{"id":"https://openalex.org/W2392233710","doi":null,"title":"The generation and verification of an adeno-associated virus vector using a hypoxic response element promoter to control the expression of human-VEGF_(165)","display_name":"The generation and verification of an adeno-associated virus vector using a hypoxic response element promoter to control the expression of human-VEGF_(165)","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2392233710","mag":"2392233710"},"language":"en","primary_location":{"id":"mag:2392233710","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XZYX200702001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500209","display_name":"Acta Academiae Medicinae Xuzhou","issn_l":"2096-3882","issn":["2096-3882"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Academiae Medicinae Xuzhou","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100965233","display_name":"Dong Hongyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Hongyan","raw_affiliation_strings":["Rearch Center of Neurobiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rearch Center of Neurobiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002)","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100965233"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28545878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vegf165","display_name":"VEGF165","score":0.9309999942779541},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.8126896619796753},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.686772882938385},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5859084129333496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5804758071899414},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5154083967208862},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.507084846496582},{"id":"https://openalex.org/C33161422","wikidata":"https://www.wikidata.org/wiki/Q5421712","display_name":"Expression vector","level":4,"score":0.49403315782546997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4707183241844177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3813523054122925},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35539510846138},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2621816396713257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15541791915893555}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2392233710","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XZYX200702001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500209","display_name":"Acta Academiae Medicinae Xuzhou","issn_l":"2096-3882","issn":["2096-3882"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Academiae Medicinae Xuzhou","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2364284919","https://openalex.org/W2048778950","https://openalex.org/W2391257822","https://openalex.org/W2349049433","https://openalex.org/W2358178583","https://openalex.org/W2392427552","https://openalex.org/W2381506933","https://openalex.org/W2022700657","https://openalex.org/W2094146162","https://openalex.org/W2399690963"],"abstract_inverted_index":{"Objective":[0],"To":[1],"generate":[2],"and":[3,54,63,120],"identify":[4],"an":[5],"AAV-VEGF165vector":[6],"using":[7,24],"a":[8,115],"hypoxic":[9],"response":[10,117,141],"element":[11,118],"promoter":[12],"to":[13,84,129,142],"control":[14],"the":[15,25,121,137,143],"expression":[16,68,94],"of":[17,69,79,86,95,145],"hVEGF165.Methods":[18],"AVV":[19],"vectors":[20],"were":[21,57],"prepared":[22],"by":[23,40,90],"three-plasmid":[26],"cotransfection":[27],"system.The":[28],"AAV":[29,47,52],"vector":[30,48],"was":[31,72,82,99,113],"cotransfected":[32],"with":[33,65,74],"two":[34],"helper":[35],"plasmids":[36],"into":[37],"HEK293T":[38],"cells":[39],"calcium":[41],"phosphate":[42],"method,where":[43],"one":[44],"helper(pAAV-RC)":[45],"mediates":[46],"replication,the":[49],"other(pHelper)":[50],"has":[51],"rep":[53],"cap":[55],"genes.Myocardiocytes":[56],"isolated":[58],"from":[59],"neonatal":[60],"mouse":[61],"hearts":[62],"infected":[64],"AAV-HRE9-VEGF165":[66,81],"vector.The":[67],"hVEGF165":[70,96],"protein":[71],"shown":[73],"immunofluorescence.Results":[75],"The":[76],"sequence":[77],"result":[78],"plasmid":[80],"identical":[83],"that":[85],"human":[87],"VEGF165":[88],"published":[89],"NCBI":[91],"in":[92,97,140],"GenBanK.The":[93],"myocardiocytes":[98,128],"elicited":[100],"under":[101,105],"anoxic":[102],"condition,but":[103],"not":[104],"normal":[106],"non-anoxic":[107],"condition.Conclusion":[108],"An":[109],"adeno-associated":[110],"virus":[111],"vector(rAAV)":[112],"generated,containing":[114],"HRE(hypoxic":[116],"promotor)":[119],"objective":[122,131,138],"gene":[123,139],"VEGF165.The":[124],"rAAV":[125],"could":[126,134],"infect":[127],"transfer":[130],"gene,and":[132],"HRE9":[133],"timely":[135],"regulate":[136],"condition":[144],"myocardial":[146],"ischemia.":[147]},"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-06-24T00:00:00"}
