{"id":"https://openalex.org/W2393334005","doi":null,"title":"Effects of tumor necrosis factor-alpha on expressions of osteoprotegerin mRNA and OPG protein in mouse marrow stromal MBA-1 cell lines","display_name":"Effects of tumor necrosis factor-alpha on expressions of osteoprotegerin mRNA and OPG protein in mouse marrow stromal MBA-1 cell lines","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2393334005","mag":"2393334005"},"language":"en","primary_location":{"id":"mag:2393334005","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGZS200501001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764876134","display_name":"Chinese Journal of Osteoporosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316229","host_organization_name":"University of California, San Francisco","host_organization_lineage":["https://openalex.org/P4310316229","https://openalex.org/P4310316177"],"host_organization_lineage_names":["University of California, San Francisco","University of California"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Osteoporosis","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031807870","display_name":"Liao Er","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liao Er","raw_affiliation_strings":["'yuan, WANG Yunlin, et al"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'yuan, WANG Yunlin, et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031807870"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":1.0},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5799999833106995},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.828000009059906},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.9524701833724976},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.822403609752655},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7399471998214722},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7156082391738892},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5991830825805664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5555482506752014},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5301533341407776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.526377260684967},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.5160669684410095},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5041216611862183},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4599335491657257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4049479067325592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3610289692878723},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14557793736457825},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.05326095223426819},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048113226890563965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393334005","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGZS200501001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764876134","display_name":"Chinese Journal of Osteoporosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316229","host_organization_name":"University of California, San Francisco","host_organization_lineage":["https://openalex.org/P4310316229","https://openalex.org/P4310316177"],"host_organization_lineage_names":["University of California, San Francisco","University of California"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Osteoporosis","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085755629","https://openalex.org/W2009566132","https://openalex.org/W2364819508","https://openalex.org/W2393319577","https://openalex.org/W2390439435","https://openalex.org/W3031262259","https://openalex.org/W1980855151","https://openalex.org/W2391555297","https://openalex.org/W2072050034","https://openalex.org/W2391690635"],"abstract_inverted_index":{"Objective":[0],"To":[1],"observe":[2],"the":[3,11,25,31,78,93,98,127,141,149,155,168],"effects":[4,112],"of":[5,13,28,33,38,64,80,95,100,107,129,144,151,170],"tumor":[6],"necrosis":[7],"factor-alpha":[8],"(TNF-\u03b1)":[9],"on":[10,97,113],"expressions":[12,37],"osteoprotegerin":[14],"(OPG)":[15],"in":[16,30,51,57,71,82,85,131,140,167],"mouse":[17],"bone":[18,120,123,132],"marrow":[19,133],"stromal":[20,134],"MBA-1":[21,135],"cells,":[22],"and":[23,41,48,60,122],"investigate":[24],"potential":[26],"roles":[27],"TNF-\u03b1":[29,56,76,96,117,163],"pathogenesis":[32],"osteoporosis.":[34],"Methods":[35],"The":[36,137],"OPG":[39,42,68,81,130,152,160],"mRNA":[40],"protein":[43],"was":[44,69],"assayed":[45],"by":[46,125,162],"RT-PCR":[47],"Western":[49],"blot":[50],"BMA-1":[52,72,83],"cells":[53,84],"treated":[54],"with":[55,148],"different":[58,62],"concentrations":[59],"at":[61],"time-periods":[63],"cultures.":[65],"Results":[66],"(1)":[67],"expressed":[70],"cell":[73],"lines.":[74],"(2)":[75],"downregulated":[77],"expression":[79,99,128,161],"a":[86],"dose-and":[87],"time-independent":[88],"manner.":[89],"(3)":[90],"17\u03b2-estradiol":[91],"suppressed":[92],"downregulation":[94],"OPG,":[101],"whereas":[102],"pyrrodine":[103],"dithiocarbamete":[104],"(PDTC)":[105],"(inhibitor":[106],"nuclear":[108,171],"factor-\u03baB)":[109],"had":[110],"no":[111],"its":[114],"downregulation.":[115],"Conclusions":[116],"enhances":[118],"osteoclastic":[119],"resorption":[121],"loss":[124],"decreasing":[126],"cells.":[136],"mechanism":[138],"involved":[139,166],"therapeutic":[142],"effect":[143],"estrogen":[145],"may":[146],"associate":[147],"suppression":[150],"expression,":[153],"but":[154],"signaling":[156],"pathway":[157],"that":[158],"regulates":[159],"is":[164],"not":[165],"activation":[169],"fcator-\u03baB.":[172]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
