{"id":"https://openalex.org/W2391471878","doi":null,"title":"[Application of continuous blood purification combined with hemoperfusion in the treatment of hemolytic-uremic syndrome in children].","display_name":"[Application of continuous blood purification combined with hemoperfusion in the treatment of hemolytic-uremic syndrome in children].","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2391471878","mag":"2391471878","pmid":"https://pubmed.ncbi.nlm.nih.gov/23336170"},"language":"zh","primary_location":{"id":"pmid:23336170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23336170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103209303","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-4422-516X","observed_orcids":["https://orcid.org/0000-0002-4422-516X"]},"institutions":[{"id":"https://openalex.org/I4210147601","display_name":"Anhui Provincial Children's Hospital","ror":"https://ror.org/04je70584","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147601"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Department of Nephrology, Anhui Provincial Children's Hospital, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Anhui Provincial Children's Hospital, Hefei, China","institution_ids":["https://openalex.org/I4210147601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103666821","display_name":"Yang Dong","orcid":"https://orcid.org/0000-0001-7687-1775","observed_orcids":["https://orcid.org/0000-0001-7687-1775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102215042","display_name":"Daliang Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Da-Liang Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049900292","display_name":"Jiayun Jiang","orcid":"https://orcid.org/0000-0002-0802-5750","observed_orcids":["https://orcid.org/0000-0002-0802-5750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-Yun Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1308,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46192385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"1","first_page":"53","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-uremic-syndrome","display_name":"hemolytic uremic syndrome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/continuous-blood-purification","display_name":"continuous blood purification","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hemoperfusion","display_name":"hemoperfusion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8040000200271606},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.8059999942779541},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.6380000114440918},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2781123077","wikidata":"https://www.wikidata.org/wiki/Q3144950","display_name":"Hemoperfusion","level":3,"score":0.9118856191635132},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.7961527705192566},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7269797921180725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6636974811553955},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.6363998651504517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5312808752059937},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.46709033846855164},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4532157778739929},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.43130767345428467},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4031507670879364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3738399147987366},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.36927908658981323},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32479190826416016}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006440","descriptor_name":"Hemofiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006464","descriptor_name":"Hemoperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23336170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23336170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics","raw_type":"English Abstract"},{"id":"mag:2391471878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23336170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2352453512","https://openalex.org/W2367346857","https://openalex.org/W2367210001","https://openalex.org/W2356800060","https://openalex.org/W2373564354","https://openalex.org/W3029349162","https://openalex.org/W2023123052","https://openalex.org/W4200302014","https://openalex.org/W3031839521","https://openalex.org/W2383997178"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,38,45],"therapeutic":[4],"effect":[5],"of":[6,40,54,70,139,176],"continuous":[7],"blood":[8,71],"purification":[9],"(CBP)":[10],"combined":[11,34,121,154],"with":[12,17,30,35,115,122,155],"hemoperfusion":[13],"(HP)":[14],"in":[15,44,182],"children":[16,29,103,114],"hemolytic-uremic":[18],"syndrome":[19],"(HUS)":[20],"and":[21,49,58,68,95,124,132,135,147,166,168,173],"to":[22],"investigate":[23],"its":[24],"possible":[25],"mechanism.":[26],"METHODS:":[27],"Eight":[28,101],"HUS":[31,116,181],"received":[32],"CBP":[33,120,153],"HP":[36,123,156],"on":[37],"basis":[39],"internal":[41],"medicine":[42],"treatment":[43,150],"acute":[46],"stage.":[47],"Before":[48],"after":[50,119,149],"treatment,":[51],"serum":[52,75,137],"levels":[53,69,134,138],"interleukin-6":[55],"(IL-6),":[56],"IL-8":[57],"tumor":[59],"necrosis":[60],"factor-\u03b1":[61],"(TNF-\u03b1)":[62],"were":[63,99,107],"measured":[64],"by":[65],"chemiluminescence":[66],"method,":[67],"urea":[72],"nitrogen":[73],"(BUN),":[74],"creatinine":[76],"(SCr),":[77],"alanine":[78],"aminotransferase":[79,82],"(ALT),":[80],"aspartate":[81],"(AST),":[83],"creatine":[84,87],"kinase":[85,88],"(CK),":[86],"MB":[89],"(CKMB),":[90],"hemoglobin":[91],"(Hb),":[92],"platelet":[93],"(PLT)":[94],"C-reactive":[96],"protein":[97],"(CRP)":[98],"measured.":[100],"healthy":[102],"undergoing":[104],"physical":[105],"examination":[106],"used":[108],"as":[109],"controls.":[110],"RESULTS:":[111],"The":[112],"8":[113],"all":[117],"survived":[118],"showed":[125],"improved":[126],"conditions.":[127],"They":[128],"had":[129],"increased":[130],"Hb":[131],"PLT":[133],"decreased":[136],"IL-6,":[140],"IL-8,":[141],"TNF-\u03b1,":[142],"BUN,":[143],"SCr,":[144],"ALT,":[145],"CK":[146],"CRP":[148],"(P<0.05).":[151],"CONCLUSIONS:":[152],"can":[157],"quickly":[158],"remove":[159],"pathogenic":[160],"factors,":[161],"continually":[162],"eliminate":[163],"inflammatory":[164],"mediators":[165],"toxins,":[167],"reverse":[169],"multiple":[170],"organ":[171],"dysfunction,":[172],"is":[174],"one":[175],"effective":[177],"methods":[178],"for":[179],"treating":[180],"children.":[183]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}