{"id":"https://openalex.org/W2393692041","doi":null,"title":"The change of insulin secretion function in pre-diabetic stages and in different diagnostic duration of type 2 diabetes mellitus","display_name":"The change of insulin secretion function in pre-diabetic stages and in different diagnostic duration of type 2 diabetes mellitus","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2393692041","mag":"2393692041"},"language":"en","primary_location":{"id":"mag:2393692041","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ200406003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764863165","display_name":"Zhongguo laonianxue zazhi","issn_l":"1005-9202","issn":["1005-9202"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001555","host_organization_name":"Chinese Society of Gerontology","host_organization_lineage":["https://openalex.org/P4324001555"],"host_organization_lineage_names":["Chinese Society of Gerontology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo laonianxue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100966431","display_name":"Jin Wen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jin Wen","raw_affiliation_strings":["sheng,LIAO Hong  qing, WANG Guo  hua,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"sheng,LIAO Hong  qing, WANG Guo  hua,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100966431"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/impaired-fasting-glucose","display_name":"impaired fasting glucose","score":0.8450000286102295},{"id":"https://openalex.org/keywords/diabetes-duration","display_name":"diabetes duration","score":0.5849999785423279},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5789999961853027},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.8289999961853027},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8370000123977661},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5600000023841858},{"id":"https://openalex.org/keywords/diabetes-screening","display_name":"diabetes screening","score":0.40799999237060547},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.503000020980835},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.699999988079071},{"id":"https://openalex.org/keywords/homa","display_name":"HOMA","score":0.5}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.807256817817688},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7824581861495972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7583266496658325},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7171459197998047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6479337215423584},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5214430689811707},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.47865259647369385},{"id":"https://openalex.org/C2777185836","wikidata":"https://www.wikidata.org/wiki/Q3306264","display_name":"Impaired fasting glucose","level":5,"score":0.4157482981681824},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.3027181029319763}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393692041","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ200406003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764863165","display_name":"Zhongguo laonianxue zazhi","issn_l":"1005-9202","issn":["1005-9202"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001555","host_organization_name":"Chinese Society of Gerontology","host_organization_lineage":["https://openalex.org/P4324001555"],"host_organization_lineage_names":["Chinese Society of Gerontology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo laonianxue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2369647680","https://openalex.org/W2164180472","https://openalex.org/W2005775898","https://openalex.org/W2167508764","https://openalex.org/W2500015104","https://openalex.org/W7100917590","https://openalex.org/W7099863335","https://openalex.org/W2077149049","https://openalex.org/W94816563","https://openalex.org/W2103659234"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3,10,41,44,73,114,125,175,183,188,196,206,231,235,251,257,265,283,287,294,306,314,327,354,408,422],"dynamic":[4],"changes":[5,420],"of":[6,12,43,60,98,148,187,195,224,238,260,297,309,329,357,392,399,411,414,434],"insulin":[7,96,118,126,146,185,239,261,295,310,315,337,348,362,400,415,436],"secretion":[8,401,416],"during":[9,230,302],"progression":[11,232],"type":[13,68],"2":[14,19,52,69],"diabetes":[15,234,288,379],"mellitus":[16],"Methods":[17],"Type":[18],"diabetic":[20,143,255,390,405],"inpatients":[21],"with":[22,136,150,264,293,336,346,361],"different":[23],"progress":[24],"were":[25,106,220,290,418],"recruited":[26],"and":[27,51,65,93,102,122,173,204,213,245,280,286,311,368,377,425,429],"grouped":[28],"by":[29,120,166,241],"one":[30],"year":[31,202,424,427],"duration":[32,155,171,266,289,428],"added":[33],"till":[34,177,208],"to":[35,152,157,159,178,192,209,233],"greater":[36],"than":[37],"10":[38,179],"years":[39,154,170,180,211,216],"And":[40],"individuals":[42],"following":[45],"groups:":[46],"normal":[47,130,137,366],"glucose":[48,62,89,121,138,242,249,279,284,328,367,375,393],"(both":[49],"fasting":[50,115,145,248,278,347],"hour":[53],"normal),":[54],"suspicious":[55],"dysglycaemia":[56],"(SDG),":[57],"various":[58,388],"forms":[59],"impaired":[61,247,374],"regulation":[63,376],"(IGR)":[64],"newly":[66,378],"diagnosed":[67],"diabetes,":[70],"came":[71],"from":[72,200,437],"screened":[74,112,228,320],"people,":[75,321],"for":[76,271,403],"whose":[77],"yearly":[78],"health":[79],"examination":[80],"we":[81],"are":[82],"responsible":[83],"All":[84],"participators":[85],"received":[86],"75":[87],"oral":[88],"tolerance":[90],"test":[91],"(OGTT)":[92],"synchronic":[94],"serum":[95],"detections":[97],"five":[99],"time":[100],"points,":[101],"other":[103],"relevant":[104],"parameters":[105],"also":[107,219],"measured":[108],"Results":[109],"1)":[110],"In":[111,141,227,253,319],"people":[113,229],"insulin,":[116,305],"maximal":[117,184,304,435],"stimulated":[119],"area":[123,281,312],"under":[124,282,313],"curve":[127,285,316],"in":[128,168,214,365,373,407],"non":[129],"groups":[131,190,370,380],"all":[132],"significantly":[133,317],"elevated":[134],"compared":[135],"group":[139,172,217],"2)":[140],"known":[142,254,404],"patients,":[144,406],"levels":[147,186,296,363],"those":[149],"1":[151,201,423],"5":[153,210],"continued":[156],"compensate":[158],"a":[160,221,322],"higher":[161],"level,":[162,277],"but":[163,339,371],"dropped":[164],"abruptly":[165],"half":[167,194,225],"6":[169,215,426],"remained":[174,205],"level":[176,199,207],"groups;":[181],"while":[182],"same":[189],"decreased":[191,243,262,440],"be":[193],"previous":[197],"compensated":[198],"duration,":[203],"group,":[212],"there":[218,417],"sudden":[222],"drop":[223,413],"3)":[226],"increased":[236,258,307,432],"fold":[237,259,308],"induced":[240],"gradually,":[244],"isolated":[246],"was":[250,334,343],"poorest":[252],"patients":[256],"slowly":[263],"increasing":[267],"4)":[268],"After":[269],"adjustment":[270],"age,":[272],"body":[273,340,358],"mass":[274,341,359],"index,":[275],"triglyceride":[276],"negatively":[291],"correlated":[292,335],"0,":[298,330],"30,":[299,331],"60":[300],"min":[301,333],"OGTT,":[303],"5)":[318],"multivariate":[323],"regression":[324],"showed":[325,386],"that":[326,353,387],"180":[332],"positively,":[338],"index":[342,360],"only":[344],"related":[345],"positively":[349],"Further":[350],"analysis":[351],"demonstrated":[352],"positive":[355],"correlation":[356],"presented":[364,395],"SDG":[369],"not":[372],"Conclusions":[381],"This":[382],"cross":[383],"sectional":[384],"study":[385],"pre":[389],"types":[391],"metabolism":[394],"substantially":[396],"compensatory":[397],"increase":[398],"But":[402],"general":[409],"tendency":[410],"gradually":[412],"abrupt":[419],"at":[421],"these":[430],"patients'":[431],"folds":[433],"basal":[438],"value":[439],"continuously":[441]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}