{"id":"https://openalex.org/W2392388850","doi":"https://doi.org/10.1080/02770903.2016.1188941","title":"Transferability of genome-wide associated loci for asthma in African Americans","display_name":"Transferability of genome-wide associated loci for asthma in African Americans","publication_year":2016,"publication_date":"2016-05-13","ids":{"openalex":"https://openalex.org/W2392388850","doi":"https://doi.org/10.1080/02770903.2016.1188941","mag":"2392388850","pmid":"https://pubmed.ncbi.nlm.nih.gov/27177148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300042"},"language":"en","primary_location":{"id":"doi:10.1080/02770903.2016.1188941","doi":"https://doi.org/10.1080/02770903.2016.1188941","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02770903.2016.1188941","pdf_url":null,"source":{"id":"https://openalex.org/S143944388","display_name":"Journal of Asthma","issn_l":"0277-0903","issn":["0277-0903","1532-4303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Asthma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111838827","display_name":"Mezbah U. Faruque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mezbah U. Faruque","raw_affiliation_strings":["National Human Genome Center, Howard University College of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Center, Howard University College of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084227548","display_name":"Guanjie Chen","orcid":"https://orcid.org/0000-0002-5745-5618","observed_orcids":["https://orcid.org/0000-0002-5745-5618"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanjie Chen","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091245464","display_name":"Ayo Priscille Doumatey","orcid":"https://orcid.org/0000-0001-9494-7710","observed_orcids":["https://orcid.org/0000-0001-9494-7710"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayo P. Doumatey","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038667880","display_name":"Jie Zhou","orcid":"https://orcid.org/0000-0003-3389-7515","observed_orcids":["https://orcid.org/0000-0003-3389-7515"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhou","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020654379","display_name":"Hanxia Huang","orcid":"https://orcid.org/0000-0002-1753-7053","observed_orcids":["https://orcid.org/0000-0002-1753-7053"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanxia Huang","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070829421","display_name":"Daniel Shriner","orcid":"https://orcid.org/0000-0003-1928-5520","observed_orcids":["https://orcid.org/0000-0003-1928-5520"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Shriner","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072089289","display_name":"Adebowale Adeyemo","orcid":"https://orcid.org/0000-0002-3105-3231","observed_orcids":["https://orcid.org/0000-0002-3105-3231"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adebowale A. Adeyemo","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083621501","display_name":"Charles N. Rotimi","orcid":"https://orcid.org/0000-0001-5759-053X","observed_orcids":["https://orcid.org/0000-0001-5759-053X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Rotimi","raw_affiliation_strings":["Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109470935","display_name":"Georgia M. Dunston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia M. Dunston","raw_affiliation_strings":["National Human Genome Center, Howard University College of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Center, Howard University College of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I137853757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111838827"],"corresponding_institution_ids":["https://openalex.org/I137853757"],"apc_list":null,"apc_paid":null,"fwci":2.1296,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86177597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.21879999339580536,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.7960000038146973},{"id":"https://openalex.org/keywords/genome-wide-association-study-loci","display_name":"genome-wide association study loci","score":0.6359999775886536},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9079999923706055},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.9739999771118164},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.847690224647522},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7105215787887573},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.648216962814331},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6267695426940918},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.5298796892166138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5026493072509766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4979686737060547},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48174381256103516},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46002498269081116},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42133766412734985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30207353830337524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19708505272865295},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.10648387670516968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0924757719039917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/02770903.2016.1188941","doi":"https://doi.org/10.1080/02770903.2016.1188941","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02770903.2016.1188941","pdf_url":null,"source":{"id":"https://openalex.org/S143944388","display_name":"Journal of Asthma","issn_l":"0277-0903","issn":["0277-0903","1532-4303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Asthma","raw_type":"journal-article"},{"id":"pmid:27177148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27177148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of asthma : official journal of the Association for the Care of Asthma","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5300042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Asthma","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/3380941","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Transferability_of_genome_wide_associated_loci_for_asthma_in_African_Americans/3380941","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.3380941.v1","doi":"https://doi.org/10.6084/m9.figshare.3380941.