{"id":"https://openalex.org/W2391387698","doi":null,"title":"[Preparation of nosiheptide liposomes and its inhibitory effect on hepatitics B virus in vitro].","display_name":"[Preparation of nosiheptide liposomes and its inhibitory effect on hepatitics B virus in vitro].","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2391387698","mag":"2391387698","pmid":"https://pubmed.ncbi.nlm.nih.gov/16220794"},"language":"zh","primary_location":{"id":"pmid:16220794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033383790","display_name":"Qin-sheng Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-sheng Cai","raw_affiliation_strings":["School of Pharmacy, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027184005","display_name":"Hai Yan Huang","orcid":"https://orcid.org/0000-0002-6928-3198","observed_orcids":["https://orcid.org/0000-0002-6928-3198","https://orcid.org/0000-0001-9841-1147","https://orcid.org/0009-0006-9877-2755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082856820","display_name":"Meiqing Feng","orcid":"https://orcid.org/0000-0003-0106-0737","observed_orcids":["https://orcid.org/0000-0003-0106-0737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei-qing Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052628735","display_name":"Pei Zhou","orcid":"https://orcid.org/0000-0003-2006-9163","observed_orcids":["https://orcid.org/0000-0003-2006-9163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2389,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.67235677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"40","issue":"5","first_page":"462","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.20999999344348907,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0934000015258789,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nosiheptide","display_name":"nosiheptide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hbsag-secretion","display_name":"HBsAg secretion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hbeag-secretion","display_name":"HBeAg secretion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liposome-preparation","display_name":"liposome preparation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/sonication","display_name":"sonication","score":0.8169999718666077},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8169999718666077},{"id":"https://openalex.org/keywords/liposome-stability","display_name":"liposome stability","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.9467918872833252},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.8472409248352051},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.7596477270126343},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.705602765083313},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.57390296459198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.515898585319519},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43472588062286377},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42338842153549194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3063719868659973},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30049097537994385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2784838080406189}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006513","descriptor_name":"Hepatitis B e Antigens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16220794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"English Abstract"},{"id":"mag:2391387698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158949061","https://openalex.org/W2377050244","https://openalex.org/W2313268541","https://openalex.org/W2376623460","https://openalex.org/W2035534644","https://openalex.org/W3014497059","https://openalex.org/W2466455480","https://openalex.org/W2386311473","https://openalex.org/W2350339811","https://openalex.org/W2073604015"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"prepare":[2],"liposomes":[3,86,111,123,128,142],"of":[4,21,57,85,100,103,110,116,118,141,187],"nosiheptide":[5,22],"and":[6,16,29,36,67,161,196,206],"study":[7],"its":[8],"ability":[9,199],"to":[10,53,61,200],"inhibit":[11,62,144,201],"hepatitis":[12,63,202],"B":[13,64,203],"virus":[14,65,204],"HBsAg":[15,66,145,205],"HBeAg":[17,68,162,207],"secreted.":[18],"METHODS:":[19],"Liposomes":[20,186],"was":[23,32,39,51,70,91],"prepared":[24,191],"by":[25,34,41,72,87,95,147,164,192],"sodium":[26,119,193],"deoxycholate":[27,194],"dialysis":[28,195],"sonication.":[30],"Nosheptide":[31],"determined":[33,40],"HPLC":[35],"partical":[37,124],"size":[38,125],"using":[42],"laser":[43],"light":[44],"scattering":[45],"instrument.":[46],"Transmission":[47],"electron":[48],"microscopy":[49],"(TEM)":[50],"used":[52],"examine":[54],"the":[55,98,101,107,114,122],"morphology":[56],"liposomes.":[58],"Its":[59],"actions":[60],"secreted":[69,146,163,208],"studied":[71],"a":[73],"HBV-transfectted":[74],"cell":[75],"line":[76],"(HepG2":[77],"2.":[78,79,150],"15":[80],").":[81],"RESULTS:":[82],"Encapsulation":[83],"efficiency":[84,109],"chloroform:methanol":[88],"(2:1,":[89],"v/v)":[90],"higher":[92],"than":[93,211],"that":[94,143],"dioxane.":[96],"With":[97],"increase":[99,115],"ratio":[102,117],"nosiheptide:":[104],"PC":[105],"(W/W),":[106],"encapsulation":[108],"decreased":[112],"with":[113],"deoxycholate:":[120],"PC,":[121],"decreased.":[126],"The":[127,138],"kept":[129],"stable":[130],"at":[131],"-20":[132],"degrees":[133],"C":[134],"after":[135],"2":[136],"years.":[137],"drug":[139],"concentrations":[140],"(46.9":[148],"+/-":[149,154,158,166,170,174],"6)":[151],"%,":[152,156,168,172],"(55.4":[153],"1.2)":[155],"(65":[157],"3)":[159],"%":[160,176],"(15.1":[165],"2.3)":[167],"(36.2":[169],"1.7)":[171],"(36.8":[173],"2.5)":[175],"were":[177],"1.25,":[178],"2.5,":[179],"5.0":[180],"microg":[181],"x":[182],"mL(-1),":[183],"respectively.":[184],"CONCLUSION:":[185],"nosheptide":[188],"can":[189],"be":[190],"sonication,":[197],"which":[198],"is":[209],"better":[210],"nosheptide.":[212]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
