{"id":"https://openalex.org/W2392907760","doi":null,"title":"Preclinical and Clinical Studies on Gene Therapy of Parkinson's Disease","display_name":"Preclinical and Clinical Studies on Gene Therapy of Parkinson's Disease","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2392907760","mag":"2392907760"},"language":"en","primary_location":{"id":"mag:2392907760","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JPKX200601019.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764639538","display_name":"Jiepou kexue jinzhan","issn_l":"1006-2947","issn":["1006-2947"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jiepou kexue jinzhan","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000867752","display_name":"Deyi Duan","orcid":"https://orcid.org/0000-0002-1857-3718","observed_orcids":["https://orcid.org/0000-0002-1857-3718"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deyi Duan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1857-3718","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000867752"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.27469998598098755,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":1.0},{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.7879999876022339},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"subthalamic nucleus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gaba-synthesis","display_name":"GABA synthesis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/thalamocortical-circuits","display_name":"thalamocortical circuits","score":0.6980000138282776},{"id":"https://openalex.org/keywords/globus-pallidus-internus","display_name":"globus pallidus internus","score":0.75},{"id":"https://openalex.org/keywords/substantia-nigra-pars-reticulata","display_name":"substantia nigra pars reticulata","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.972000002861023},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.7830183506011963},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.676101565361023},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.6575227379798889},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.6139510869979858},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5974778532981873},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5955536365509033},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5814520716667175},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5058417320251465},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.5001828670501709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42976611852645874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42954036593437195},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.42615365982055664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4117535948753357},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.3490448296070099},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3149033784866333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25689440965652466},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.25672170519828796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2267642319202423},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19745805859565735},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.16595381498336792},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1509348750114441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11199846863746643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11174055933952332},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.07768517732620239},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.048515498638153076},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392907760","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JPKX200601019.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764639538","display_name":"Jiepou kexue jinzhan","issn_l":"1006-2947","issn":["1006-2947"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Jiepou kexue jinzhan","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088346667","https://openalex.org/W2047258598","https://openalex.org/W181410918","https://openalex.org/W2076413927","https://openalex.org/W2145146973","https://openalex.org/W2047516655","https://openalex.org/W2951429658","https://openalex.org/W2057818077","https://openalex.org/W2468714401","https://openalex.org/W2094141041"],"abstract_inverted_index":{"Two":[0],"main":[1],"strategies":[2],"have":[3],"being":[4],"tested":[5],"in":[6,12,31,59],"pre-clinical":[7],"works":[8],"on":[9],"gene":[10,66],"therapy":[11],"a":[13,94],"nonhuman":[14],"primate":[15],"model":[16],"of":[17,21,45,52,79,96,99,101,107,121,127],"Parkinson\ue698s":[18,62],"disease,including":[19],"introduction":[20],"therapeutic":[22,128],"genes":[23],"such":[24],"as":[25],"dopamine-synthetic":[26],"enzymes":[27],"or":[28,33,47],"neurothophic":[29],"factors":[30],"vivo":[32,35],"ex":[34],"into":[36,73],"the":[37,42,50,53,74,80,87,90,97,108,112],"nigrostriatal":[38],"system":[39],"to":[40,48,118],"augment":[41],"striatal":[43],"level":[44],"dopamine":[46],"promote":[49],"survival":[51],"remaining":[54],"nigral":[55],"neuron.In":[56],"clinical":[57],"trials":[58],"humans":[60],"with":[61],"disease,glutamic":[63],"acid":[64],"decarboxylase":[65],"mediated":[67],"by":[68,86],"adeno-associated":[69],"virus":[70],"was":[71,84],"transduced":[72],"subthalamic":[75],"nucleus":[76],"where":[77],"synthesis":[78],"inhibitory":[81],"neurotransmitter":[82],"GABA":[83],"catalyzed":[85],"enzyme":[88],"from":[89],"excitory":[91],"glutamic":[92],"acid,as":[93],"result":[95],"inhibition":[98],"overactivity":[100],"its":[102],"terminal":[103],"regions(the":[104],"internal":[105],"segment":[106],"globus":[109],"pallidus":[110],"and":[111,125],"substantia":[113],"nigra":[114],"pars":[115],"reticulata),eventually":[116],"leading":[117],"marked":[119],"attenuation":[120],"over-inhibitory":[122],"thalamocortical":[123],"circuit":[124],"generation":[126],"benefit.":[129]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
