{"id":"https://openalex.org/W2392497817","doi":null,"title":"Synthesis of Genistein Sulfates and Effects of Genistein and its Sulfates on Proliferation of Breast Cancer Cells","display_name":"Synthesis of Genistein Sulfates and Effects of Genistein and its Sulfates on Proliferation of Breast Cancer Cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2392497817","mag":"2392497817"},"language":"en","primary_location":{"id":"mag:2392497817","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SZGY201102007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764554180","display_name":"Lishizhen Medicine and Materia Medica Research","issn_l":"1008-0805","issn":["1008-0805"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727481","host_organization_name":"Shizhen Journal of Traditional Chinese Medicine","host_organization_lineage":["https://openalex.org/P4361727481"],"host_organization_lineage_names":["Shizhen Journal of Traditional Chinese Medicine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Lishizhen Medicine and Materia Medica Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101010208","display_name":"Haiyan Xu","orcid":"https://orcid.org/0009-0002-8687-1538","observed_orcids":["https://orcid.org/0009-0002-8687-1538"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyan Xu","raw_affiliation_strings":["School of Pharmaceutical Engineering,Shenyang Pharmacological University,Shenyang 110016,China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Engineering,Shenyang Pharmacological University,Shenyang 110016,China)","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101010208"],"corresponding_institution_ids":["https://openalex.org/I103890011"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38366314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chlorosulfonic-acid","display_name":"chlorosulfonic acid","score":0.7179999947547913},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7379999756813049},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/isoflavone-derivatives","display_name":"isoflavone derivatives","score":0.6159999966621399},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.9967600703239441},{"id":"https://openalex.org/C2778343803","wikidata":"https://www.wikidata.org/wiki/Q172290","display_name":"Sulfate","level":2,"score":0.6558330059051514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6448622345924377},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.5503557920455933},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2200259268283844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17528632283210754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16676241159439087}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392497817","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SZGY201102007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764554180","display_name":"Lishizhen Medicine and Materia Medica Research","issn_l":"1008-0805","issn":["1008-0805"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727481","host_organization_name":"Shizhen Journal of Traditional Chinese Medicine","host_organization_lineage":["https://openalex.org/P4361727481"],"host_organization_lineage_names":["Shizhen Journal of Traditional Chinese Medicine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Lishizhen Medicine and Materia Medica Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031114505","https://openalex.org/W2356007374","https://openalex.org/W7099200093","https://openalex.org/W2382209454","https://openalex.org/W7095085159","https://openalex.org/W2171818686","https://openalex.org/W2352427118","https://openalex.org/W3026803412","https://openalex.org/W2392334717","https://openalex.org/W2348465764"],"abstract_inverted_index":{"Objective":[0],"To":[1],"design":[2],"and":[3,7,53,64],"synthesize":[4],"genistein":[5,34,44,69],"mono-sulfate":[6],"investigate":[8],"their":[9],"effects":[10],"on":[11],"proliferation":[12,71,81],"of":[13,23,33,43,57,72,85],"MCF-7":[14,73],"breast":[15,74],"cancer":[16,75],"cells.Methods":[17],"Genistein-7-sulfate":[18],"was":[19,28,38],"achieved":[20],"by":[21,48,62],"reaction":[22,32,42],"chlorosulfonic":[24,51],"acid":[25],"with":[26,35,45,50],"genistein-4\u2032-hexanate,which":[27],"synthesized":[29,39],"via":[30,40],"the":[31,41,80,83],"hexanoyl":[36],"chloride.Genistein-4\u2032-sulfate":[37],"benzoyl":[46],"chloride,followed":[47],"treatment":[49],"acid.Results":[52],"Conclusion":[54],"The":[55],"structures":[56],"target":[58],"compounds":[59],"were":[60],"identified":[61],"1H-NMR":[63],"MS.MTT":[65],"test":[66],"showed":[67],"that":[68],"induced":[70],"cells,while":[76],"its":[77],"sulfate":[78],"inhibited":[79],"at":[82],"concentration":[84],"4.5":[86],"mmol\u00b7L-1.":[87]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}