language":"en","primary_location":{"id":"mag:2393749834","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XKJZ199906008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764888772","display_name":"Yanke xinjinzhan","issn_l":"1003-5141","issn":["1003-5141"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323850678","host_organization_name":"Editorial Team of Recent Advances in Ophthalmology","host_organization_lineage":["https://openalex.org/P4323850678"],"host_organization_lineage_names":["Editorial Team of Recent Advances in Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yanke xinjinzhan","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qian Shao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qian Shao","raw_affiliation_strings":["Hong,SUN Xin  Huai,DAI Jin  Hui,GUO Wen  Yi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hong,SUN Xin  Huai,DAI Jin  Hui,GUO Wen  Yi","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27463392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latanoprost","display_name":"latanoprost","score":1.0},{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":1.0},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":1.0},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.8790000081062317},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha-analogue","display_name":"prostaglandin F2alpha analogue","score":0.722000002861023},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ocular-hypotensive-agents","display_name":"ocular hypotensive agents","score":0.8109999895095825},{"id":"https://openalex.org/keywords/conjunctival-hyperemia","display_name":"conjunctival hyperemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/corneal-epithelial-erosion","display_name":"corneal epithelial erosion","score":0.8920000195503235},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.6869999766349792},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.9954207539558411},{"id":"https://openalex.org/C2778073030","wikidata":"https://www.wikidata.org/wiki/Q413994","display_name":"Timolol","level":3,"score":0.962104082107544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7427099347114563},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6738608479499817},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6286213994026184},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.6259071826934814},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5900049805641174},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.5454228520393372},{"id":"https://openalex.org/C2780276452","wikidata":"https://www.wikidata.org/wiki/Q2193376","display_name":"Travoprost","level":4,"score":0.4575656056404114},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3291933238506317}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393749834","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XKJZ199906008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764888772","display_name":"Yanke xinjinzhan","issn_l":"1003-5141","issn":["1003-5141"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323850678","host_organization_name":"Editorial Team of Recent Advances in Ophthalmology","host_organization_lineage":["https://openalex.org/P4323850678"],"host_organization_lineage_names":["Editorial Team of Recent Advances in Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yanke xinjinzhan","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2150119670","https://openalex.org/W2363214090","https://openalex.org/W2076260416","https://openalex.org/W4391916307","https://openalex.org/W1970171221","https://openalex.org/W2358986306","https://openalex.org/W6946238343","https://openalex.org/W2597787521","https://openalex.org/W2611484262","https://openalex.org/W1996539435"],"abstract_inverted_index":{"Objective":[0],"To":[1],"compare":[2],"the":[3,97,183],"ocular":[4,38],"hypotensive":[5],"efficacy":[6,83],"and":[7,73,169],"side":[8],"effects":[9],"of":[10,29,64,84,99,122,130,185],"latanoprost(PhXA41),a":[11],"new":[12],"phenyl-substituted":[13],"prostaglandin":[14],"F":[15],"2\u03b1":[16],"-isopropyl":[17],"ester":[18],"analogue,with":[19],"timolol":[20,58,104,151,178],"in":[21,117,120,138,150,172],"patients":[22,47],"with":[23,33,125],"elevated":[24],"intraoular":[25],"pressure(IOP).Methods":[26],"A":[27],"total":[28],"34":[30],"patients(66":[31],"eyes)":[32],"primary":[34],"open-angle":[35],"glaucoma":[36,191],"or":[37,55],"hypertension":[39],"were":[40,136],"randomized,17(32":[41],"eyes)to":[42,45],"latanoprost,another":[43],"17(34":[44],"timolol.The":[46],"received":[48],"either":[49],"0.05g\u00b7L":[50,160],"-1":[51,57,161,177],"latanoprost":[52,85,162],"once":[53,164],"daily":[54,60,165],"5g\u00b7L":[56,176],"twice":[59,180],"for":[61,127,190],"a":[62,114],"period":[63],"12":[65,79,100],"weeds.Results":[66],"IOP":[67,95,106,174],"was":[68,86,157],"significantly":[69],"lowered":[70],"(":[71,153],"P0.001)":[72],"maintained":[74],"by":[75,102,107,145],"both":[76],"medications":[77],"over":[78],"weeks.At":[80],"all":[81],"visits,the":[82],"statistically":[87],"superior":[88],"to":[89],"timolol(":[90],"P0.05%)":[91],".":[92,111],"Latanoprost":[93,112],"reduced":[94,105],"at":[96],"end":[98],"weeks":[101],"9.5\u00b13.1mmHg(36.8%)(1mmHg=0.133kPa),while":[103],"7.4\u00b12.6mmHg":[108],"(29.6%)(":[109],"P0.01)":[110],"induced":[113],"slight":[115],"increase":[116],"conjunctival":[118],"hyperemia":[119],"23.5%":[121],"treated":[123],"patients,compared":[124],"11.8%":[126],"timolol.Sporadic":[128],"episodes":[129],"mild":[131],"punctate":[132],"corneal":[133],"epithelial":[134],"erosions":[135],"observed":[137],"latanoprost-treated":[139],"eyes.":[140],"The":[141],"heart":[142],"rate":[143],"dropped":[144],"4":[146],"beats":[147],"per":[148],"minute":[149],"group":[152],"P0.05":[154],").Conclusion":[155],"It":[156],"demonstrated":[158],"that":[159],"taken":[163,179],"is":[166],"well":[167],"tolerated":[168],"more":[170],"effective":[171],"reducing":[173],"than":[175],"daily.Thus,latanoprost":[181],"has":[182],"potential":[184],"becoming":[186],"an":[187],"excellent":[188],"candidate":[189],"medication.":[192]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}