{"id":"https://openalex.org/W2391817478","doi":null,"title":"[Study on the expression of E2 gene of classical swine fever virus in Pichia pastoris and the immunological activity of its expression product].","display_name":"[Study on the expression of E2 gene of classical swine fever virus in Pichia pastoris and the immunological activity of its expression product].","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2391817478","mag":"2391817478","pmid":"https://pubmed.ncbi.nlm.nih.gov/12148285"},"language":"zh","primary_location":{"id":"pmid:12148285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12148285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101018555","display_name":"Han Xue-qing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090981","display_name":"Lanzhou Veterinary Research Institute","ror":"https://ror.org/00dg3j745","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090981","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-Qing Han","raw_affiliation_strings":["Lanzhou Veterinary Research Institute, CAS, Lanzhou 730046, China. hanxq8@hotmail.com","Lanzhou Veterinary Research Institute, CAS, Lanzhou 730046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lanzhou Veterinary Research Institute, CAS, Lanzhou 730046, China. hanxq8@hotmail.com","institution_ids":["https://openalex.org/I4210090981"]},{"raw_affiliation_string":"Lanzhou Veterinary Research Institute, CAS, Lanzhou 730046, China","institution_ids":["https://openalex.org/I4210090981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103217701","display_name":"Xiangtao Liu","orcid":"https://orcid.org/0000-0003-1813-1845","observed_orcids":["https://orcid.org/0000-0003-1813-1845"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang-Tao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007650371","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0001-6316-2734","observed_orcids":["https://orcid.org/0000-0001-6316-2734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112128114","display_name":"Xie Qing-ge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-Ge Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100588294","display_name":"Bo Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44189944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"2","first_page":"208","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.35690000653266907,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-swine-fever-virus","display_name":"classical swine fever virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/e2-glycoprotein","display_name":"E2 glycoprotein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/komagataella-phaffii","display_name":"Pichia pastoris","score":0.9440000057220459},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ppic9k-vector","display_name":"pPIC9K vector","score":0.8009999990463257},{"id":"https://openalex.org/keywords/secretory-expression","display_name":"secretory expression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2781372317","wikidata":"https://www.wikidata.org/wiki/Q148697","display_name":"Pichia pastoris","level":4,"score":0.9893907308578491},{"id":"https://openalex.org/C2779005923","wikidata":"https://www.wikidata.org/wiki/Q683770","display_name":"Classical swine fever","level":3,"score":0.7027996182441711},{"id":"https://openalex.org/C2779703480","wikidata":"https://www.wikidata.org/wiki/Q125153","display_name":"Pichia","level":5,"score":0.6188821196556091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6003496646881104},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.5438171029090881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5431491732597351},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5080711841583252},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5029050707817078},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4778687357902527},{"id":"https://openalex.org/C33161422","wikidata":"https://www.wikidata.org/wiki/Q5421712","display_name":"Expression vector","level":4,"score":0.469793438911438},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46282488107681274},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42644545435905457},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41994529962539673},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3336145281791687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12402454018592834}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010843","descriptor_name":"Pichia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12148285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12148285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"},{"id":"mag:2391817478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12148285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2367138128","https://openalex.org/W2988865106","https://openalex.org/W2388159173","https://openalex.org/W2362370792","https://openalex.org/W1973014882","https://openalex.org/W2365667583","https://openalex.org/W2381282359","https://openalex.org/W2353683680","https://openalex.org/W1999100098","https://openalex.org/W2944391643"],"abstract_inverted_index":{"E2":[0,85],"gene":[1],"of":[2,54,63,74],"classical":[3],"swine":[4],"fever":[5],"virus":[6],"(CSFV)":[7],"was":[8,24],"cloned":[9],"into":[10,26],"secretory":[11],"pPIC9K":[12],"Pichia":[13,27],"pastoris":[14,28,67,89],"expression":[15],"vector.":[16],"After":[17],"being":[18],"linearized":[19],"by":[20,29,43],"digestion,":[21],"the":[22,34,36,61,64,75,78,83],"vector":[23],"transformed":[25],"electroporation":[30],"to":[31,48,94],"integrate":[32],"with":[33,38,50],"genome,":[35],"transformants":[37],"high":[39],"copies":[40],"were":[41,46],"screened":[42],"G418":[44],"and":[45,56],"induced":[47,65],"express":[49],"methonal.":[51],"The":[52,72],"results":[53,73],"SDS-PAGE":[55],"Western":[57],"blot":[58],"demonstrated":[59],"that":[60,82],"supernatant":[62],"P.":[66,88],"culture":[68],"contained":[69],"protein":[70,84,98],"E2.":[71,99],"study":[76],"on":[77],"immunological":[79],"activity":[80],"indicated":[81],"expressed":[86],"in":[87],"can":[90],"elicit":[91],"animal":[92],"bodies":[93],"produce":[95],"antibodies":[96],"against":[97]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
