{"id":"https://openalex.org/W2391410089","doi":null,"title":"Keratinocyte growth factor treatment prevents radiation-induced intestinal damage in a mouse model","display_name":"Keratinocyte growth factor treatment prevents radiation-induced intestinal damage in a mouse model","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2391410089","mag":"2391410089"},"language":"en","primary_location":{"id":"mag:2391410089","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLYD201313060.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua linchuang yishi zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103869860","display_name":"Li Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Ji","raw_affiliation_strings":["Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking Union Medical College","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103869860"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31118368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/radiation-induced-intestinal-injury","display_name":"radiation enteritis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.5249999761581421},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/137cs-gamma-rays","display_name":"137Cs gamma rays","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/intestinal-pathology","display_name":"intestinal pathology","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.8975480794906616},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.6095479726791382},{"id":"https://openalex.org/C2993278735","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Radiation injury","level":3,"score":0.5613916516304016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45525890588760376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.447727233171463},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.42655718326568604},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4038046896457672},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36353591084480286},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36203235387802124},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35378068685531616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32255393266677856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3202885389328003},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3068464398384094},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08050671219825745}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2391410089","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLYD201313060.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua linchuang yishi zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029792161","https://openalex.org/W2087570664","https://openalex.org/W1493614585","https://openalex.org/W2743499939","https://openalex.org/W7100925534","https://openalex.org/W2040510980","https://openalex.org/W3032315811","https://openalex.org/W7096432762","https://openalex.org/W2131707390","https://openalex.org/W2018038878"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2],"protective":[3],"effect":[4],"of":[5,34,54,85],"keratinocyte":[6],"growth":[7],"factor(KGF)":[8],"in":[9,13,68,80,124],"radiation-induced":[10,121],"intestinal":[11,122],"injury":[12,123],"a":[14,46,125],"mouse":[15,126],"model.Methods":[16],"The":[17],"C57BL":[18],"/6J":[19],"mice":[20],"were":[21,41,44,61,66],"randomly":[22],"divided":[23],"into":[24],"five":[25],"groups:":[26],"control":[27,39],"group,radiation":[28],"group":[29,40,99],"and":[30,64,83],"low,middle,high":[31],"dose":[32,53,88,98,108],"groups":[33,43,76,89,109],"KGF(1,2,4":[35],"mg":[36],"/":[37],"kg).The":[38],"shamirradiated,other":[42],"given":[45],"single":[47],"whole":[48],"body":[49,59,81],"irradiation":[50],"at":[51],"the":[52],"7.2":[55],"Gy":[56],"with137CS-\u03b3":[57],"rays.Then":[58],"weight":[60,82],"measured,protein,NO":[62],"concentrations":[63,92,102,112],"pathology":[65,84],"observed":[67],"intestinal.Results":[69],"Compared":[70],"with":[71,90,100,110],"simple":[72],"IR":[73],"group,KGF":[74],"treatment":[75,118],"showed":[77],"better":[78],"status":[79],"intestinal,KGF":[86],"low,middle":[87],"protein":[91,101],"had":[93,103,113],"statistically":[94,104,114],"significant(P":[95,105,115],"0.05),KGF":[96],"high":[97],"0.01),KGF":[106],"middle,high":[107],"NO":[111],"0.05).Conclusion":[116],"KGF":[117],"could":[119],"improve":[120],"model.":[127]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}