{"id":"https://openalex.org/W2392630663","doi":null,"title":"Effects of inhibitor of serine/threonine protein phosphatases 1 and 2A on voltage-dependent sodium channels in rat trigeminal ganglion neurons","display_name":"Effects of inhibitor of serine/threonine protein phosphatases 1 and 2A on voltage-dependent sodium channels in rat trigeminal ganglion neurons","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2392630663","mag":"2392630663"},"language":"en","primary_location":{"id":"mag:2392630663","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YLBS200504001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765063488","display_name":"Zhongguo yaolixue yu dulixue zazhi","issn_l":"1000-3002","issn":["1000-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4327904652","host_organization_name":"Chinese Journal of Pharmacology and Toxicology","host_organization_lineage":["https://openalex.org/P4327904652"],"host_organization_lineage_names":["Chinese Journal of Pharmacology and Toxicology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue yu dulixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007704039","display_name":"Xue Cao","orcid":"https://orcid.org/0000-0002-1303-9604","observed_orcids":["https://orcid.org/0000-0002-1303-9604","https://orcid.org/0009-0009-5639-5391"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xue Cao","raw_affiliation_strings":["-Hong~1, MING Zhang-Yin~1, FU Hui~1, PAN Jian-Ping~1, LIU Lie-Ju~1,2*"],"raw_orcid":"https://orcid.org/0000-0002-1303-9604","affiliations":[{"raw_affiliation_string":"-Hong~1, MING Zhang-Yin~1, FU Hui~1, PAN Jian-Ping~1, LIU Lie-Ju~1,2*","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007704039"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.222574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.7490000128746033},{"id":"https://openalex.org/keywords/serine-threonine-protein-phosphatase","display_name":"serine/threonine phosphatase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":1.0},{"id":"https://openalex.org/keywords/trigeminal-ganglion-neurons","display_name":"trigeminal ganglion neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tetrodotoxin-resistant-sodium-current","display_name":"tetrodotoxin-resistant sodium current","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sodium-channel-regulation","display_name":"sodium channel regulation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6320000290870667},{"id":"https://openalex.org/keywords/small-diameter-neurons","display_name":"small-diameter neurons","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.9552149772644043},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.6506866216659546},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6364537477493286},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5774748921394348},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.5534072518348694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5199331641197205},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5127997994422913},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5022070407867432},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4810512363910675},{"id":"https://openalex.org/C2776352249","wikidata":"https://www.wikidata.org/wiki/Q776972","display_name":"Trigeminal ganglion","level":3,"score":0.4807721972465515},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.45495787262916565},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4283679127693176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38999703526496887},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3687128722667694},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2936473488807678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.273942232131958},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1403195559978485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0972331166267395},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392630663","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YLBS200504001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765063488","display_name":"Zhongguo yaolixue yu dulixue zazhi","issn_l":"1000-3002","issn":["1000-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4327904652","host_organization_name":"Chinese Journal of Pharmacology and Toxicology","host_organization_lineage":["https://openalex.org/P4327904652"],"host_organization_lineage_names":["Chinese Journal of Pharmacology and Toxicology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue yu dulixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2350298173","https://openalex.org/W2016837051","https://openalex.org/W2029522143","https://openalex.org/W2055282849","https://openalex.org/W1967424746","https://openalex.org/W1980108537","https://openalex.org/W2169064772","https://openalex.org/W1972112989","https://openalex.org/W2073575798","https://openalex.org/W1519457709"],"abstract_inverted_index":{"AIM":[0],"To":[1],"investigate":[2],"the":[3,33,39,53,108,130],"role":[4],"of":[5,11,52,111,120,132],"serine/threonine":[6,54,124],"protein":[7,55,125],"phosphatases":[8,56,126],"in":[9,19,107,129],"regulation":[10,131],"cell":[12],"signal":[13],"transduction":[14],"on":[15,61,86,93,118,138],"voltage-dependent":[16],"sodium":[17,35,41,136,150],"channels":[18,137],"rat":[20,63,139],"trigeminal":[21],"ganglion":[22],"(TRG)":[23],"neurons.":[24,65,141],"METHODSWhole-cell":[25],"patch":[26],"clamp":[27],"techniques":[28],"were":[29],"used":[30],"to":[31,155],"record":[32],"total":[34,133],"current":[36,42],"(I\ue00cNa-T)":[37],"and":[38,45,58,77,134],"tetrodotoxin-resistant":[40],"(I\ue00cNa-TTX-R)":[43],"before":[44],"after":[46],"okadaic":[47,69,99,156],"acid,":[48],"a":[49],"potent":[50],"inhibitor":[51],"1":[57,67,97],"2A,":[59],"perfusion":[60],"adult":[62],"TRG":[64,140,145],"RESULTS":[66],"\u03bcmol\u00b7L~-1":[68,98],"acid":[70,100],"inhibited":[71],"I\ue00cNa-T":[72,87],"by":[73,79],"(20\u00b113)%":[74],"(n=9,":[75],"P0.05)":[76],"I\ue00cNa-TTX-R":[78,94],"(4\u00b13)%":[80],"(n=6,":[81],"P0.05),":[82],"respectively.":[83],"The":[84,123],"inhibition":[85],"was":[88],"significantly":[89],"greater":[90],"than":[91],"that":[92,119],"(P0.05).":[95],"Furthermore,":[96],"produced":[101],"significant":[102],"3-4":[103],"mV":[104],"hyperpolarizing":[105],"shifts":[106],"conductance-voltage":[109],"curves":[110],"I\ue00cNa-T,":[112],"while":[113],"it":[114],"had":[115],"no":[116],"effect":[117],"I\ue00cNa-TTX-R.":[121],"CONCLUSION":[122],"take":[127],"part":[128],"TTX-R":[135],"In":[142],"addition,":[143],"small-diameter":[144],"neurons":[146],"express":[147],"various":[148],"voltage-gated":[149],"channel":[151],"with":[152],"different":[153],"sensitivity":[154],"acid.":[157]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
