{"id":"https://openalex.org/W2392998271","doi":null,"title":"Pathological opening of blood-brain barrier in disease conditions","display_name":"Pathological opening of blood-brain barrier in disease conditions","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2392998271","mag":"2392998271"},"language":"en","primary_location":{"id":"mag:2392998271","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB200508022.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061163918","display_name":"Guo Rui-bing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guo Rui-bing","raw_affiliation_strings":[", LIU Xin-feng"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", LIU Xin-feng","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061163918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35508512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.9267400503158569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5894932150840759},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5358584523200989},{"id":"https://openalex.org/C2991673738","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Brain disease","level":3,"score":0.5294016599655151},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4641261100769043},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46033793687820435},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.45955052971839905},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4257451295852661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21138295531272888},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13921305537223816}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392998271","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB200508022.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W203987145","https://openalex.org/W2363255177","https://openalex.org/W2079603034","https://openalex.org/W3178437976","https://openalex.org/W101776455","https://openalex.org/W2954409548","https://openalex.org/W4385308165","https://openalex.org/W4409301489","https://openalex.org/W2325606720","https://openalex.org/W2167739272"],"abstract_inverted_index":{"Most":[0],"compounds":[1],"in":[2,25],"blood":[3],"are":[4,34,52],"blocked":[5],"from":[6],"flowing":[7],"into":[8],"brain":[9],"by":[10],"blood-brain":[11,46,55],"barrier(BBB)":[12],"to":[13,44,54,66],"keep":[14],"central":[15,70],"nerve":[16,71],"system":[17,72],"normal,":[18],"but":[19],"this":[20],"barrier":[21,47],"will":[22,41],"be":[23,64],"open":[24],"different":[26,29],"diseases":[27,50],"with":[28],"mechanisms.":[30],"As":[31],"these":[32],"mechanisms":[33],"understood":[35],"more":[36,38],"and":[37,48],"clearly,":[39],"it":[40,61],"do":[42],"help":[43],"protect":[45],"treat":[49],"which":[51],"correlative":[53],"barrier.":[56],"At":[57],"the":[58],"same":[59],"time,":[60],"may":[62],"also":[63],"helpful":[65],"let":[67],"drugs":[68],"entering":[69],"through":[73],"BBB.":[74]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}