{"id":"https://openalex.org/W2392298985","doi":null,"title":"Cerebrospinal fluid biomarkers for early diagnosis of Alzheimer disease","display_name":"Cerebrospinal fluid biomarkers for early diagnosis of Alzheimer disease","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2392298985","mag":"2392298985"},"language":"en","primary_location":{"id":"mag:2392298985","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZSJJ201111013.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764400384","display_name":"Zhongguo shenjing jingshen jibing zazhi","issn_l":"1002-0152","issn":["1002-0152"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shenjing jingshen jibing zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042346254","display_name":"Sun Yingz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sun Yingz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042346254"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34824179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.12729999423027039,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8320000171661377},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.9139691591262817},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6544240713119507},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.5851249694824219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5843149423599243},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5368787050247192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47575587034225464},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4748009741306305},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.45639723539352417},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43838179111480713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3794165849685669},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34209662675857544}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392298985","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZSJJ201111013.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764400384","display_name":"Zhongguo shenjing jingshen jibing zazhi","issn_l":"1002-0152","issn":["1002-0152"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shenjing jingshen jibing zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2369016853","https://openalex.org/W2361783169","https://openalex.org/W2382103515","https://openalex.org/W2083306232","https://openalex.org/W2356180376","https://openalex.org/W2617620511","https://openalex.org/W2073030553","https://openalex.org/W20177886","https://openalex.org/W2009075080","https://openalex.org/W2171997215"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,14,79,108,129],"cerebrospinal":[4],"fluid(CSF)":[5],"levels":[6,45,58,91],"of":[7,46,59,92,131],"tau":[8,47,60,123],"protein":[9,48,61,121,124],"and":[10,19,32,40,49,83,112,122,136,144],"\u03b2-amyloid":[11],"peptide1-42(A\u03b21-42)":[12],"in":[13,66,72,77,97,101,106],"patients":[15,29,36],"with":[16,30,37,53,133],"Alzheimer":[17],"disease(AD)":[18],"their":[20],"diagnosetic":[21],"value":[22],"for":[23,128],"AD.Methods":[24],"The":[25,55],"subjects":[26],"were":[27,51],"36":[28],"AD":[31,67,82,111,132,143],"26":[33,41],"controls,includeing":[34],"24":[35],"vascular":[38],"dementia(VD)":[39],"normal":[42],"controls(NC).The":[43],"CSF":[44,57,90],"A\u03b21-42":[50,93],"measured":[52],"ELISA.Results":[54],"mean":[56,89],"were(336":[62],"\u00b1":[63,69,74,95,99,103],"126)":[64],"ng/L":[65,71,76,105],"patients,(183":[68],"96)":[70],"VD,and(98":[73],"54)":[75],"NC,respectively,and":[78],"difference":[80],"between":[81,110],"NC":[84,113],"was":[85,114],"statistically":[86,115],"significant(P":[87,116],"0.05).The":[88],"were(341":[94],"113)ng/L":[96],"AD,(457":[98],"132)ng/L":[100],"VD,and(502":[102],"167)":[104],"NC,and":[107],"differentce":[109],"0.05).Conclusions":[117],"Cerebrospinal":[118],"fluid":[119],"A\u03b21-42,tau":[120],"are":[125],"useful":[126],"biomarkers":[127],"diagnosis":[130],"high":[134],"sensitivity":[135],"specificity,and":[137],"can":[138],"be":[139],"used":[140],"to":[141],"differentiate":[142],"VD.":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
