{"id":"https://openalex.org/W2391443468","doi":null,"title":"Expressions of PTEN and MMP-2 in breast cancer and their clinical significance","display_name":"Expressions of PTEN and MMP-2 in breast cancer and their clinical significance","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2391443468","mag":"2391443468"},"language":"en","primary_location":{"id":"mag:2391443468","doi":null,"is_oa":true,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-NTYX200704016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-NTYX200704016.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056796466","display_name":"Yan Ping Guo","orcid":"https://orcid.org/0000-0001-5252-3960","observed_orcids":["https://orcid.org/0000-0001-5252-3960"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yan Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5252-3960","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056796466"],"corresponding_institution_ids":[],"apc_list":{"value":50,"currency":"USD","value_usd":50},"apc_paid":{"value":50,"currency":"USD","value_usd":50},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31674092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.07689999788999557,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.935529887676239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7428622245788574},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7311670780181885},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5740963220596313},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5023229122161865},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.49344077706336975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.488176167011261},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46988609433174133},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.4635773003101349},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.444749653339386},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4325956404209137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4132216274738312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1538471281528473},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08495792746543884},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.07496467232704163},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.06663587689399719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2391443468","doi":null,"is_oa":true,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-NTYX200704016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","raw_type":null}],"best_oa_location":{"id":"mag:2391443468","doi":null,"is_oa":true,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-NTYX200704016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1163365366","https://openalex.org/W2242763204","https://openalex.org/W2352712321","https://openalex.org/W1448348051","https://openalex.org/W969528736","https://openalex.org/W2376916319","https://openalex.org/W2354863463","https://openalex.org/W751345152","https://openalex.org/W2362586716","https://openalex.org/W991941948"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"the":[3,19,25,54,107,118,131,157,203],"expressions":[4,30,108,158],"of":[5,21,31,44,51,64,77,83,92,101,109,120,125,133,139,159,166,185,207],"PTEN":[6,32,65,84,102,140],"and":[7,15,24,37,66,71,111,113,146,152,161,163,182,205],"matrix":[8],"metalloproteinases":[9],"2":[10],"(MMP-2)":[11],"in":[12,41,74,87,149,189,202],"breast":[13,52,78,96,150,190,208],"cancer":[14,97],"their":[16],"relationship":[17],"with":[18,106,117,143,199],"expression":[20,68,81,100,119,124,132,138,165],"ER,":[22,35],"PR,":[23,162],"clinicopathological":[26],"features.":[27],"Methods:":[28],"The":[29,61,80,99,123,168],",":[33],"MMP-2,":[34],"PR":[36],"c-erbB-2":[38,121,134,200],"were":[39,69,85],"detected":[40],"68":[42,75],"cases":[43,76],"invasive":[45],"ductal":[46],"carcinoma(not":[47],"otherwise":[48],"specified,":[49],"NOS)":[50],"using":[53],"standard":[55],"streptavidin":[56],"peroxidase":[57],"(SP)":[58],"method.":[59],"Results:":[60],"positive":[62],"rates":[63],"MMP-2":[67,126,169],"42.6%":[70],"54.4%":[72],"respectively,":[73],"cancer.":[79,209],"levels":[82],"higher":[86,147],"well-differentiated":[88],"(\u2160-\u2161degree)and":[89],"earlier-stage":[90],"(\u2160-\u2161stage":[91],"TNM":[93],"staging":[94],"system)":[95],"(P0.01).":[98,122,135],"was":[103,114,127,141,153],"correlated":[104,115,142],"positively":[105,129],"ER":[110,160],"PR(P0.01),":[112],"negatively":[116],"related":[128],"to":[130,195],"Conclusion:The":[136],"loss":[137],"poor":[144],"differentiation":[145],"aggressiveness":[148],"cancer,":[151,191],"accompanied":[154],"by":[155],"reduced":[156],"increased":[164],"c-erbB-2.":[167],"protein":[170],"plays":[171],"an":[172],"independent":[173],"role":[174],"among":[175],"different":[176,179,183],"histologic":[177],"grades,":[178],"clinical":[180],"stages":[181],"status":[184],"steroid":[186],"hormone":[187],"receptors":[188],"but":[192],"is":[193],"likely":[194],"have":[196],"synergistic":[197],"effect":[198],"oncogene":[201],"genesis":[204],"progression":[206]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}