{"id":"https://openalex.org/W2391281983","doi":"https://doi.org/10.3760/cma.j.issn.1007-8118.2002.05.013","title":"Large-scale cultivation of porcine hepatocyte spheroids","display_name":"Large-scale cultivation of porcine hepatocyte spheroids","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2391281983","doi":"https://doi.org/10.3760/cma.j.issn.1007-8118.2002.05.013","mag":"2391281983"},"language":"en","primary_location":{"id":"mag:2391281983","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGD200205018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764921924","display_name":"Zhonghua gan-dan waike zazhi","issn_l":"1007-8118","issn":["1007-8118"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua gan-dan waike zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006314269","display_name":"Wei Zhu","orcid":"https://orcid.org/0000-0001-5032-6277","observed_orcids":["https://orcid.org/0000-0001-5032-6277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6731\u8587","raw_affiliation_strings":["510515,\u5e7f\u5dde\u5e02,\u7b2c\u4e00\u519b\u533b\u5927\u5b66\u5357\u65b9\u533b\u9662\u5168\u519b\u6d88\u5316\u75c5\u7814\u7a76\u6240","YUAN Aili  LAI Zhuosheng, et al"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"510515,\u5e7f\u5dde\u5e02,\u7b2c\u4e00\u519b\u533b\u5927\u5b66\u5357\u65b9\u533b\u9662\u5168\u519b\u6d88\u5316\u75c5\u7814\u7a76\u6240","institution_ids":[]},{"raw_affiliation_string":"YUAN Aili  LAI Zhuosheng, et al","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023831057","display_name":"Pla Digestion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"\u8881\u7231\u529b","raw_affiliation_strings":["Institute, Nanfang Hospital, First Military Medical University,Guangzhou 510515,P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute, Nanfang Hospital, First Military Medical University,Guangzhou 510515,P","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"\u8d56\u5353\u80dc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8d56\u5353\u80dc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Chen","orcid":"https://orcid.org/0000-0001-8937-3804","observed_orcids":["https://orcid.org/0000-0001-8937-3804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8937-3804","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u738b\u4e9a\u4e1c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u738b\u4e9a\u4e1c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"\u5218\u601d\u5fb7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u601d\u5fb7","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37403324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"301","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-hepatocytes","display_name":"porcine hepatocytes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hepatocyte-spheroids","display_name":"hepatocyte spheroids","score":0.9929999709129333},{"id":"https://openalex.org/keywords/large-scale-cell-culture","display_name":"large-scale cell culture","score":0.7720000147819519},{"id":"https://openalex.org/keywords/liver-parenchyma","display_name":"liver parenchyma","score":0.7139999866485596},{"id":"https://openalex.org/keywords/nonparenchymal-liver-cells","display_name":"non-parenchymal liver cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/albumin-secretion","display_name":"albumin secretion","score":0.972000002861023},{"id":"https://openalex.org/keywords/ammonium-removal","display_name":"ammonium removal","score":0.902999997138977},{"id":"https://openalex.org/keywords/bioartificial-liver","display_name":"bioartificial liver","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.9754955768585205},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.9252655506134033},{"id":"https://openalex.org/C71867830","wikidata":"https://www.wikidata.org/wiki/Q17103308","display_name":"Bioartificial liver device","level":4,"score":0.6502134799957275},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.6416298151016235},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5275231003761292},{"id":"https://openalex.org/C2994599478","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver parenchyma","level":2,"score":0.5105858445167542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4102891683578491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3738405704498291},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26995742321014404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20722493529319763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1363356113433838},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11918392777442932},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.055788278579711914}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2391281983","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGD200205018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764921924","display_name":"Zhonghua gan-dan waike zazhi","issn_l":"1007-8118","issn":["1007-8118"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua gan-dan waike zazhi","raw_type":null},{"id":"mag:3028799425","doi":"https://doi.org/10.3760/cma.j.issn.1007-8118.2002.05.013","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN113884200205/780879.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764921924","display_name":"Zhonghua gan-dan waike zazhi","issn_l":"1007-8118","issn":["1007-8118"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u809d\u80c6\u5916\u79d1\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419793573","https://openalex.org/W2044437100","https://openalex.org/W2370517129","https://openalex.org/W2199678495","https://openalex.org/W2409840566","https://openalex.org/W3152274949","https://openalex.org/W2047239081","https://openalex.org/W2367514210","https://openalex.org/W2415744850","https://openalex.org/W2076224708"],"abstract_inverted_index":{"Objective":[0],"To":[1],"establish":[2],"a":[3,53],"method":[4,75],"of":[5,76,85],"cultivation":[6],"large":[7,78],"scale":[8,79],"liver":[9,80,96],"parenchyma":[10,81],"and":[11,14,43,63,82],"noparenchyma":[12,83],"cells":[13,84],"to":[15],"form":[16],"the":[17,45,65],"porcine":[18],"hepatocyte":[19,39,50,86],"spheroids.":[20],"Methods":[21],"We":[22,32],"performed":[23],"spheroid":[24],"in":[25,49,52],"1":[26],"L":[27],"magnetic":[28],"culture":[29],"vessels.":[30],"Results":[31],"obtained":[33],"approximately":[34],"2\u00d710":[35],"10":[36,38],"\uff5e5\u00d710":[37],"spheroids":[40,51,87],"one":[41,92],"time":[42,93],"observe":[44],"hepatic":[46],"special":[47],"structure":[48],"electric":[54],"microscope.":[55],"They":[56],"expressed":[57],"three":[58],"times":[59],"more":[60],"albumin":[61],"secretion":[62],"twice":[64],"ammonium":[66],"removal":[67],"as":[68],"compared":[69],"with":[70],"conventional":[71],"monolayers.":[72],"Conclusions":[73],"The":[74],"cultivating":[77],"can":[88],"provide":[89],"enough":[90],"hepatocyts":[91],"for":[94],"bioartificial":[95],"support":[97],"systems.":[98]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
