{"id":"https://openalex.org/W2391808993","doi":"https://doi.org/10.2310/6650.2002.32964","title":"Iron Transport and Hemochromatosis","display_name":"Iron Transport and Hemochromatosis","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2391808993","doi":"https://doi.org/10.2310/6650.2002.32964","mag":"2391808993","pmid":"https://pubmed.ncbi.nlm.nih.gov/12227653"},"language":"en","primary_location":{"id":"doi:10.2310/6650.2002.32964","doi":"https://doi.org/10.2310/6650.2002.32964","is_oa":false,"landing_page_url":"https://doi.org/10.2310/6650.2002.32964","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass","PhD, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Room 570, Boston, MA 02115. Email: mhediger{at}rics.bwh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"PhD, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Room 570, Boston, MA 02115. Email: mhediger{at}rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015001048","display_name":"Andreas Rolfs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Rolfs","raw_affiliation_strings":["From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051139835","display_name":"Tapasree Goswami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tapasree Goswami","raw_affiliation_strings":["From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078842111"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.1065,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.13488372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"50","issue":"5_suppl","first_page":"239","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-transport","display_name":"iron transport","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hemochromatosis","display_name":"hemochromatosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.656000018119812},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":1.0},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.6290000081062317},{"id":"https://openalex.org/keywords/iron-transport-proteins","display_name":"iron transport proteins","score":0.6499999761581421},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.527999997138977},{"id":"https://openalex.org/keywords/iron-storage","display_name":"iron storage","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.8879963159561157},{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.5843585133552551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4570406377315521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3446228504180908},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3205568194389343}],"mesh":[{"descriptor_ui":"D000099236","descriptor_name":"Solute Carrier Family 11, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033862","descriptor_name":"Iron-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2310/6650.2002.32964","doi":"https://doi.org/10.2310/6650.2002.32964","is_oa":false,"landing_page_url":"https://doi.org/10.2310/6650.2002.32964","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},{"id":"pmid:12227653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12227653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W130498243","https://openalex.org/W140882671","https://openalex.org/W153121858","https://openalex.org/W165130051","https://openalex.org/W195099397","https://openalex.org/W284603049","https://openalex.org/W1522974031","https://openalex.org/W1535178570","https://openalex.org/W1547673256","https://openalex.org/W1568628619","https://openalex.org/W1618001767","https://openalex.org/W1761222131","https://openalex.org/W1964569214","https://openalex.org/W1971455039","https://openalex.org/W2002605005","https://openalex.org/W2002986792","https://openalex.org/W2003152099","https://openalex.org/W2011898265","https://openalex.org/W2014193066","https://openalex.org/W2016821205","https://openalex.org/W2019757220","https://openalex.org/W2027810203","https://openalex.org/W2038944724","https://openalex.org/W2055667111","https://openalex.org/W2063617352","https://openalex.org/W2064997579","https://openalex.org/W2070236309","https://openalex.org/W2080638597","https://openalex.org/W2082806735","https://openalex.org/W2089161230","https://openalex.org/W2090165219","https://openalex.org/W2090401018","https://openalex.org/W2090868713","https