{"id":"https://openalex.org/W239159095","doi":null,"title":"In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures.","display_name":"In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W239159095","mag":"239159095","pmid":"https://pubmed.ncbi.nlm.nih.gov/25826489"},"language":"en","primary_location":{"id":"pmid:25826489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25826489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061092436","display_name":"Hussam Abuelba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I304011483","display_name":"Grigore T. Popa University of Medicine and Pharmacy","ror":"https://ror.org/03hd30t45","country_code":"RO","type":"education","lineage":["https://openalex.org/I304011483"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Hussam Abuelba","raw_affiliation_strings":["Department of Cell and Molecular Biology, \"Grigore T. Popa\" University of Medicine and Pharmacy, Iassy, Romania; cotrutz@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, \"Grigore T. Popa\" University of Medicine and Pharmacy, Iassy, Romania; cotrutz@yahoo.com","institution_ids":["https://openalex.org/I304011483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067048363","display_name":"C Cotrutz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Elena Cotrutz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bogdan Alexandru Stoica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bogdan Alexandru Stoica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075992683","display_name":"Laura Stoica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Stoica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089025917","display_name":"Doini\u021ba Temelie-Olinici","orcid":"https://orcid.org/0000-0002-8622-5125","observed_orcids":["https://orcid.org/0000-0002-8622-5125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doini\u0162a Olinici","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042687873","display_name":"Tudor Petreu\u015f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tudor Petreu\u015f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8256,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.61133201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"56","issue":"1","first_page":"71","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/breast-adenocarcinoma","display_name":"breast adenocarcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9150000214576721},{"id":"https://openalex.org/keywords/monolayer-culture","display_name":"monolayer culture","score":0.8659999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anticancer-drug-evaluation","display_name":"anticancer drug evaluation","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9487917423248291},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7402664422988892},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.569815456867218},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.547386109828949},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5391552448272705},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.519601047039032},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5075732469558716},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4936569631099701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47657179832458496},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47050875425338745},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.4655604660511017},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4281325340270996},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35327303409576416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30447855591773987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20241841673851013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25826489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25826489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},{"id":"mag:239159095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25826489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4293216283","https://openalex.org/W7171632070","https://openalex.org/W1915087114","https://openalex.org/W2016823076","https://openalex.org/W7203492605","https://openalex.org/W2620126727","https://openalex.org/W4220719613","https://openalex.org/W2809324976","https://openalex.org/W2081372423","https://openalex.org/W2402712074"],"abstract_inverted_index":{"UNLABELLED:":[0],"Breast":[1,108],"adenocarcinoma":[2,109],"cell":[3,33,97,110,139,148,152,195,216,233,251],"line":[4,111,196],"MDA-MB-231,":[5],"even":[6],"if":[7],"it":[8,30],"expresses":[9],"low":[10,65,101],"levels":[11],"of":[12,19,64,159,165,181,200],"E-cadherin,":[13],"still":[14],"readily":[15],"form":[16],"multicellular":[17],"aggregates":[18],"cells,":[20],"namely":[21],"spheroids.":[22],"Curcumin":[23,50,205],"is":[24,224],"a":[25,79,163,179],"diarylheptanoid":[26],"antitumoral":[27],"drug":[28,248],"while":[29],"significantly":[31],"inhibits":[32,151],"migration,":[34],"invasion,":[35],"and":[36,41,45,75,119,127,155,188,202,213,219],"colony":[37],"formation":[38],"in":[39,48,130,210,227,243],"vitro":[40,244],"reduces":[42],"tumor":[43,96,153,194,215,232],"growth":[44],"liver":[46],"metastasis":[47],"vivo.":[49],"photoactivation":[51,187,206],"may":[52],"enhance":[53],"antiapoptotic":[54],"role":[55],"against":[56],"cancer":[57,193],"cells.":[58,145],"AIM:":[59],"To":[60],"evaluate":[61,89,138],"the":[62,90,239],"effect":[63],"curcumin":[66,129,142,150,223],"concentrations,":[67],"ranged":[68],"from":[69],"1.9":[70],"to":[71,88,93,116,125,137,176,222,237],"15":[72,160,182],"\u03bcM,":[73,161],"with":[74,162],"without":[76],"photoactivation,":[77],"using":[78],"manufactured":[80],"670":[81],"nm":[82],"LED-matrix.":[83],"A":[84,172],"secondary":[85],"aim":[86],"was":[87,135,184],"ideal":[91,240],"method":[92],"produce":[94],"easy-to-use":[95],"spheroids,":[98],"comparing":[99],"two":[100],"adherence":[102],"plate":[103],"supports.":[104],"MATERIALS":[105],"AND":[106],"METHODS:":[107],"MDA-MB-231":[112],"were":[113],"cultured":[114],"according":[115],"2D":[117,147,212],"monolayer":[118],"3D":[120,214,231],"spheroid":[121],"models":[122,218],"then":[123],"submitted":[124],"normal":[126],"photoactivated":[128],"micromolar":[131],"concentrations.":[132],"MTT":[133],"assay":[134],"used":[136],"viability":[140,164,174],"following":[141,186],"application":[143],"on":[144,191,250],"On":[146],"cultures,":[149],"development":[154],"proliferation":[156],"at":[157,167,198],"concentrations":[158,199],"65.7%":[166],"48":[168],"hours":[169],"incubation":[170],"time.":[171],"decreased":[173],"up":[175],"25%":[177],"for":[178,242],"concentration":[180],"\u03bcM":[183],"recorded":[185],"cytotoxic":[189],"action":[190],"breast":[192],"continued":[197],"7.5":[201],"3.75":[203],"\u03bcM.":[204],"increases":[207],"pro-apoptotic":[208],"effects":[209,249],"both":[211],"culture":[217,234],"also":[220],"responsiveness":[221],"slightly":[225],"reduced":[226],"spheroid-like":[228],"structures.":[229],"Thus,":[230],"systems":[235],"appear":[236],"be":[238],"environment":[241],"assays":[245],"regarding":[246],"anticancer":[247],"viability.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}