{"id":"https://openalex.org/W2393072029","doi":null,"title":"Expression and significance of glucose regulated protein GRP78 in nonalcoholic steatohepatitis of rats","display_name":"Expression and significance of glucose regulated protein GRP78 in nonalcoholic steatohepatitis of rats","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2393072029","mag":"2393072029"},"language":"en","primary_location":{"id":"mag:2393072029","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-DSDX200901037.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500200","display_name":"Di-san junyi daxue xuebao","issn_l":"1000-5404","issn":["1000-5404"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-san junyi daxue xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lili Yan","orcid":"https://orcid.org/0000-0003-4491-1853","observed_orcids":["https://orcid.org/0000-0003-4491-1853"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lili Yan","raw_affiliation_strings":["Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China)"],"raw_orcid":"https://orcid.org/0000-0003-4491-1853","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China)","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43352963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.17260000109672546,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.8830000162124634},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fatty-diet","display_name":"fatty diet","score":0.7799999713897705},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5289999842643738},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.777999997138977},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9700000286102295},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.7459999918937683},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7429999709129333},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7869239449501038},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6847426295280457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6508142948150635},{"id":"https://openalex.org/C2780995651","wikidata":"https://www.wikidata.org/wiki/Q5572343","display_name":"Glucose-regulated protein","level":4,"score":0.6273422837257385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5956317186355591},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5323911905288696},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.48898398876190186},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.48113003373146057},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4514625370502472},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.4505305290222168},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.44128501415252686},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.42164647579193115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3924559950828552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38358020782470703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3555917739868164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2492407262325287},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.16819879412651062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09659144282341003},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0941472053527832},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2393072029","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-DSDX200901037.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500200","display_name":"Di-san junyi daxue xuebao","issn_l":"1000-5404","issn":["1000-5404"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-san junyi daxue xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2756784847","https://openalex.org/W3031101618","https://openalex.org/W2378556971","https://openalex.org/W2356979133","https://openalex.org/W2355967264","https://openalex.org/W2859667204","https://openalex.org/W4408246294","https://openalex.org/W2033810579","https://openalex.org/W2379250923","https://openalex.org/W2148478247"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,13,24,67,79,135],"expression":[4,63,97,119,129],"of":[5,26,32,37,64,84,91,98,120,130],"endoplasmic":[6,27,136],"reticulum":[7,28,137],"molecular":[8],"chaperone,glucose":[9],"regulated":[10],"protein":[11,101],"78(GRP78),in":[12],"liver":[14,68,89],"tissues":[15,57],"during":[16],"fatty":[17,43,54,126,142],"diet-induced":[18],"nonalcoholic":[19,33,38],"steatohepatitis(NASH)in":[20],"rats":[21],"and":[22,73,86,88,102],"explore":[23],"role":[25],"stress":[29],"in":[30,66,93,107,109,115,134,150],"pathogenesis":[31],"steatohepatitis.Methods":[34],"Rat":[35],"model":[36],"steatohepatitis":[39],"were":[40,46,58,95,105],"established":[41],"with":[42,71,78],"dieting.Blood":[44],"samples":[45],"collected":[47],"to":[48,60,141],"detect":[49],"serum":[50,82],"aspartate":[51],"transaminase(AST),alanine":[52],"aminotransferase(ALT),free":[53],"acid(FFA)and":[55],"triglyceride(TG).Liver":[56],"obtained":[59],"measure":[61],"malondialdehyde(MDA)content.The":[62],"GRP78":[65,99,121,131],"was":[69],"detected":[70],"RT-PCR":[72],"Western":[74],"blot":[75],"analysis.Results":[76],"Compared":[77],"control":[80],"group,the":[81],"contents":[83],"ALT,AST,FFA":[85],"TG":[87],"content":[90],"MDA":[92],"NASH":[94,108],"increased.The":[96],"at":[100],"gene":[103],"levels":[104],"increased":[106],"a":[110],"time-dependent":[111],"manner,and":[112],"reached":[113],"peak":[114],"16":[116],"weeks(P0.01).Conclusion":[117],"Enhanced":[118],"could":[122,132],"be":[123,147],"induced":[124],"by":[125],"diet.The":[127],"excessive":[128],"result":[133],"stress,and":[138],"thus":[139],"lead":[140],"acid":[143],"abnormal":[144],"deposition,which":[145],"might":[146],"closely":[148],"involved":[149],"NASH.":[151]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
