{"id":"https://openalex.org/W2393112934","doi":"https://doi.org/10.2174/1381612822666151216151856","title":"The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery","display_name":"The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery","publication_year":2016,"publication_date":"2016-03-04","ids":{"openalex":"https://openalex.org/W2393112934","doi":"https://doi.org/10.2174/1381612822666151216151856","mag":"2393112934","pmid":"https://pubmed.ncbi.nlm.nih.gov/26675218"},"language":"en","primary_location":{"id":"doi:10.2174/1381612822666151216151856","doi":"https://doi.org/10.2174/1381612822666151216151856","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666151216151856","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024515621","display_name":"Carolyn T. Jordan","orcid":"https://orcid.org/0000-0002-1243-0038","observed_orcids":["https://orcid.org/0000-0002-1243-0038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Jordan","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038786186","display_name":"Vladimir V. Shuvaev","orcid":"https://orcid.org/0000-0003-2449-460X","observed_orcids":["https://orcid.org/0000-0003-2449-460X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir V. Shuvaev","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065702930","display_name":"Mark M. Bailey","orcid":"https://orcid.org/0000-0001-8950-1431","observed_orcids":["https://orcid.org/0000-0001-8950-1431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Bailey","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022924802","display_name":"Vladimir R. Muzykantov","orcid":"https://orcid.org/0000-0001-6648-1204","observed_orcids":["https://orcid.org/0000-0001-6648-1204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir R. Muzykantov","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051709163","display_name":"Thomas D. Dziubla","orcid":"https://orcid.org/0000-0003-2518-3926","observed_orcids":["https://orcid.org/0000-0003-2518-3926"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Dziubla","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506- 0046. dziubla@engr.uky.edu","Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506- 0046.,0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506- 0046. dziubla@engr.uky.edu","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506- 0046.,0","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3599,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75399672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"9","first_page":"1259","last_page":"1273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonspherical-particles","display_name":"non-spherical particles","score":0.5889999866485596},{"id":"https://openalex.org/keywords/rod-shaped-nanoparticles","display_name":"rod-shaped nanoparticles","score":0.6110000014305115},{"id":"https://openalex.org/keywords/nanodiamonds","display_name":"nanodiamonds","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.6179999709129333},{"id":"https://openalex.org/keywords/vascular-barrier","display_name":"vascular barrier","score":0.6690000295639038},{"id":"https://openalex.org/keywords/mucosal-barrier","display_name":"mucosal barrier","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9150000214576721},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.5009999871253967},{"id":"https://openalex.org/keywords/particle-shape-control","display_name":"particle shape control","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.8891487717628479},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.675966203212738},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6085065603256226},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5707073211669922},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.5284098386764526},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5192596912384033},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.46145308017730713},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.41248369216918945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3742724061012268},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3692273497581482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3400062918663025},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.320129930973053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.28997373580932617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22443222999572754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1992005705833435},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.1505117416381836},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.12385502457618713},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11475175619125366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612822666151216151856","doi":"https://doi.org/10.2174/1381612822666151216151856","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666151216151856","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:26675218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26675218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G192524536","display_name":null,"funder_award_id":"UL1TR00011","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2348514949","display_name":"Targeted nanomedicine for ALI and I/R","funder_award_id":"R01HL125462","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8290060235","display_name":"Targeting Carriers with Controlled Geometry to Endothelium","funder_award_id":"5r01hl087036-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G922908772","display_name":null,"funder_award_id":"R01-HL087036","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164711727","https://openalex.org/W1973690395","https://openalex.org/W3034251015","https://openalex.org/W4410697724","https://openalex.org/W2132019508","https://openalex.org/W4312117242","https://openalex.org/W2493857608","https://openalex.org/W7223374614","https://openalex.org/W2897785223","https://openalex.org/W7222842518"],"abstract_inverted_index":{"For":[0],"a":[1,191],"variety":[2],"of":[3,24,41,59,71,101,134,144,162,193],"diseases,":[4],"effective":[5],"therapy":[6],"is":[7],"severely":[8],"limited":[9],"or":[10,172],"rendered":[11],"impossible":[12],"due":[13,106],"to":[14,17,20,37,62,93,107,116,179,197],"an":[15],"inability":[16],"deliver":[18],"medications":[19],"the":[21,30,39,46,56,96,120,129,135,142,170,181,202],"intended":[22],"sites":[23],"action.":[25],"Multiple":[26],"barriers":[27],"exist":[28],"through":[29],"body,":[31],"which":[32],"have":[33,206],"evolved":[34],"over":[35],"time":[36],"limit":[38],"migration":[40],"foreign":[42],"compounds":[43],"from":[44],"entering":[45],"tissues.":[47],"Turning":[48],"toward":[49],"biology":[50],"as":[51,156],"inspiration,":[52],"it":[53,89,112],"has":[54,113],"been":[55],"general":[57],"goal":[58],"drug":[60,136,208],"delivery":[61],"create":[63],"carrier":[64,199],"strategies":[65],"that":[66,74],"mimic,":[67],"in":[68,109,141,174],"part,":[69],"features":[70],"bacteria/":[72],"viruses":[73],"allow":[75],"them":[76],"overcome":[77,180],"these":[78,204],"barriers.":[79,212],"By":[80],"packaging":[81],"drugs":[82],"into":[83],"nano":[84],"and":[85,98,132,151,158,164,177,183,201],"micron":[86],"scale":[87],"vehicles,":[88],"should":[90],"be":[91,167],"possible":[92,115],"completely":[94],"change":[95],"biodistribution":[97],"residence":[99],"times":[100],"pharmaceutically":[102],"active":[103],"compounds.":[104],"Recently,":[105],"advances":[108],"formulation":[110,143],"technologies,":[111],"become":[114],"control":[117,198],"not":[118],"just":[119],"material":[121],"selection,":[122],"surface":[123],"chemistry,":[124],"and/or":[125],"size,":[126],"but":[127],"also":[128,178],"overall":[130],"geometry":[131],"plasticity":[133],"carriers.":[137],"These":[138],"approaches":[139,195],"aid":[140,171],"nonspherical":[145],"particles":[146],"such":[147,155],"as,":[148],"discs,":[149],"rods,":[150],"even":[152],"unique":[153],"structures":[154],"cubes":[157],"nanodiamonds.":[159],"The":[160],"adjustment":[161],"size":[163],"shape":[165,200],"can":[166],"used":[168,196],"for":[169],"prevention":[173],"cellular":[175],"uptake":[176],"vascular":[182],"mucosal":[184],"barrier.":[185],"In":[186],"this":[187],"review,":[188],"we":[189],"present":[190],"summary":[192],"some":[194],"impact":[203],"geometries":[205],"upon":[207],"transport":[209],"across":[210],"biological":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