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.3380941.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5300042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5300042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Asthma","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1600666550","display_name":"The Howard University SCORE Program","funder_award_id":"S06GM008016","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4481490527","display_name":"Computational Biology, Bioinformatics, Imaging & Proteomics Research-RCMI","funder_award_id":"G12RR003048","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G497772722","display_name":"Howard University General Clinical Research Center","funder_award_id":"M01RR010284","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6848686523","display_name":"Genetic epidemiology of complex diseases","funder_award_id":"Z01HG200362","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7852896272","display_name":"Biomedical Infrastructure for Health Disparities Research","funder_award_id":"G12MD007597","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W40378025","https://openalex.org/W1575966267","https://openalex.org/W1747499909","https://openalex.org/W1808276465","https://openalex.org/W1972372146","https://openalex.org/W1972465314","https://openalex.org/W1978580001","https://openalex.org/W1980991473","https://openalex.org/W1982042604","https://openalex.org/W1984764660","https://openalex.org/W1986265706","https://openalex.org/W1991262083","https://openalex.org/W1998641738","https://openalex.org/W2002046811","https://openalex.org/W2002395285","https://openalex.org/W2012067088","https://openalex.org/W2019966611","https://openalex.org/W2022458565","https://openalex.org/W2026859435","https://openalex.org/W2028543097","https://openalex.org/W2029857463","https://openalex.org/W2033038444","https://openalex.org/W2047729549","https://openalex.org/W2054618048","https://openalex.org/W2063097062","https://openalex.org/W2067225141","https://openalex.org/W2067964903","https://openalex.org/W2078050848","https://openalex.org/W2080725704","https://openalex.org/W2086702905","https://openalex.org/W2086807682","https://openalex.org/W2095224796","https://openalex.org/W2099745916","https://openalex.org/W2104486572","https://openalex.org/W2104775278","https://openalex.org/W2107766358","https://openalex.org/W2108707328","https://openalex.org/W2117371360","https://openalex.org/W2120483845","https://openalex.org/W2121686426","https://openalex.org/W2133739312","https://openalex.org/W2140026462","https://openalex.org/W2140968934","https://openalex.org/W2142243300","https://openalex.org/W2143110890","https://openalex.org/W2144856997","https://openalex.org/W2145269787","https://openalex.org/W2157710399","https://openalex.org/W2157752701","https://openalex.org/W2158206794","https://openalex.org/W2161633633","https://openalex.org/W2170645885","https://openalex.org/W2185196942","https://openalex.org/W2599911490"],"related_works":["https://openalex.org/W2061890918","https://openalex.org/W2591652961","https://openalex.org/W2104775278","https://openalex.org/W2917444392","https://openalex.org/W4294958201","https://openalex.org/W2493266901","https://openalex.org/W2144167897","https://openalex.org/W2089675595","https://openalex.org/W2133739312","https://openalex.org/W1918131333"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Transferability":[1],"of":[2,26,28,118,177,208,232,239,249,255],"significantly":[3,211],"associated":[4,63,143,212],"loci":[5,181,187,224],"or":[6],"GWAS":[7,67],"\"hits\"":[8],"adds":[9],"credibility":[10],"to":[11,61],"genotype-disease":[12],"associations":[13],"and":[14,48,157,172,189,195],"provides":[15],"evidence":[16,25],"for":[17,70,128,133],"generalizability":[18,254],"across":[19],"different":[20],"ancestral":[21],"populations.":[22],"We":[23,72],"sought":[24],"association":[27,183],"known":[29],"asthma-associated":[30,223,234],"single":[31],"nucleotide":[32],"polymorphisms":[33],"(SNPs)":[34],"in":[35,110,202,225,236,246],"an":[36,80,226],"African":[37,228],"American":[38,229],"population.":[39,230],"METHODS:":[40],"Subjects":[41],"comprised":[42],"661":[43],"participants":[44],"(261":[45],"asthma":[46,65],"cases":[47],"400":[49],"controls)":[50],"from":[51],"the":[52,87,107,113,119,178,237,240,253],"Howard":[53],"University":[54],"Family":[55],"Study.":[56],"Forty-eight":[57],"SNPs":[58,94,109,139,201,235],"previously":[59,244],"reported":[60,88,222],"be":[62],"with":[64,112,144,204,213],"by":[66,77],"were":[68,131,140,210],"selected":[69],"testing.":[71],"adopted":[73],"a":[74,101,242],"combined":[75],"strategy":[76],"first":[78],"adopting":[79],"\"exact\"":[81],"approach":[82,103],"where":[83],"we":[84,99],"looked-up":[85],"only":[86],"index":[89,93,114],"SNP.":[90,115],"For":[91],"those":[92],"missing":[95],"form":[96],"our":[97,122],"dataset,":[98],"used":[100],"\"local\"":[102],"that":[104],"examined":[105,132],"all":[106],"regional":[108],"LD":[111,203],"RESULTS:":[116],"Out":[117],"48":[120],"SNPs,":[121],"cohort":[123],"had":[124],"genotype":[125],"data":[126],"available":[127],"27,":[129],"which":[130],"exact":[134],"replication.":[135],"Of":[136,198],"these,":[137],"two":[138,185],"found":[141],"positively":[142],"asthma.":[145,214],"These":[146],"included:":[147],"rs10508372":[148],"(OR":[149,159],"=":[150,155,160,165],"1.567":[151],"[95%CI,":[152,162],"1.133-2.167],":[153],"P":[154,164,192],"0.0066)":[156],"rs2378383":[158],"2.147":[161],"1.149-4.013],":[163],"0.0166),":[166],"located":[167,206],"on":[168],"chromosomal":[169,186],"bands":[170],"10p14":[171],"9q21.31,":[173],"respectively.":[174],"Local":[175],"replication":[176],"remaining":[179],"21":[180],"showed":[182],"at":[184],"(9p24.1-rs2381413":[188],"6p21.32-rs3132947;":[190],"Bonferroni-corrected":[191],"values:":[193],"0.0033":[194],"0.0197,":[196],"respectively).":[197],"note,":[199],"multiple":[200],"rs2381413":[205],"upstream":[207,238],"IL33":[209],"CONCLUSIONS:":[215],"This":[216],"study":[217],"has":[218],"successfully":[219],"transferred":[220],"four":[221],"independent":[227],"Identification":[231],"several":[233],"IL33,":[241],"gene":[243],"implicated":[245],"allergic":[247],"inflammation":[248],"asthmatic":[250],"airway,":[251],"supports":[252],"this":[256],"finding.":[257]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}