{"id":"https://openalex.org/W2392322390","doi":null,"title":"[Early apoptosis of HL-60 cells induced by anti-CD44 McAb A3D8 inhibiting ERK1/2-upregulated Bim expression].","display_name":"[Early apoptosis of HL-60 cells induced by anti-CD44 McAb A3D8 inhibiting ERK1/2-upregulated Bim expression].","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2392322390","mag":"2392322390","pmid":"https://pubmed.ncbi.nlm.nih.gov/21729544"},"language":"zh","primary_location":{"id":"pmid:21729544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018474832","display_name":"Guoqiang Chang","orcid":"https://orcid.org/0000-0003-0308-971X","observed_orcids":["https://orcid.org/0000-0003-0308-971X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]},{"id":"https://openalex.org/I4391768267","display_name":"State Key Laboratory of Experimental Hematology","ror":"https://ror.org/0093mkr06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768267"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Qiang Chang","raw_affiliation_strings":["State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887","https://openalex.org/I4391768267"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090642719","display_name":"Wei Gao","orcid":"https://orcid.org/0000-0003-3081-9642","observed_orcids":["https://orcid.org/0000-0003-3081-9642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046370301","display_name":"Ruo-Jun Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruo-Jun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443576","display_name":"Lihong Wang","orcid":"https://orcid.org/0000-0002-6715-2944","observed_orcids":["https://orcid.org/0000-0002-6715-2944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Hong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101486098","display_name":"Wei\u2010Na Jin","orcid":"https://orcid.org/0000-0002-2196-9078","observed_orcids":["https://orcid.org/0000-0002-2196-9078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Na Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100869324","display_name":"Yani Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Ni Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hua-Wen Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua-Wen Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103279358","display_name":"Tianxiang Pang","orcid":"https://orcid.org/0000-0003-0792-4639","observed_orcids":["https://orcid.org/0000-0003-0792-4639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tian-Xiang Pang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.24958363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"3","first_page":"656","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8740000128746033},{"id":"https://openalex.org/keywords/apoptosis-inducing-factor","display_name":"apoptosis-inducing factor","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7776087522506714},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7277584075927734},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6967383027076721},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6620018482208252},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5952228307723999},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5734696388244629},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5392121076583862},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5059086680412292},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.47371524572372437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4660177528858185},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4211432933807373},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3851199150085449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359594941139221},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2455274760723114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09772700071334839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04905128479003906}],"mesh":[{"descriptor_ui":"D000072224","descriptor_name":"Bcl-2-Like Protein 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21729544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},{"id":"mag:2392322390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W977812385","https://openalex.org/W2418220158","https://openalex.org/W2539451155","https://openalex.org/W2355824184","https://openalex.org/W2350028519","https://openalex.org/W2039974697","https://openalex.org/W2059209427","https://openalex.org/W1554079934","https://openalex.org/W1541498995","https://openalex.org/W1988785438"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,41,55,65,73,116,131,142],"aimed":[3],"to":[4,19,75],"investigate":[5],"the":[6,21,32,37,46,77,91,95,122,126,140,148,159,163,173],"effects":[7],"of":[8,16,23,31,48,52,63,80,94,129,139,147,165,169,175],"anti-CD44":[9,33,154],"mAb":[10,34,86,155],"A3D8":[11,35,87,113,156],"on":[12,36],"proliferation":[13,40,92,160],"and":[14,25,101,161],"apoptosis":[15,164],"AML":[17],"cells,":[18,167],"explore":[20],"mechanism":[22,168],"ERK1/2":[24],"Bim":[26,64,130,176],"in":[27,98,108,136],"this":[28],"process.":[29],"Effect":[30],"HL-60":[38,53,96,109,166],"cell":[39],"assayed":[42],"with":[43,112,121],"MTT":[44],"method,":[45],"change":[47],"mitochondrial":[49,105],"transmembrane":[50,106],"potential":[51,107],"cells":[54,97,110],"analyzed":[56],"by":[57,67],"flow":[58],"cytometry.":[59],"The":[60,82,104],"mRNA":[61,127],"expression":[62,79,128,174],"determined":[66],"real-time":[68],"quantitative":[69],"RT-PCR.":[70],"Western":[71],"blot":[72],"used":[74],"detect":[76],"protein":[78],"p-ERK1/2.":[81,179],"results":[83],"showed":[84],"that":[85,135,146,153],"could":[88],"remarkably":[89],"inhibit":[90,158],"capacity":[93],"a":[99],"dosage-":[100],"time-dependent":[102],"ways.":[103],"treated":[111],"(3.0":[114],"\u00b5g/ml)":[115],"significantly":[117],"decreased":[118],"as":[119],"compared":[120],"control":[123],"cells.":[124],"Furthermore,":[125],"much":[132,143],"higher":[133],"than":[134,145],"controls.":[137,149],"Expression":[138],"p-ERK":[141],"lower":[144],"It":[150],"is":[151,171],"concluded":[152],"can":[157],"induce":[162],"which":[170],"enhancing":[172],"via":[177],"inhibiting":[178]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