://openalex.org/W2091028002","https://openalex.org/W2104657893","https://openalex.org/W2105749655","https://openalex.org/W2105923433","https://openalex.org/W2120579517","https://openalex.org/W2132544275","https://openalex.org/W2132863560","https://openalex.org/W2137143414","https://openalex.org/W2140816381","https://openalex.org/W2143716524","https://openalex.org/W2143900678","https://openalex.org/W2146213816","https://openalex.org/W2161998284","https://openalex.org/W2241306362","https://openalex.org/W2341885160","https://openalex.org/W4247812601"],"related_works":["https://openalex.org/W1989770058","https://openalex.org/W2479357922","https://openalex.org/W2056046882","https://openalex.org/W4236237125","https://openalex.org/W277418774","https://openalex.org/W1771468121","https://openalex.org/W2077350876","https://openalex.org/W4413042267","https://openalex.org/W2120035563","https://openalex.org/W70647745"],"abstract_inverted_index":{"Iron":[0,52,135],"is":[1,9,44,53,149,155],"vital":[2],"for":[3,76],"all":[4],"processes":[5],"of":[6,15,23,37,48,58,62,82,104,127,169,173,189,213,224,241,253,257,278,282,287],"life.":[7],"It":[8,27],"the":[10,16,35,56,59,66,79,89,102,114,125,137,151,163,235,258,276,279],"fourth":[11],"most":[12,146],"abundant":[13],"element":[14],"Earth's":[17],"crust":[18],"and":[19,39,41,69,116,120,129,166,177,187,205,227,250],"a":[20,72,171,192,238,263],"crucial":[21,215],"component":[22],"countless":[24],"biochemical":[25],"pathways.":[26],"can":[28,100,121],"readily":[29],"accept":[30],"or":[31],"donate":[32],"electrons":[33],"during":[34],"interconversion":[36],"Fe3+":[38,152],"Fe2+,":[40],"this":[42,214],"property":[43],"fundamental":[45],"to":[46,55,92,124,182,199,209,271],"many":[47],"its":[49],"biological":[50],"roles.":[51],"integral":[54],"catalysis":[57],"redox":[60],"reactions":[61,119],"oxidative":[63],"phosphorylation":[64],"in":[65,78,88,136,150,191,206,261,275],"respiratory":[67],"chain,":[68],"it":[70,267],"provides":[71],"specific":[73],"binding":[74],"site":[75],"oxygen":[77,86],"heme-binding":[80],"moiety":[81],"hemoglobin,":[83],"which":[84,154],"allows":[85],"transport":[87,175],"blood.\n\nIn":[90],"contrast":[91],"these":[93,202,225],"beneficial":[94],"features,":[95],"unless":[96],"appropriately":[97],"chelated,":[98],"iron":[99,148,190,246,248,254,283,288,290],"catalyze":[101],"formation":[103],"highly":[105],"reactive":[106],"toxic":[107],"compounds,":[108],"such":[109],"as":[110],"hydroxyl":[111],"radicals,":[112],"via":[113],"Fenton":[115],"Haber-Weiss":[117],"disproportionating":[118],"thereby":[122],"lead":[123],"damage":[126],"DNA":[128],"proteins":[130,179,203,226],"and,":[131],"hence,":[132],"cellular":[133,211],"destruction.":[134],"body":[138],"must":[139],"therefore":[140],"be":[141],"very":[142,218],"carefully":[143],"regulated.":[144],"Furthermore,":[145],"environmental":[147],"state,":[153],"almost":[156],"insoluble":[157],"at":[158],"neutral":[159],"pH.":[160],"To":[161],"overcome":[162],"virtual":[164],"insolubility":[165],"potential":[167],"toxicity":[168],"iron,":[170],"myriad":[172],"specialized":[174],"systems":[176],"associated":[178,244],"have":[180],"evolved":[181],"mediate":[183],"regulated":[184],"acquisition,":[185],"transport,":[186],"storage":[188],"nontoxic":[193],"way.":[194],"We":[195],"are":[196,230],"gradually":[197],"beginning":[198],"understand":[200],"how":[201],"individually":[204],"concert":[207],"serve":[208],"maintain":[210],"homeostasis":[212],"yet":[216],"potentially":[217],"harmful":[219],"metal":[220],"ion.":[221],"Recent":[222],"studies":[223],"their":[228],"functions":[229],"shedding":[231],"new":[232],"light":[233],"on":[234],"mechanisms":[236,281],"underlying":[237],"wide":[239],"range":[240],"human":[242],"diseases":[243],"with":[245],"deficiency,":[247,289],"overload,":[249,291],"other":[251],"imbalances":[252],"metabolism.\n\nThe":[255],"cloning":[256],"transferrin":[259],"receptor":[260],"19841was":[262],"major":[264],"breakthrough.":[265],"However,":[266],"proved":[268],"frustratingly":[269],"difficult":[270],"make":[272],"subsequent":[273],"progress":[274],"elucidation":[277],"molecular":[280],"transport.":[284],"An":[285],"understanding":[286],"\u2026":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}