{"id":"https://openalex.org/W2393572192","doi":null,"title":"Protective effects of sodium aescinate preconditioning on tourniquet-induced limb ischemia-reperfusion injury","display_name":"Protective effects of sodium aescinate preconditioning on tourniquet-induced limb ischemia-reperfusion injury","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2393572192","mag":"2393572192"},"language":"en","primary_location":{"id":"mag:2393572192","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YIYA201016016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764998623","display_name":"Jiangsu Medical Journal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323283970","host_organization_name":"Jiangsu Pharmaceutical Editorial Department","host_organization_lineage":["https://openalex.org/P4323283970"],"host_organization_lineage_names":["Jiangsu Pharmaceutical Editorial Department"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jiangsu Medical Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102968240","display_name":"Gang Xu","orcid":"https://orcid.org/0000-0001-6933-762X","observed_orcids":["https://orcid.org/0000-0001-6933-762X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gang Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102968240"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12117","display_name":"Muscle and Compartmental Disorders","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-aescinate","display_name":"sodium aescinate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tourniquet","display_name":"tourniquet","score":0.7540000081062317},{"id":"https://openalex.org/keywords/limb-ischemia-reperfusion-injury","display_name":"limb ischemia-reperfusion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lower-limb","display_name":"lower extremity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7979999780654907},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.968999981880188},{"id":"https://openalex.org/keywords/blood-lactate","display_name":"blood lactate","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2779400597","wikidata":"https://www.wikidata.org/wiki/Q1132870","display_name":"Tourniquet","level":2,"score":0.9257330894470215},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7937095165252686},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.668137788772583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6322540044784546},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5683926343917847},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5654234290122986},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.512043297290802},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.5018231868743896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1797773540019989},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.11867871880531311}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393572192","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YIYA201016016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764998623","display_name":"Jiangsu Medical Journal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323283970","host_organization_name":"Jiangsu Pharmaceutical Editorial Department","host_organization_lineage":["https://openalex.org/P4323283970"],"host_organization_lineage_names":["Jiangsu Pharmaceutical Editorial Department"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jiangsu Medical Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992153288","https://openalex.org/W2385792366","https://openalex.org/W2362023597","https://openalex.org/W2383502965","https://openalex.org/W2354847218","https://openalex.org/W1969246444","https://openalex.org/W2384987210","https://openalex.org/W2172930808","https://openalex.org/W2349139076","https://openalex.org/W118303831"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2],"the":[3,15,52,118],"protective":[4],"effects":[5],"of":[6,14,30,71,104,117],"sodium":[7,35,110],"aescinate":[8,36,111],"preconditioning":[9],"on":[10],"tourniquet-induced":[11,114],"ischemia-reperfusion(I-R)":[12],"injury":[13,116],"lower":[16,119],"extreamities.Methods":[17],"Sixty":[18],"patients":[19],"were":[20,56],"randomly":[21],"allocated":[22],"to":[23],"three":[24,90],"groups":[25,103],"with":[26,81,92,109],"20":[27,64],"cases":[28],"each.Groups":[29],"A":[31,105],"and":[32,39,61,76,95,106,125,128],"B":[33],"received":[34,49],"5":[37],"mg":[38],"10":[40],"mg,respectively,at":[41],"30":[42],"min":[43],"before":[44,58],"tourniquet":[45,59,67],"inflation,while":[46],"group":[47,93],"C":[48],"placebo":[50],"as":[51],"control.Venous":[53],"blood":[54,72],"samples":[55],"obtained":[57],"inflation(T0)":[60],"at":[62,83,87,100],"5(T1),10(T2),and":[63],"min(T3)":[65],"after":[66],"deflation":[68],"for":[69],"measurement":[70],"lactate(Lac),nitrous":[73],"monoxide(NO),malondialdehyde(MDA)":[74],"concentration":[75],"superoxide":[77],"dismutase(SOD)":[78],"activity.Results":[79],"Compared":[80],"that":[82],"T0,Lac":[84],"increased":[85],"significantly":[86],"T1-T3":[88,101],"in":[89,102],"groups(P0.05).Compared":[91],"C,MDA":[94],"NO":[96,129],"increased,while":[97],"SOD":[98,123],"decreased,significantly":[99],"B(P0.05).Conclusion":[107],"Pretreatment":[108],"can":[112],"protect":[113],"I-R":[115],"extreamities,possibly":[120],"through":[121],"increasing":[122],"activity":[124],"decreasing":[126],"MDA":[127],"levels.":[130]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}